Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Ellen Aasum"'
Autor:
Synne S. Hansen, Tina M. Pedersen, Julie Marin, Neoma T. Boardman, Ajay M. Shah, Ellen Aasum, Anne D. Hafstad
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 143 (2022)
The present study aimed to examine the effects of low doses of angiotensin II (AngII) on cardiac function, myocardial substrate utilization, energetics, and mitochondrial function in C57Bl/6J mice and in a transgenic mouse model with cardiomyocyte sp
Externí odkaz:
https://doaj.org/article/a8cc8b62aa584c88b7bb9c53c348cdab
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Physical activity is an efficient strategy to delay development of obesity and insulin resistance, and thus the progression of obesity/diabetes-related cardiomyopathy. In support of this, experimental studies using animal models of obesity show that
Externí odkaz:
https://doaj.org/article/72232bbd2e954c75a757159cbd9fcfeb
Autor:
Anne D. Hafstad, Synne S. Hansen, Jim Lund, Celio X. C. Santos, Neoma T. Boardman, Ajay M. Shah, Ellen Aasum
Publikováno v:
Antioxidants, Vol 9, Iss 2, p 171 (2020)
Obesity and diabetes are independent risk factors for cardiovascular diseases, and they are associated with the development of a specific cardiomyopathy with elevated myocardial oxygen consumption (MVO2) and impaired cardiac efficiency. Although the
Externí odkaz:
https://doaj.org/article/1fb90a1ebc844e6baaf60edeff69b121
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204843 (2018)
Although murine models for studying the development of cardiac dysfunction in diabetes mellitus are well established, their reported cardiac phenotypes vary. These reported divergences may, in addition to the severity of different models, also be lin
Externí odkaz:
https://doaj.org/article/c2c4f35165a6487dbea2094e2389697d
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 319(3)
An ischemic insult is accompanied by an acute increase in circulating fatty acid (FA) levels, which can induce adverse changes related to cardiac metabolism/energetics. Although chronic hyperlipidemia contributes to the pathogenesis of obesity-/diabe
Autor:
Jim Lund, Ajay M. Shah, Celio X.C. Santos, Synne Simonsen Hansen, Anne D. Hafstad, Neoma T. Boardman, Ellen Aasum
Publikováno v:
Antioxidants
Volume 9
Issue 2
Antioxidants, Vol 9, Iss 2, p 171 (2020)
Volume 9
Issue 2
Antioxidants, Vol 9, Iss 2, p 171 (2020)
Obesity and diabetes are independent risk factors for cardiovascular diseases, and they are associated with the development of a specific cardiomyopathy with elevated myocardial oxygen consumption (MVO2) and impaired cardiac efficiency. Although the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18188559e5352107c47c28001b01fd6
https://hdl.handle.net/10037/20596
https://hdl.handle.net/10037/20596
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1864:1908-1913
Systemic changes during diabetes such as high glucose, dyslipidemia, hormonal changes and low grade inflammation, are believed to induce structural and functional changes in the cardiomyocyte associated with the development of diabetic cardiomyopathy
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 10 (2019)
Frontiers in Physiology, Vol 10 (2019)
Source at https://doi.org/10.3389/fphys.2019.01274. Physical activity is an efficient strategy to delay development of obesity and insulin resistance, and thus the progression of obesity/diabetes-related cardiomyopathy. In support of this, experiment
Autor:
Dunja Aksentijevic, Ellen Aasum, Damian J. Tyler, Maria da Luz Sousa Fialho, Lisa C. Heather, Trine Lund, L Mansor, Carolyn A. Carr, Lydia M. Le Page, Kieran Clarke, Keshavi Mehta, Mark A. Cole, Michael J. Shattock
Publikováno v:
The Journal of Physiology. 594:307-320
Hypoxia activates the hypoxia-inducible factor (HIF), promoting glycolysis and suppressing mitochondrial respiration. In the type 2 diabetic heart, glycolysis is suppressed whereas fatty acid metabolism is promoted. The diabetic heart experiences chr
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204843 (2018)
PLoS ONE
PLoS ONE
Source at https://doi.org/10.1371/journal.pone.0204843. Although murine models for studying the development of cardiac dysfunction in diabetes mellitus are well established, their reported cardiac phenotypes vary. These reported divergences may, in a