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NLRP3-dependent IL-1β production by FcγR-mediated Syk kinase signaling confers protective immunity in Francisella tularensis vaccination (VAC7P.966)

Autor: Sivakumar Periasamy, Ellen Duffy, Jonathan Harton

Publikováno v: The Journal of Immunology. 192:141.11-141.11

Pneumonic tularemia is a fatal disease caused by Francisella tularensis (Ft), a category ‘A’ biothreat agent with no FDA approved vaccine. Previous studies have shown that inactivated-Ft (iFt) complexed with anti-Ft LPS mAb (iFt-mAb) elicits prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61f9cd473f66cf936480a83509b08989
https://doi.org/10.4049/jimmunol.192.supp.141.11

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NLRP3 directs inflammasome activation in response to live F. tularensis infection (42.20)

Autor: Maninjay Atianand, Aaloki Shah, Ellen Duffy, Supriya Kar, Meenakshi Malik, Jonathan Harton

Publikováno v: The Journal of Immunology. 184:42.20-42.20

Detection of intracellular pathogens is facilitated by members of the nucleotide binding-leucine rich receptor (NLR) family. The role of ASC/Caspase-1 axis for protective innate immunity against Francisella infection is well established, however the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f008617a62fcd2a29c537c9ca20f993e
https://doi.org/10.4049/jimmunol.184.supp.42.20

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Allocytotoxic T cell clones: both Leu 2+3− and Leu 2−3+ T cells recognize class I histocompatibility antigens

Autor: Bo Dupont, Robert Evans, Ellen Duffy, Robert W. Knowles, Neal Flomenberg, Kazuyuki Naito

Publikováno v: European Journal of Immunology. 13:905-911

T cell clones were selected which were cytotoxic for human class I major histocompatibility target antigens. Specificity was based on target cell panel studies and inhibition by monoclonal antibodies to class I determinants. Eight clones were Leu 2+3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6f99439ad0424f7228fbc68b1bd803
https://doi.org/10.1002/eji.1830131109

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