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pro vyhledávání: '"Ellen F. Barrett"'
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 3, Pp 399-408 (2012)
Muscle endplates become denervated in mice that express mutations of human superoxide dismutase 1 (hSOD1), models of familial amyotrophic lateral sclerosis. This denervation is especially marked in fast limb muscles, and precedes death of motor neuro
Externí odkaz:
https://doaj.org/article/b6b1694b9e9a4ed4bb7d05a9f63f972b
Publikováno v:
Neurobiology of Disease, Vol 42, Iss 3, Pp 381-390 (2011)
Mitochondria in motor nerve terminals temporarily sequester large Ca2+ loads during repetitive stimulation. In wild-type mice this Ca2+ uptake produces a small (
Externí odkaz:
https://doaj.org/article/cb86273cc2e443b19f8c1327002f305c
Publikováno v:
Journal of Neurophysiology. 129:700-716
Pulses of infrared light (IR) provide a novel method for rapidly transferring Ca2+ from the endoplasmic reticulum to mitochondria in intact cells. In PC12 cells the resulting ETC activation was not driven by increased ATP synthase activity or NADH. I
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2014)
Abundant evidence indicates that mitochondrial dysfunction and Ca2+ dysregulation contribute to the muscle denervation and motor neuron death that occur in mouse models of familial amyotrophic lateral sclerosis (fALS). This perspective considers meas
Externí odkaz:
https://doaj.org/article/2198e618d5704c0c860b29a7422889b1
Autor:
John N. Barrett, Cristina Matthewman, Samantha Rincon, Ellen F. Barrett, Suhrud M. Rajguru, Julio Pasos, Jayanti Singh
Publikováno v:
Journal of Neurophysiology. 120:509-524
Inner ear spiral ganglion neurons were cultured from day 4 postnatal mice and loaded with a fluorescent Ca2+indicator (fluo-4, -5F, or -5N). Pulses of infrared radiation (IR; 1,863 nm, 200 µs, 200–250 Hz for 2–5 s, delivered via an optical fiber
Autor:
Osama Saleh, Carlos T. Moraes, Ellen F. Barrett, Doris Nonner, John N. Barrett, Michael G. White
Publikováno v:
Journal of Neurophysiology. 108:2203-2214
Previous work demonstrated that hyperthermia (43°C for 2 h) results in delayed, apoptotic-like death in striatal neuronal cultures. We investigated early changes in mitochondrial function induced by this heat stress. Partial depolarization of the mi
Autor:
Ellen F. Barrett, Janet D. Talbot, John N. Barrett, Kyle Wicomb, Doris Nonner, Zhongsheng Zhang
Publikováno v:
Experimental neurology. 285
In mutant superoxide dismutase 1 (SOD1) mouse models of familial amyotrophic lateral sclerosis (fALS) some of the earliest signs of morphological and functional damage occur in the motor nerve terminals that innervate fast limb muscles. This study te
Publikováno v:
Experimental Neurology. 234:95-104
Motor nerve terminals are especially sensitive to an ischemia/reperfusion stress. We applied an in vitro model of this stress, oxygen/glucose deprivation (OGD), to mouse neuromuscular preparations to investigate how Ca(2+) contributes to stress-induc
Publikováno v:
Neurobiology of Disease, Vol 42, Iss 3, Pp 381-390 (2011)
Mitochondria in motor nerve terminals temporarily sequester large Ca(2+) loads during repetitive stimulation. In wild-type mice this Ca(2+) uptake produces a small (
Publikováno v:
Neuron. 68(6):1097-1108
Key components of vesicular neurotransmitter release, such as Ca(2+) influx and membrane recycling, are affected by cytosolic pH. We measured the pH-sensitive fluorescence of Yellow Fluorescent Protein transgenically expressed in mouse motor nerve te