Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ellen C. Spoelstra"'
Publikováno v:
European Journal of Biochemistry. 207:567-579
Drug permeation across the plasma membrane of multidrug-resistant cells depends on the kinetics of the P-glycoprotein-mediated pump activity as well as well as on the passive permeation of the drug. We here demonstrate a method to characterize kineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29115b566331afc7484e118c80cd62c9
https://doi.org/10.1111/j.1432-1033.1992.tb17083.x
https://doi.org/10.1111/j.1432-1033.1992.tb17083.x
Autor:
Gerrit Jan Schuurhuis, Ellen C. Spoelstra, Henricus J. Broxterman, Jan Lankelma, Henk L. Dekker
Publikováno v:
Biochemical Pharmacology. 41:349-359
We studied the resistance of colon tumors to anticancer agents in vitro. Using daunorubicin (DN), a number of cellular parameters which normally indicate acquired or multidrug resistance (MDR), were compared for several human wild-type colon cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::043ac66cf62987eb244bc5fbd644a866
https://doi.org/10.1016/0006-2952(91)90531-9
https://doi.org/10.1016/0006-2952(91)90531-9
Autor:
Hans V. Westerhoff, Jan Lankelma, Ellen C. Spoelstra, Martin Bier, Peter Richard, Douwe Molenaar, A. P. M. Jongsma, Peter Ruhdal Jensen, Boris N. Kholodenko
Publikováno v:
Biomedical and Life Physics ISBN: 9783322850195
The Control Theory of steady states in “ideal” cells is largely complete. We shall discuss some recent advances in the development of control theory for a more realistic cellular physiology, which includes channelling of metabolites, group relay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dd0611c4147f484da7c50d97f38db91
https://doi.org/10.1007/978-3-322-85017-1_3
https://doi.org/10.1007/978-3-322-85017-1_3
Publikováno v:
European Journal of Biochemistry, 221, 363-373. Wiley-Blackwell
We examined P-glycoprotein-mediated verapamil transport, using two drug-sensitive and multi-drug resistant cell-line couples, i.e. A2780, 2780AD and SW-1573, SW-1573/1R500. The interaction of 3H-labeled verapamil with cells was measured using a flow-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3359c22a95885b9f06a42aee67e32d
https://dare.uva.nl/personal/pure/en/publications/the-multidrug-resistance-reverser-verapamil-with-cellular-pglycoproteinmediated-pumping-of-daunorubicin-as-a-noncompeting-substrate(1500eee2-8036-4608-b783-c29ea87a45d5).html
https://dare.uva.nl/personal/pure/en/publications/the-multidrug-resistance-reverser-verapamil-with-cellular-pglycoproteinmediated-pumping-of-daunorubicin-as-a-noncompeting-substrate(1500eee2-8036-4608-b783-c29ea87a45d5).html
Publikováno v:
Spoelstra, E C, Pinedo, H M, Dekker, H, Peters, G J & Lankelma, J 1991, ' Measurement of in vitro cellular pharmacokinetics of 5-fluorouracil in human and rat cancer cell lines and rat hepatocytes using a flow-through system ', Cancer Chemotherapy and Pharmacology, vol. 27, pp. 320-325 .
Cancer Chemotherapy and Pharmacology, 27, 320-325. Springer Verlag
Cancer Chemotherapy and Pharmacology, 27, 320-325. Springer Verlag
A flow-through system was used to study the cellular pharmacokinetics of 5-fluorouracil (5-FU) in four human cell lines (squamous-cell carcinoma HEp-2, colon carcinoma WiDr, hepatoma Hep G2, and breast carcinoma MCF-7) as well as in the rat hepatoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e49175ccf46fa4b00e008c42c195560
https://pubmed.ncbi.nlm.nih.gov/1998989
https://pubmed.ncbi.nlm.nih.gov/1998989
Publikováno v:
Biochimica et biophysica acta. 1055(3)
Using a flow-through system human multidrug-resistant 2780 AD ovarian carcinoma cells were exposed to flowing culture medium containing the anticancer agent daunomycin (5 μM). A pulse of medium containing verapamil caused increased cellular daunomyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f8e989256621046d692e64dd8f0cf2
https://pubmed.ncbi.nlm.nih.gov/1979920
https://pubmed.ncbi.nlm.nih.gov/1979920
Autor:
Bastiaan R. Leeflang, Pieter de Waard, Johannes F.G. Vliegenthart, Johannis P. Kamerling, Jan B. Bouwstra, Ellen C. Spoelstra
Publikováno v:
European journal of biochemistry. 190(1)
1H- and 13C-NMR assignments for the carbohydrate part of the glycopeptide alpha-D-Man-(1----6)-[beta-D-Xyl-(1----2)]-beta-D-Man-(1----4)-beta-D- GlcNAc-(1----4)-[alpha-L-Fuc-(1----3)]-beta-D-GlcNAc-(1----N)-Asn approximately, derived from the proteol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30319001889577a7c8f14846af65c2ed
https://pubmed.ncbi.nlm.nih.gov/2364940
https://pubmed.ncbi.nlm.nih.gov/2364940
Autor:
R.J.M. Timmers, Arie J. Verkleij, R. van der Neut, Y.M. Huigen, Ellen C. Spoelstra, Klaas Nicolay, J.J. Fok, B. de Kruijff
Publikováno v:
Biochimica et Biophysica Acta (BBA)-Biomembranes, 778(2), 359. Elsevier
Biochimica et Biophysica Acta, Biomembranes, 778(2), 359-371. Elsevier
Biochimica et Biophysica Acta, Biomembranes, 778(2), 359-371. Elsevier
The interaction of adriamycin with cardiolipin in model membranes and in various membrane preparations derived from rat liver mitochondria was studied and the results are analyzed in the light of a possible specific interaction between adriamycin and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88cb65a5b243d3b0e1611c2b6e5340f1
https://doi.org/10.1016/0005-2736(84)90380-8
https://doi.org/10.1016/0005-2736(84)90380-8