Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ellen E. Connor"'
Publikováno v:
The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society. 168(3)
A 51-year-old man presented to a community based emergency department with bilateral lower extremity swelling that began four days prior and that had evolved into recent blister formation on the left lower extremity. Medical history was significant o
Publikováno v:
The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society. 166(6)
Emergency medical responders were activated to the home of a 59-year-old African-American male in distress and with known Down syndrome complicated by Alzheimer’s disease. He was found to be unresponsive and subsequently became pulseless. Advanced
Autor:
Mark A. Berg, Robert S. Coleman, Michael D. Wyatt, Latha A. Gearheart, Ellen E. Connor, Ala Issa, David M. Wilson, Nicole A. Paraggio, Sobhan Sen
Publikováno v:
Biophysical Journal. 89:4129-4138
Synthetic oligonucleotides with a fluorescent coumarin group replacing a basepair have been used in recent time-resolved Stokes-shift experiments to measure DNA dynamics on the femtosecond to nanosecond timescales. Here, we show that the APE1 endonuc
Publikováno v:
Biochemical Pharmacology. 70:1458-1468
Thymidylate synthase (TS) is an important target of several chemotherapeutic agents. During TS inhibition, dTTP levels decrease with a subsequent increase in dUTP. Uracil incorporated into the genome is removed by base excision repair (BER). BER has
Publikováno v:
Chemical research in toxicology. 18(1)
The human 3-methyladenine (AAG, ANPG, MPG) DNA glycosylase excises alkylated purines from DNA. In previous studies, we determined the importance of an active site amino acid (asparagine 169) in the recognition of substrates by AAG. In this study, we
Autor:
Weiguo Cao, Liang Dong, Thomas M. Hitchcock, Lisiane B. Meira, Ellen E. Connor, Michael D. Wyatt, Leona D. Samson
Publikováno v:
The Journal of biological chemistry. 279(37)
Oxanine (Oxa) is a deaminated base lesion derived from guanine in which the N(1)-nitrogen is substituted by oxygen. This work reports the mutagenicity of oxanine as well as oxanine DNA glycosylase (ODG) activities in mammalian systems. Using human DN
Active-Site Clashes Prevent the Human 3-Methyladenine DNA Glycosylase from Improperly Removing Bases
Autor:
Ellen E. Connor, Michael D. Wyatt
Publikováno v:
Chemistry & Biology. (9):1033-1041
The human 3-methyladenine DNA glycosylase (AAG, MPG) removes a diverse array of damaged purines via a nucleotide-flipping mechanism. In the crystal structure of AAG bound to DNA containing 1,N6 ethenoadenine, an asparagine (N169) occupies the active-
Autor:
Ponce MB; University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Schauberger E; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Connor E; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Reeder M; Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Publikováno v:
Contact dermatitis [Contact Dermatitis] 2024 Oct; Vol. 91 (4), pp. 364-365. Date of Electronic Publication: 2024 Jun 24.
Autor:
Davies P; Department of Obstetrics and Gynecology, Queens University, Kingston, Ontario, Canada., Connor E; Department of Pediatric Endocrinology, University of Wisconsin, Madison, Wisconsin., MacKenzie J; Department of Medical Genetics, Queens University, Kingston, Ontario, Canada., Jamieson MA; Department of Obstetrics and Gynecology, Queens University, Kingston, Ontario, Canada. Electronic address: maj3@queensu.ca.
Publikováno v:
Journal of pediatric and adolescent gynecology [J Pediatr Adolesc Gynecol] 2015 Aug; Vol. 28 (4), pp. e101-3. Date of Electronic Publication: 2014 Sep 16.