Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Ellen E. Codd"'
Autor:
Junguo Zhou, Sandra De Jonghe, Ellen E. Codd, Sandy Weiner, David Gallacher, Paul Stahle, Michael F. Kelley, Edwin K. Kuffner, Christopher M. Flores, Gary E. Eichenbaum
Publikováno v:
Regulatory toxicology and pharmacology : RTP.
JNJ-10450232 (NTM-006) is a new molecular entity that is structurally related to acetaminophen. A comprehensive non-clinical safety program was conducted to support first-in-human and clinical efficacy studies based on preclinical data suggesting tha
Publikováno v:
Antimicrob Agents Chemother
Oxfendazole is a potent veterinary antiparasitic drug undergoing development for human use to treat multiple parasitic infections. Results from two recently completed phase I clinical trials conducted in healthy adults showed that the pharmacokinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93ff3e495f6dd4db366818562f0b115
https://europepmc.org/articles/PMC8765237/
https://europepmc.org/articles/PMC8765237/
Autor:
Robert H. Gilman, Gregory A. Deye, Ellen E. Codd, Jessie K. Kennedy, John R. Horton, Thanh Bach, Guohua An, Effie Y.H. Nomicos, Shirley Galbiati, Patricia L. Winokur, Armando E. Gonzalez, Hector H. Garcia
Publikováno v:
Antimicrob Agents Chemother
Neurocysticercosis and trichuriasis are difficult-to-treat parasitic infections that affect more than 1.5 billion people worldwide. Oxfendazole, a potent broad-spectrum benzimidazole anthelmintic approved for use in veterinary medicine, has shown sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2e6022857de1793d07ea5c2f73df0b
https://europepmc.org/articles/PMC7577123/
https://europepmc.org/articles/PMC7577123/
Autor:
Thomas Conrad, Thanh Bach, Jessie K. Kennedy, Armando E. Gonzalez, Larissa V. Stebounova, Hector H. Garcia, Kiran Gajurel, Daryl J. Murry, Greg Deye, Patricia L. Winokur, Walt Jones, Denice M. Hodgson-Zingman, John R. Horton, Ellen E. Codd, Effie Y.H. Nomicos, Guohua An, Robert H. Gilman, Dilek Ince
Cysticercosis is a parasitic disease that frequently involves the human central nervous system (CNS), and current treatment options are limited. Oxfendazole, a veterinary medicine belonging to the benzimidazole family of anthelmintic drugs, has demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f203b7c43ba03e0341087ee72baa34
https://hdl.handle.net/20.500.12866/7396
https://hdl.handle.net/20.500.12866/7396
Publikováno v:
Expert review of anti-infective therapy. 17(1)
INTRODUCTION. Oxfendazole (methyl [5-(phenylsulphinyl)-1H benzimidazole- 2-yl] carbamate) has a particularly long metabolic half-life in ruminants, and its metabolite fenbendazole also has anthelminthic action. A very limited number of drugs are avai
Autor:
Ling Lin, Chaozhong Cai, Christopher M. Flores, Timothy P Coogan, Edmund K. LeGrand, Ellen E. Codd, Raymond W. Colburn, Angelique Leone, Charles Y. Wang, Mcdonnell Mark E, Scott L. Dax, Michael R. Brandt, Stewart Bryant, Bart DeCorte, James J. McNally, John R. Mabus, Sui-Po Zhang, John R. Carson, Michael Kemmerer, Dennis J. Stone, James M Lenhard, Michael K. McMillian, Kristen M. Chevalier, Judith Baker
Publikováno v:
Toxicological Sciences. 117:493-504
The unexpected observation of a hyperglycemic effect of some tricycle-based delta opioid receptor (DOR) agonists led to a series of studies to better understand the finding. Single administration of two novel tricyclic DOR agonists dose dependently e
Publikováno v:
SLAS Discovery. 11:672-677
N-type calcium channels located on presynaptic nerve terminals regulate neurotransmitter release, including that from the spinal terminations of primary afferent nociceptors. Accordingly, N-type calcium channel blockers may have clinical utility as a
Autor:
John R. Carson, Lou Anne Neilson, Ellen E. Codd, Jung Lee, Philip M. Pitis, Rebecca P. Martinez, Scott L. Dax, L. A. McKown, Wu-Nan Wu, Steven J. Coats, Sui-Po Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2113-2116
The tertiary amide delta opioid agonist 2 is a potent antinociceptive agent. Compound 2 was metabolized in vitro and in vivo to secondary amide 3, a potent and selective micro opioid agonist. The SAR of a series of N-alkyl-4-[(8-azabicyclo[3.2.1]-oct
Autor:
Rebecca P. Martinez, John R. Carson, Lou Anne Neilson, Steven J. Coats, Ellen E. Codd, Sui-Po Zhang, Jung Lee, Philip M. Pitis, Scott L. Dax
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2109-2112
A series of N , N -dialkyl-4-(9-aryltropanylidenemethyl)benzamides was prepared. The lead compounds, 15a and 15c , exhibited extremely high affinity for the δ opioid receptor with excellent selectivity versus the μ opioid receptor. They were full a
Publikováno v:
European Journal of Biochemistry. 270:4762-4770
The voltage gated sodium channel comprises a pore-forming α subunit and regulatory β subunits. We report here the identification and characterization of a novel splicing variant of the human β1 subunit, termed β1B. The 807 bp open reading frame o