Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ellen Brenner"'
Autor:
Ellen Brenner, Barbara F. Schörg, Fatima Ahmetlić, Thomas Wieder, Franz Joachim Hilke, Nadine Simon, Christopher Schroeder, German Demidov, Tanja Riedel, Birgit Fehrenbacher, Martin Schaller, Andrea Forschner, Thomas Eigentler, Heike Niessner, Tobias Sinnberg, Katharina S. Böhm, Nadine Hömberg, Heidi Braumüller, Daniel Dauch, Stefan Zwirner, Lars Zender, Dominik Sonanini, Albert Geishauser, Jürgen Bauer, Martin Eichner, Katja J. Jarick, Andreas Beilhack, Saskia Biskup, Dennis Döcker, Dirk Schadendorf, Leticia Quintanilla-Martinez, Bernd J. Pichler, Manfred Kneilling, Ralph Mocikat, Martin Röcken
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
The growth of cancer cells can be stably arrested by cytokine-induced senescence. Here, the authors show that cancers with defects in senescence-inducing cell cycle regulator pathways are resistant to immune checkpoint blockade.
Externí odkaz:
https://doaj.org/article/ffeefb0c18174583b0c353a1c64a24f9
Autor:
Vera Bauer, Tanja Riedel, Ralph Mocikat, Fatima Ahmetlic, Josia Fauser, Carolin Flessner, Nadine Hömberg, Roman Hennel, Ellen Brenner, Kirsten Lauber
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Background Although antibodies blocking immune checkpoints have already been approved for clinical cancer treatment, the mechanisms involved are not yet completely elucidated. Here we used a λ-MYC transgenic model of endogenously growing B-cell lymp
Externí odkaz:
https://doaj.org/article/4259eb19d88447d2a363554ef982c306
IFN-γ and TNF Induce Senescence and a Distinct Senescence-Associated Secretory Phenotype in Melanoma
Autor:
Lorenzo Homann, Maximilian Rentschler, Ellen Brenner, Katharina Böhm, Martin Röcken, Thomas Wieder
Publikováno v:
Cells, Vol 11, Iss 9, p 1514 (2022)
Immune checkpoint blockade (ICB) therapy is a central pillar of melanoma treatment leading to durable response rates. Important mechanisms of action of ICB therapy include disinhibition of CD4+ and CD8+ T cells. Stimulated CD4+ T helper 1 cells secre
Externí odkaz:
https://doaj.org/article/dccbe97fd16e4b11b220ea6fe519faaf
Autor:
Maximilian Rentschler, Yan Chen, Jana Pahl, Laura Soria-Martinez, Heidi Braumüller, Ellen Brenner, Oliver Bischof, Martin Röcken, Thomas Wieder
Publikováno v:
Cellular Physiology and Biochemistry, Vol 51, Iss 3, Pp 1103-1118 (2018)
Background/Aims: Cellular senescence, or permanent growth arrest, is known as an effective tumor suppressor mechanism that can be induced by different stressors, such as oncogenes, chemotherapeutics or cytokine cocktails. Previous studies demonstrate
Externí odkaz:
https://doaj.org/article/4340da49bee64918abab59a9f9c4ee9d
IFN-γ and TNF Induce Senescence and a Distinct Senescence-Associated Secretory Phenotype in Melanoma
Autor:
Wieder, Lorenzo Homann, Maximilian Rentschler, Ellen Brenner, Katharina Böhm, Martin Röcken, Thomas
Publikováno v:
Cells; Volume 11; Issue 9; Pages: 1514
Immune checkpoint blockade (ICB) therapy is a central pillar of melanoma treatment leading to durable response rates. Important mechanisms of action of ICB therapy include disinhibition of CD4+ and CD8+ T cells. Stimulated CD4+ T helper 1 cells secre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::c20f0eca689de7876015661b5f8fdf60
Autor:
Ellen Brenner, Martin Röcken
Publikováno v:
The Journal of investigative dermatology. 142(8)
Melanomas are malignant tumors that can partly and very rarely completely regress in response to immune responses. Analyzing the mechanisms underlying this immune-mediated rejection, melanomas became leading in developing general cancer immunotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8090ddbe77148c1370e5ca773fd033de
https://pubmed.ncbi.nlm.nih.gov/35339277
https://pubmed.ncbi.nlm.nih.gov/35339277
Publikováno v:
Peritoneal Tumors and Metastases ISBN: 9783030626396
Immune responses may control tumorigenesis and metastasis. Most antitumor interventions have been designed to boost the immune system in its fight to destroy cancerous cells. In the last decades, the biological mechanisms of tumor immune control have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6530bc26de740367f374a8b39e68098
https://doi.org/10.1007/978-3-030-62640-2_14
https://doi.org/10.1007/978-3-030-62640-2_14
Autor:
Albert Geishauser, Andreas Beilhack, Tanja Riedel, Bernd J. Pichler, Jürgen Bauer, Nadine Simon, Fatima Ahmetlić, Heidi Braumüller, Saskia Biskup, Nadine Hömberg, Martin Schaller, Dennis Döcker, Christopher Schroeder, Lars Zender, Andrea Forschner, Franz J. Hilke, Manfred Kneilling, Thomas Eigentler, Katharina Böhm, Ellen Brenner, Dirk Schadendorf, Birgit Fehrenbacher, Stefan Zwirner, B.F. Schörg, German Demidov, Martin Eichner, Thomas Wieder, Heike Niessner, Leticia Quintanilla-Martinez, Tobias Sinnberg, Ralph Mocikat, Martin Röcken, Dominik Sonanini, Daniel Dauch, Katja J. Jarick
Publikováno v:
Nat. Commun. 11:1335 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications
Immune checkpoint blockade (ICB)-based or natural cancer immune responses largely eliminate tumours. Yet, they require additional mechanisms to arrest those cancer cells that are not rejected. Cytokine-induced senescence (CIS) can stably arrest cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a6fc7f2a9ae75483c50433edab7d47
https://doi.org/10.1038/s41467-020-14987-6
https://doi.org/10.1038/s41467-020-14987-6
Publikováno v:
Journal of Investigative Dermatology. 141:S193
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0da46c3d108d37f5d2819a2a33e59842
https://doi.org/10.1016/j.jid.2021.08.269
https://doi.org/10.1016/j.jid.2021.08.269