Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Ellen A, Robey"'
Autor:
Chan-Su Park, Jian Guan, Peter Rhee, Federico Gonzalez, Hee-sung Lee, Ji-hyun Park, Laurent Coscoy, Ellen A Robey, Nilabh Shastri, Scheherazade Sadegh-Nasseri
Publikováno v:
eLife, Vol 13 (2024)
The fate of developing T cells is determined by the strength of T cell receptor (TCR) signal they receive in the thymus. This process is finely regulated through the tuning of positive and negative regulators in thymocytes. The Family with sequence s
Externí odkaz:
https://doaj.org/article/5dac43e64dda4b1c805566d173e337bf
Autor:
Jian Guan, J David Peske, Michael Manoharan Valerio, Chansu Park, Ellen A Robey, Scheherazade Sadegh-Nasseri
Publikováno v:
eLife, Vol 12 (2023)
Intestinal intraepithelial lymphocytes (IELs) are characterized by an unusual phenotype and developmental pathway, yet their specific ligands and functions remain largely unknown. Here by analysis of QFL T cells, a population of CD8+ T cells critical
Externí odkaz:
https://doaj.org/article/54430899bea94fd7b55a65b2c274a757
Autor:
Michael Manoharan Valerio, Kathya Arana, Jian Guan, Shiao Wei Chan, Xiaokun Yang, Nadia Kurd, Angus Lee, Nilabh Shastri, Laurent Coscoy, Ellen A. Robey
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
MHC-E restricted CD8 T cells show promise in vaccine settings, but their development and specificity remain poorly understood. Here we focus on a CD8 T cell population reactive to a self-peptide (FL9) bound to mouse MHC-E (Qa-1b) that is presented in
Externí odkaz:
https://doaj.org/article/39ecc32a95a34e96b4b07cd3ca823fbb
Autor:
Kristina M. Geiger, Michael Manoharan, Rachel Coombs, Kathya Arana, Chan-Su Park, Angus Y. Lee, Nilabh Shastri, Ellen A. Robey, Laurent Coscoy
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112317- (2023)
Summary: The endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP) plays a crucial role in shaping the peptide-major histocompatibility complex (MHC) class I repertoire and maintaining immune surveillance. While murine cytom
Externí odkaz:
https://doaj.org/article/1eb0def2d54145d79e3f806380bb3bbe
Autor:
Tyng-An Zhou, Hsuan-Po Hsu, Yueh-Hua Tu, Hui-Kuei Cheng, Chih-Yu Lin, Nien-Jung Chen, Jin-Wu Tsai, Ellen A Robey, Hsuan-Cheng Huang, Chia-Lin Hsu, Ivan L Dzhagalov
Publikováno v:
eLife, Vol 11 (2022)
Tissue-resident macrophages are essential to protect from pathogen invasion and maintain organ homeostasis. The ability of thymic macrophages to engulf apoptotic thymocytes is well appreciated, but little is known about their ontogeny, maintenance, a
Externí odkaz:
https://doaj.org/article/e2be2a7d17c844db955442ecde1ea243
Autor:
Yang Wang, Alexandra Tsitsiklis, Stephanie Devoe, Wei Gao, H. Hamlet Chu, Yan Zhang, Wei Li, Wing Ki Wong, Charlotte M. Deane, David Neau, Jill E. Slansky, Paul G. Thomas, Ellen A. Robey, Shaodong Dai
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified by elite control of HIV in individuals harboring HLA-B57. To understand the structural features that contribute to CD8 T cell elite control, we focused o
Externí odkaz:
https://doaj.org/article/7ffa5a501e02421090f8abaab1877c09
Autor:
Lydia K Lutes, Zoë Steier, Laura L McIntyre, Shraddha Pandey, James Kaminski, Ashley R Hoover, Silvia Ariotti, Aaron Streets, Nir Yosef, Ellen A Robey
Publikováno v:
eLife, Vol 10 (2021)
Functional tuning of T cells based on their degree of self-reactivity is established during positive selection in the thymus, although how positive selection differs for thymocytes with relatively low versus high self-reactivity is unclear. In additi
Externí odkaz:
https://doaj.org/article/7576a36ea73d437fbdb9d9b7a5263164
Autor:
Alexandra Tsitsiklis, Derek J. Bangs, Lydia K. Lutes, Shiao W. Chan, Kristina M. Geiger, Andrew J. Modzelewski, Lara Labarta-Bajo, Yang Wang, Elina I. Zuniga, Shaodong Dai, Ellen A. Robey
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The CD8+ T cell response to the intracellular parasite Toxoplasma gondii varies dramatically between mouse strains, resulting in stark differences in control of the parasite. Protection in BALB/c mice can be attributed to an unusually strong and prot
Externí odkaz:
https://doaj.org/article/4aa56ee319d5430d9240f09b8b10ac7c
Autor:
Nadia S Kurd, Lydia K Lutes, Jaewon Yoon, Shiao Wei Chan, Ivan L Dzhagalov, Ashley R Hoover, Ellen A Robey
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://doaj.org/article/bc3820e00e334aba90074c133f0dfb98
Autor:
Nadia S Kurd, Lydia K Lutes, Jaewon Yoon, Shiao Wei Chan, Ivan L Dzhagalov, Ashley R Hoover, Ellen A Robey
Publikováno v:
eLife, Vol 8 (2019)
Autoreactive thymocytes are eliminated during negative selection in the thymus, a process important for establishing self-tolerance. Thymic phagocytes serve to remove dead thymocytes, but whether they play additional roles during negative selection r
Externí odkaz:
https://doaj.org/article/fffba24565fc4ed5a994274e6a024134