Vitamin K intake and status are low in hemodialysis patients

Autor: Elke J. Magdeleyns, Gozewijn D. Laverman, Herma H. Uiterwijk, Ellen C. M. Cranenburg, Ralf Westerhuis, G.W. Dalmeijer, Joline W.J. Beulens, Cees Vermeer, Leon J. Schurgers, Marjolein Herfs

Publikováno v: Cranenburg, E C M, Schurgers, L J, Uiterwijk, H H, Beulens, J W J, Dalmeijer, G W, Westerhuis, R, Magdeleyns, E J, Herfs, M, Vermeer, C & Laverman, G D 2012, ' Vitamin K intake and status are low in hemodialysis patients ', Kidney International, vol. 82, no. 5, pp. 605-610 . https://doi.org/10.1038/ki.2012.191
Kidney International, 82(5), 605-610. ELSEVIER SCIENCE INC
Kidney International, 82(5), 605-610. Elsevier Science
Kidney International, 82(5), 605-610. Nature Publishing Group

Vitamin K is essential for the activity of γ-carboxyglutamate (Gla)-proteins including matrix Gla28 protein and osteocalcin; an inhibitor of vascular calcification and a bone matrix protein, respectively. Insufficient vitamin K intake leads to the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6416cfbf6c0c50709ae6cb39474782
https://doi.org/10.1038/ki.2012.191

Association of kidney function and uncarboxylated matrix Gla protein: Data from the Heart and Soul Study

Autor: Mary A. Whooley, Cees Vermeer, Joachim H. Ix, Benjamin D. Parker, Ellen C. M. Cranenburg, Leon J. Schurgers

Publikováno v: Nephrology Dialysis Transplantation. 24:2095-2101

Vascular calcification is highly prevalent in persons with chronic kidney disease (CKD) and predicts cardiovascular disease (CVD) events. Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification, and lower levels of its precursor-unca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c0756689eb138d7e88d94702d4c5de
https://doi.org/10.1093/ndt/gfp024

Matrix Gla-protein: The calcification inhibitor in need of vitamin K

Autor: Ellen C. M. Cranenburg, Cees Vermeer, Leon J. Schurgers

Publikováno v: Thrombosis and Haemostasis. 100:593-603

SummaryAmong the proteins involved in vascular calcium metabolism, the vitamin K-dependent matrix Gla-protein (MGP) plays a dominant role. Although on a molecular level its mechanism of action is not completely understood, it is generally accepted th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::998656fdd0a532ca044a2b3678179c80
https://doi.org/10.1160/th08-02-0087

Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species

Autor: Otto Bekers, Ralf Koos, Leon J. Schurgers, Robert Landewé, Thea Schoonbrood, Elke J. Magdeleyns, Ellen C. M. Cranenburg, Cees Vermeer, Vincent Brandenburg

Publikováno v: Thrombosis and haemostasis, 104(4), 811-822. Schattauer GmbH
Thrombosis and Haemostasis, 104(4), 811-822. Georg Thieme Verlag

SummaryMatrix γ-carboxyglutamate (Gla) protein (MGP) is an important local inhibitor of vascular calcification, which can undergo two post-translational modifications: vitamin K-dependent γ-glutamate carboxylation and serine phosphorylation. While

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2921aee79d9af2b7f5b2992fd0427d
https://pubmed.ncbi.nlm.nih.gov/20694284

Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients

Autor: Ellen C M, Cranenburg, Vincent M, Brandenburg, Cees, Vermeer, Melanie, Stenger, Georg, Mühlenbruch, Andreas H, Mahnken, Ulrich, Gladziwa, Markus, Ketteler, Leon J, Schurgers

Publikováno v: Thrombosis and haemostasis. 101(2)

Matrix gamma-carboxyglutamate (Gla) protein (MGP) is a potent local inhibitor of cardiovascular calcification and accumulates at areas of calcification in its uncarboxylated form (ucMGP). We previously found significantly lower circulating ucMGP leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74cc0c5e610ffad43eade1be146e6605
https://pubmed.ncbi.nlm.nih.gov/19190822