Výsledky vyhledávání - "Ellen C. Moore"

Akademický článek

Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies

Autor: Jay Friedman, Megan Morisada, Lillian Sun, Ellen C. Moore, Michelle Padget, James W. Hodge, Jeffrey Schlom, Sofia R. Gameiro, Clint T. Allen

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-12 (2018)

Abstract Background Natural killer (NK) cells recognize and lyse target tumor cells in an MHC-unrestricted fashion and complement antigen- and MHC-restricted killing by T-lymphocytes. NK cells and T-lymphocytes mediate early killing of targets throug

Externí odkaz: https://doaj.org/article/9452867cafaa4abaadb8103de56db9b3

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Supplemental Methods from Enhanced Tumor Control with Combination mTOR and PD-L1 Inhibition in Syngeneic Oral Cavity Cancers

Autor: Clint T. Allen, Carter Van Waes, James W. Hodge, Ravindra Uppaluri, Andria M. Caruso, Harrison A. Cash, Ellen C. Moore

This file contains detailed methods for both our in vivo animal and flow cytometry experiments. This includes drug doses and scheduling, an inventory of antibodies, and appropriate supporting references.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7233fe1a437e3c7d8ed9c70542604c6e
https://doi.org/10.1158/2326-6066.22537364.v1

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Supplementary Figures 1 through 4 from Enhanced Tumor Control with Combination mTOR and PD-L1 Inhibition in Syngeneic Oral Cavity Cancers

Autor: Clint T. Allen, Carter Van Waes, James W. Hodge, Ravindra Uppaluri, Andria M. Caruso, Harrison A. Cash, Ellen C. Moore

Contains supplemental figures 1 through 4 and their corresponding legends. Suppl Fig 1 demonstrates summary growth curves for in vivo MOC1 and MOC2 experiments. Suppl Fig 2 is validation of p15E antigen expression in MOC cell lines. Supple Fig 3 demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c14a08badb9d9de55d41eb94551f975
https://doi.org/10.1158/2326-6066.22537361.v1

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Data from Enhanced Tumor Control with Combination mTOR and PD-L1 Inhibition in Syngeneic Oral Cavity Cancers

Autor: Clint T. Allen, Carter Van Waes, James W. Hodge, Ravindra Uppaluri, Andria M. Caruso, Harrison A. Cash, Ellen C. Moore

Significant subsets of patients with oral cancer fail to respond to single-agent programmed death (PD) blockade. Syngeneic models of oral cancer were used to determine if blocking oncogenic signaling improved in vivo responses to PD-L1 monoclonal ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfc971743fb536ba9999cb53b08ce81e
https://doi.org/10.1158/2326-6066.c.6548414.v1

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Data from Semaphorin4D Inhibition Improves Response to Immune-Checkpoint Blockade via Attenuation of MDSC Recruitment and Function

Autor: Clint T. Allen, Elizabeth E. Evans, Maurice Zauderer, Ernest Smith, Ellen C. Moore, Yvette Robbins, Jay Friedman, Paul E. Clavijo

Tumor infiltration by immunosuppressive myeloid cells, such as myeloid-derived suppressor cells (MDSCs), causes resistance to immunotherapy. Semaphorin4D, originally characterized for its axonal guidance properties, also contributes to endothelial ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::458388c807fc35990be5c43bdeb12d22
https://doi.org/10.1158/2326-6066.c.6549047.v1

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Supplementary Figures and Legends from Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3Kδ/γ

Autor: Clint Allen, Carter Van Waes, Chris Silvin, Zhong Chen, Harrison Cash, Jay Friedman, Paul E. Clavijo, Ellen C. Moore, Ruth J. Davis

The supplemental figures demonstrate data supportive of the overall conclusions of this manuscript including MDSC flow cytometry gating strategy, evidence for moderate suppression of peripheral MDSC T-lymphocyte suppressive capacity after IPI-145 mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be2d62a9996ce9a40d930f82060185e
https://doi.org/10.1158/0008-5472.22413357.v1

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Data from Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3Kδ/γ

Autor: Clint Allen, Carter Van Waes, Chris Silvin, Zhong Chen, Harrison Cash, Jay Friedman, Paul E. Clavijo, Ellen C. Moore, Ruth J. Davis

Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations and a T-cell–inflamed phenotype. One significant barrier to efficacy may be the recruitment of myeloid-derived suppressor cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d258e30e44a79aec8e3c9cdc9d8a8ba
https://doi.org/10.1158/0008-5472.c.6508692.v1

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