Výsledky vyhledávání - "Ellen C. Henry"

Akademický článek

Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells

Autor: Zeenath Unnisa, Kameshwar P. Singh, Ellen C. Henry, Catherine L. Donegan, John A. Bennett, Thomas A. Gasiewicz

Publikováno v: Stem Cells International, Vol 2016 (2016)

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor belonging to the Per-Arnt-Sim (PAS) family of proteins. The AHR is involved in hematopoietic stem cell (HSC) functions including self-renewal, proliferation, quiescence, a

Externí odkaz: https://doaj.org/article/a400f50bcad84510bcf0f6a7f497bd02

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Supplemental Methods, Figure 1, Tables 1A and B from The Heat Shock Protein 90 Inhibitor, (−)-Epigallocatechin Gallate, Has Anticancer Activity in a Novel Human Prostate Cancer Progression Model

Autor: Thomas A. Gasiewicz, William A. Ricke, Ellen C. Henry, Michael A. Moses

Supplemental Methods, Figure 1, Tables 1A and B. Supplemental Figure 1: Chaperone function assay; Supplemental Table 1A: Densitrometry analysis of HSP90-clients in response to EGCG; Supplemental Table 1B: Densitometry analysis of HSP90-clients in non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a439d327ddd032d2b29bf83be16f0d
https://doi.org/10.1158/1940-6207.22525821

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Data from The Heat Shock Protein 90 Inhibitor, (−)-Epigallocatechin Gallate, Has Anticancer Activity in a Novel Human Prostate Cancer Progression Model

Autor: Thomas A. Gasiewicz, William A. Ricke, Ellen C. Henry, Michael A. Moses

(−)-Epigallocatechin gallate (EGCG), a major tea polyphenol, elicits anticancer effects. However, the mechanism of action is not fully understood. Our laboratory previously showed that EGCG inhibits heat shock protein 90 (HSP90). We used nontumorig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10962aeea606c85148c349fcd2bfa196
https://doi.org/10.1158/1940-6207.c.6544923

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The Heat Shock Protein 90 Inhibitor, (−)-Epigallocatechin Gallate, Has Anticancer Activity in a Novel Human Prostate Cancer Progression Model

Autor: William A. Ricke, Ellen C. Henry, Thomas A. Gasiewicz, Michael A. Moses

Publikováno v: Cancer Prevention Research. 8:249-257

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d328bab793cbe67ef421d909f2e951
https://doi.org/10.1158/1940-6207.capr-14-0224

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Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells

Autor: Catherine L. Donegan, Thomas A. Gasiewicz, Zeenath Unnisa, Ellen C. Henry, Kameshwar P. Singh, John A. Bennett

Publikováno v: Stem Cells International, Vol 2016 (2016)
Stem Cells International

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00659735b2778bc6385e74ef106402f8

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TCDD and a Putative Endogenous AhR Ligand, ITE, Elicit the Same Immediate Changes in Gene Expression in Mouse Lung Fibroblasts

Autor: Ellen C. Henry, Thomas A. Gasiewicz, Stephen Welle

Publikováno v: Toxicological Sciences. 114:90-100

Although the aryl hydrocarbon receptor (AhR) has been most extensively studied as a mediator of toxicity of several classes of environmental contaminants, it is also recognized as having important endogenous functions. For example, in its absence (in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db235c70705ecd30140a9fe31305a217
https://doi.org/10.1093/toxsci/kfp285

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(−)-Epigallocatechin-3-gallate Is a Novel Hsp90 Inhibitor

Autor: Zhengyu Yin, Thomas A. Gasiewicz, Ellen C. Henry

Publikováno v: Biochemistry. 48:336-345

(-)-Epigallocatechin-3-gallate (EGCG), a major component of green tea, protects against certain types of cancers, although the mechanism has not yet been determined. It was previously demonstrated that EGCG blocks aryl hydrocarbon receptor (AhR)-medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b472cd0730ef06a58e3df90a47817a
https://doi.org/10.1021/bi801637q

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Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor

Autor: Ellen C. Henry, Thomas A. Gasiewicz

Publikováno v: Archives of Biochemistry and Biophysics. 472:77-88

The aryl hydrocarbon receptor (AhR) mediates the toxicity of dioxins and related xenobiotics. Other chemicals also bind the AhR to elicit either agonist or antagonist responses. Here we used site-directed mutagenesis within the ligand binding domain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235b2b1eea2b65c045a2b7fd1eae38c8
https://doi.org/10.1016/j.abb.2008.02.005

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Expression and Activity of Aryl Hydrocarbon Receptors in Development and Cancer

Autor: Loretta L. Collins, Ellen C. Henry, Thomas A. Gasiewicz

Publikováno v: Critical Reviews™ in Eukaryotic Gene Expression. 18:279-321

Although the aryl hydrocarbon receptor (AhR) has been known as the mediator of the toxicity of particular xenobiotics such as the dioxins, the normal role of this transcription factor in a number of biological processes is just beginning to be recogn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680f0c35fbf078d2202c00be4143fff5
https://doi.org/10.1615/critreveukargeneexpr.v18.i4.10

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