Paediatric obesity: a systematic review and pathway mapping of metabolic alterations underlying early disease processes

Autor: Margot De Spiegeleer, Ellen De Paepe, Lieven Van Meulebroek, Inge Gies, Jean De Schepper, Lynn Vanhaecke

Publikováno v: Molecular Medicine, Vol 27, Iss 1, Pp 1-20 (2021)

Abstract Background The alarming trend of paediatric obesity deserves our greatest awareness to hinder the early onset of metabolic complications impacting growth and functionality. Presently, insight into molecular mechanisms of childhood obesity an

Externí odkaz: https://doaj.org/article/33b7d44236af4b14b43acc0204bbfdf6

Bacillus Subtilis 29784 as a Feed Additive for Broilers Shifts the Intestinal Microbial Composition and Supports the Production of Hypoxanthine and Nicotinic Acid

Autor: Pearl Choi, Lamya Rhayat, Eric Pinloche, Estelle Devillard, Ellen De Paepe, Lynn Vanhaecke, Freddy Haesebrouck, Richard Ducatelle, Filip Van Immerseel, Evy Goossens

Publikováno v: Animals, Vol 11, Iss 5, p 1335 (2021)

The probiotic Bacillus subtilis strain 29784 (Bs29784) has been shown to improve performance in broilers. In this study, we used a metabolomic and 16S rRNA gene sequencing approach to evaluate effects of Bs29874 in the broiler intestine. Nicotinic ac

Externí odkaz: https://doaj.org/article/fb98ad75841943e3b4fc182c0d41c5af

Metabolic Fingerprinting of Feces from Calves, Subjected to Gram-Negative Bacterial Endotoxin

Autor: Saeid Kamel Oroumieh, Abbas Ali Naserian, Lieven Van Meulebroek, Ellen De Paepe, Reza Valizadeh, Lynn Vanhaecke

Publikováno v: Metabolites, Vol 11, Iss 2, p 108 (2021)

Gram-negative bacteria have a well-known impact on the disease state of neonatal calves and their mortality. This study was the first to implement untargeted metabolomics on calves’ fecal samples to unravel the effect of Gram-negative bacterial end

Externí odkaz: https://doaj.org/article/d9904c832bca457dad9f5e0ff6e9bbba

Differential Impact of rhamnolipids and TWEEN80 on composition and functionality of the gut microbiota in the SHIME system

Autor: Lisa Miclotte, Ellen De Paepe, Qiqiong Li, John Van Camp, Andreja Raikovic, Tom Van de Wiele

Dietary emulsifiers have been shown to affect the composition and function of the gut microbial community, both in vivo and in vitro. Yet, several knowledge gaps remain to be addressed: the impact from a longer timeframe exposure on the gut microbiot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e920e5966de9e0fc9f59ee223ade413c
https://doi.org/10.1101/2021.12.15.472660

Disparities in the gut metabolome of post-operative Hirschsprung's disease patients

Autor: Katrien Van Renterghem, Vera Plekhova, Ellen De Paepe, Myriam Van Winckel, Lieselot Hemeryck, Lynn Vanhaecke

Publikováno v: Scientific Reports
Plekhova, V, De Paepe, E, Van Renterghem, K, Van Winckel, M, Hemeryck, L Y & Vanhaecke, L 2021, ' Disparities in the gut metabolome of post-operative Hirschsprung's disease patients ', Scientific Reports, vol. 11, 16167 . https://doi.org/10.1038/s41598-021-95589-0
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
SCIENTIFIC REPORTS

Hirschsprung's disease (HD) is a congenital structural abnormality of the colon seen in approximately 1 to 5000 live births. Despite surgical correction shortly after presentation, up to 60% of patients will express long-term gastrointestinal complai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a274ec88c446b62dc3a9716d61f8a20
https://doi.org/10.1038/s41598-021-95589-0