Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Ellen A. Weiss"'
In the vertebrate retina, phosphorylation of photoactivated visual pigments in rods and cones by G protein-coupled receptor kinases is essential for sustained visual function. In vitro analysis demonstrates that GRK1 and GRK7 are phosphorylated by PK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9f43215299f274bdaa6154fd40a58a1
https://doi.org/10.1101/2022.06.23.497385
https://doi.org/10.1101/2022.06.23.497385
Publikováno v:
Mol Ther
The use of gene therapy may allow replacement of the defective gene. Minigenes, such as cDNAs, are often used. However, these may not express normal physiological genetic profiles due to lack of crucial endogenous regulatory elements. We constructed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f417bc7ab1f7e466bf550449e150b6e3
https://doi.org/10.1016/j.ymthe.2019.11.031
https://doi.org/10.1016/j.ymthe.2019.11.031
Publikováno v:
Journal of Biological Chemistry. 298:102636
In the vertebrate retina, phosphorylation of photoactivated visual pigments in rods and cones by G protein-coupled receptor kinases (GRKs) is essential for sustained visual function. Previous in vitro analysis demonstrated that GRK1 and GRK7 are phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f04b091cfa248cc16dc145e33072f1
https://doi.org/10.1016/j.jbc.2022.102636
https://doi.org/10.1016/j.jbc.2022.102636
Autor:
Ellen R. Weiss, Jared D. Chrispell, Shoji Osawa, Vladimir J. Kefalov, Alexander V. Kolesnikov
Publikováno v:
FASEB J
Timely recovery of the light response in photoreceptors requires efficient inactivation of photoactivated rhodopsin. This process is initiated by phosphorylation of its carboxyl terminus by G protein-coupled receptor kinase 1 (GRK1). Previously, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65271ffc9da1a75734af9726640d639b
https://doi.org/10.1096/fj.201902535r
https://doi.org/10.1096/fj.201902535r
Autor:
Carolyn A. Munson, Isis Trujillo-Gonzalez, Wei Sha, Ellen R. Weiss, Nazia M. Alam, Natalia Surzenko, Amelia Bachleda, Steven H. Zeisel, Walter B. Friday
Publikováno v:
FASEB J
Adequate supply of choline, an essential nutrient, is necessary to support proper brain development. Whether prenatal choline availability plays a role in development of the visual system is currently unknown. In this study, we addressed the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183c244c7e699150cd1cc44bda9a1856
https://doi.org/10.1096/fj.201900444r
https://doi.org/10.1096/fj.201900444r
Autor:
Ellen R. Weiss
Publikováno v:
The biochemist
The retina is famous for its ability to operate under a broad range of light intensities. This is partly due to the presence of two types of photoreceptor cells, rods and cones. Rods are used mostly for dim light vision, and cones are used for bright
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d168adecbe8d06b2c792bc0e79f315
https://pubmed.ncbi.nlm.nih.gov/33840915
https://pubmed.ncbi.nlm.nih.gov/33840915
Publikováno v:
Biomaterials. 157:26-39
Retinitis pigmentosa (RP) is a group of inherited retinal degenerative conditions and a leading cause of irreversible blindness. 25%–30% of RP cases are caused by inherited autosomal dominant (ad) mutations in the rhodopsin (Rho) protein of the ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afcba0099acf577be4424d6729dc635f
https://doi.org/10.1016/j.biomaterials.2017.12.004
https://doi.org/10.1016/j.biomaterials.2017.12.004
Autor:
John Paul Gaylor, Katharine J. Liang, Kenton T. Woodard, Mark A. Weaver, R. Jude Samulski, Ellen R. Weiss
Publikováno v:
Molecular Therapy. 25:765-779
NRF2 is a transcription factor that drives antioxidant gene expression in multiple organ systems. We hypothesized that Nrf2 overexpression could be therapeutically applied toward diseases in which redox homeostasis is disrupted. In this study, adeno-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e277a1ba797a796baa785e4aafbac2
https://doi.org/10.1016/j.ymthe.2016.12.016
https://doi.org/10.1016/j.ymthe.2016.12.016
Autor:
Timothy R. Fennell, Susan McRitchie, Ellen R. Weiss, James Carlson, Shoji Osawa, Suraj Dhungana, Yubin Xiong
Publikováno v:
Exp Eye Res
Retinitis pigmentosa (RP) is a degenerative disease of the retina that affects approximately 1 million people worldwide. There are multiple genetic causes of this disease, for which, at present, there are no effective therapeutic strategies. In the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817feb74ee2b0a09cdd312374e32f2fa
https://europepmc.org/articles/PMC6570542/
https://europepmc.org/articles/PMC6570542/
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Muller glia (MG), the principal glial cells of the vertebrate retina, display quiescent progenitor cell characteristics. They express key progenitor markers, including the high mobility group box transcription factor SOX2 and maintain a proge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297943a8019a84103f7438a279e14217
https://pubmed.ncbi.nlm.nih.gov/27031842
https://pubmed.ncbi.nlm.nih.gov/27031842