Spatial control of protein phosphatase 2A (de)methylation

Autor: Veerle Janssens, Ellen Martens, Justin Vijay Louis, Sari Longin, Evelien Rondelez, Jozef Goris, Karen Zwaenepoel

Publikováno v: Experimental Cell Research. 314:68-81

Reversible methylation of the protein phosphatase 2A catalytic subunit (PP2A(C)(1)) is an important regulatory mechanism playing a crucial role in the selective recruitment of regulatory B subunits. Here, we investigated the subcellular localization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9d9f375ebdccbe63ac4e515f703e53
https://doi.org/10.1016/j.yexcr.2007.07.030

An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator

Autor: Veerle Janssens, Etienne Waelkens, Jozef Goris, Ivo De Baere, Rita Derua, Ellen Martens, Jan Jordens, Sari Longin, Christine Van Hoof, Evelien Rondelez, Ilse Stevens

Publikováno v: Biochemical Journal. 380:111-119

We have described recently the purification and cloning of PP2A (protein phosphatase 2A) leucine carboxylmethyltransferase. We studied the purification of a PP2A-specific methylesterase that co-purifies with PP2A and found that it is tightly associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfd9525c6adb2d9a060e44e36741c79
https://doi.org/10.1042/bj20031643

Mice lacking phosphatase PP2A subunit PR61/B'{delta} (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3{beta}

Autor: Jürgen Götz, Sari Longin, Guy Lippens, Justin Vijay Louis, Isabelle Landrieu, Peter Borghgraef, Fred Van Leuven, Veerle Janssens, R. Pijnenborg, Ellen Martens, Caroline Lambrecht, Ward Sents, Jozef Goris, Birgit Ledermann, Karen Zwaenepoel

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, epub ahead of print. ⟨10.1073/pnas.1018777108⟩
Proceedings of the National Academy of Sciences of the United States of America, 2011, epub ahead of print. ⟨10.1073/pnas.1018777108⟩

Functional diversity of protein phosphatase 2A (PP2A) enzymes mainly results from their association with distinct regulatory subunits. To analyze the functions of one such holoenzyme in vivo, we generated mice lacking PR61/B’δ (B56δ), a subunit h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f651dd1a3a90be7d68b7cb1e16e87f
https://hal.archives-ouvertes.fr/hal-00586855

Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice

Autor: Joris Vermeesch, Juergen Gotz, Ilse Stevens, Christine Van Hoof, Ellen Martens, Veerle Janssens, Jozef Goris

Publikováno v: Journal of molecular biology. 336(4)

Protein phosphatase 2A (PP2A) is a major serine/threonine-specific phosphatase playing central roles in development, cell growth and transformation. Regulation is largely accomplished by the regulatory B subunits, which determine substrate specificit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065ce54afc1c988a991a95cef9723297
https://pubmed.ncbi.nlm.nih.gov/15095873

Identification and characterization of B'-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues

Autor: Ilse, Stevens, Veerle, Janssens, Ellen, Martens, Stephen, Dilworth, Jozef, Goris, Christine, Van Hoof

Publikováno v: European journal of biochemistry. 270(2)

Protein phosphatase 2A is a phosphoserine/threonine phosphatase implicated in many cellular processes. The core enzyme comprises a catalytic and a PR65/A-subunit. The substrate specificity and subcellular localization are determined by a third regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c9fdc279d46c2f404852f5d56a4105d8
https://pubmed.ncbi.nlm.nih.gov/12605688