Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ellen C. Gleeson"'
Autor:
Ellen C. Gleeson, Janease E. Graham, Sandro Spiller, Irina Vetter, Richard J. Lewis, Peter J. Duggan, Kellie L. Tuck
Publikováno v:
Marine Drugs, Vol 13, Iss 4, Pp 2030-2045 (2015)
A set of fluorophenoxyanilides, designed to be simplified analogues of previously reported ω-conotoxin GVIA mimetics, were prepared and tested for N-type calcium channel inhibition in a SH-SY5Y neuroblastoma FLIPR assay. N-type or Cav2.2 channel is
Externí odkaz:
https://doaj.org/article/2cdb44de3de74a758f7860ce4082332a
Autor:
Amy L. Thomson, Ellen C. Gleeson, Alessia Belgi, W. Roy Jackson, Ekaterina I. Izgorodina, Andrea J. Robinson
Publikováno v:
Chemical Communications.
In-situ masking of sulfur-containing residues ensures productive Ru-alkylidene catalysed olefin metathesis to generate metabolically stable cystine bridge peptidomimetics with defined geometry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a62d9e940279849263c3acc3194bfdb2
https://doi.org/10.1039/d3cc01476b
https://doi.org/10.1039/d3cc01476b
Autor:
Jeffrey R. McArthur, Sandro Spiller, Peter J. Duggan, Ellen C Gleeson, Kellie L. Tuck, Richard J. Lewis, Leonid Motin, David J. Adams
Publikováno v:
British Journal of Pharmacology. 175:2284-2295
Background and purpose Voltage-gated calcium channels are involved in nociception in the CNS and in the periphery. N-type (Cav 2.2) and T-type (Cav 3.1, Cav 3.2 and Cav 3.3) voltage-gated calcium channels are particularly important in studying and tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79ac989dbc52554501fb8cbb89d78355
https://doi.org/10.1111/bph.13910
https://doi.org/10.1111/bph.13910
Publikováno v:
Chemical Communications. 53:9769-9772
An efficient and expedient route to the synthesis of dicarba peptides from protecting group-free sequences is reported using Ru-alkylidene catalysed olefin metathesis. A range of cyclic peptides was prepared from linear peptides containing two Z-crot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b44e894a1c4501cc9147a1781863b30
https://doi.org/10.1039/c7cc04100d
https://doi.org/10.1039/c7cc04100d
Publikováno v:
Tetrahedron Letters. 57:4325-4333
This review highlights developments in the field of ring-closing metathesis applied to the synthesis of cyclic peptides. Special attention is focussed on the synthesis of dicarba peptides that mimic native cystine containing peptides. Recent advances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03c76557cbb9f53adfaff759c975ac73
https://doi.org/10.1016/j.tetlet.2016.08.032
https://doi.org/10.1016/j.tetlet.2016.08.032
Publikováno v:
The Journal of Organic Chemistry. 80:7205-7211
A simple and generic approach to access a new family of Ru-alkylidene olefin metathesis catalysts with specialized properties is reported. This strategy utilizes a late stage, utilitarian Hoveyda-type ligand derived from tyrosine, which can be access
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2836f41dc06fbbb295ceb6bd94be1c71
https://doi.org/10.1021/acs.joc.5b01091
https://doi.org/10.1021/acs.joc.5b01091
Autor:
Peter J. Duggan, Sandro Spiller, Richard J. Lewis, Ellen C Gleeson, Kellie L. Tuck, Janease Erin Graham, Irina Vetter
Publikováno v:
Marine Drugs
Marine Drugs, Vol 13, Iss 4, Pp 2030-2045 (2015)
Volume 13
Issue 4
Pages 2030-2045
Marine Drugs, Vol 13, Iss 4, Pp 2030-2045 (2015)
Volume 13
Issue 4
Pages 2030-2045
A set of fluorophenoxyanilides, designed to be simplified analogues of previously reported ω-conotoxin GVIA mimetics, were prepared and tested for N-type calcium channel inhibition in a SH-SY5Y neuroblastoma FLIPR assay. N-type or Cav2.2 channel is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43789c2e06af8663af1577dbb910d70d
http://europepmc.org/articles/PMC4413198
http://europepmc.org/articles/PMC4413198
Autor:
Luke A. Adams, Pooja Sharma, Biswaranjan Mohanty, Olga V. Ilyichova, Mark D. Mulcair, Martin L. Williams, Ellen C. Gleeson, Makrina Totsika, Bradley C. Doak, Sofia Caria, Kieran Rimmer, James Horne, Stephen R. Shouldice, Mansha Vazirani, Stephen J. Headey, Brent R. Plumb, Jennifer L. Martin, Begoña Heras, Jamie S. Simpson, Martin J. Scanlon
Publikováno v:
Angewandte Chemie. 127:2207-2212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a20d8301f8e7a018ce51adce13b6487b
https://doi.org/10.1002/ange.201410341
https://doi.org/10.1002/ange.201410341
Publikováno v:
ChemInform. 47
This review highlights developments in the field of ring-closing metathesis applied to the synthesis of cyclic peptides. Special attention is focussed on the synthesis of dicarba peptides that mimic native cystine containing peptides. Recent advances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ca78f6bcf77fb62fa7e3e6b05af4170
https://doi.org/10.1002/chin.201645209
https://doi.org/10.1002/chin.201645209
Autor:
Sandeep Chhabra, Samuel D. Robinson, Raymond S. Norton, W. Roy Jackson, Christopher A. MacRaild, Andrea J. Robinson, Zhen J. Wang, Ellen C. Gleeson
Publikováno v:
Chemical communications (Cambridge, England). 52(24)
A facile stereoselective synthesis of cis and trans unsaturated dicarba peptides has been established using preformed diaminosuberic acid derivatives as bridging units. In addition, characteristic spectral differences in the (13)C-NMR spectra of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2cee87a6b83355b27db6efb7ca2d665
https://pubmed.ncbi.nlm.nih.gov/26892179
https://pubmed.ncbi.nlm.nih.gov/26892179