Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ella S.M. Ng"'
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Tamoxifen is a key therapeutic option for breast cancer treatment. Understanding its complex metabolism and pharmacokinetics is important for dose optimization. We examined the possibility of utilizing archival formalin-fixed paraffin-embedde
Publikováno v:
Journal of Chromatography B. 931:103-110
An improved quantitative assay was developed and validated for fludarabine in human plasma. Fludarabine and its internal standard, cladribine, were separated on a C18 analytical column after sample purification by strong anion-exchange solid-phase ex
Autor:
Reanne Booker, James A. Russell, Christopher Brown, Jan Storek, Ping Yue, Andrew Daly, N Cox-Kennett, Lynn Savoie, Peter Duggan, T S Williamson, Ella S.M. Ng, C D Griffiths, S B Kangarloo, M A Chaudhry
Publikováno v:
Bone Marrow Transplantation. 49:589-591
Fludarabine metabolite level on day zero does not affect outcomes of hematopoietic cell transplantation in patients with normal renal function
Autor:
Joe M. McCord, Derrice Knight, Daniel Hernandez, David Jourd'heuil, Ella S.M. Ng, Paul Kubes, Mitsukuni Yasui
Publikováno v:
Circulation Research. 94:559-565
In the present study, we investigated whether inhaled nitric oxide (NO) was transported by plasma proteins, such as S -nitroso-albumin (SNO-Alb), in the feline circulation and whether this molecule delivers NO to the periphery under conditions of str
Autor:
Paul Kubes, Ella S.M. Ng
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 81:759-764
Recent work has demonstrated that inhalation of nitric oxide (NO) can impact the peripheral vasculature, suggesting that an NO-stabilizing moiety may exist in vivo. One possibility is the formation of S-nitrosothiols, which extend the half-life of NO
Autor:
Michael J. Hickey, Abdelaziz Amrani, Keith A. Sharkey, Paul Kubes, Ella S.M. Ng, Pere Santamaria, Lori Zbytnuik, Winnie Ho, Elaine Sihota
Publikováno v:
The FASEB Journal. 16:1141-1143
The aim of these experiments was to determine the contribution of leukocyte-derived iNOS to total iNOS expression induced by lipopolysaccharide (LPS). By transferring bone marrow between iNOS+/+ and iNOS-/- mice, we created chimeric mice in which iNO
Nitrosothiol stores in vascular tissue: modulation by ultraviolet light, acetylcholine and ionomycin
Autor:
Zhongjian Cheng, Morley D. Hollenberg, Hong Ding, Ella S.M. Ng, Yanfen Jiang, Yang Li, Chris R. Triggle, Anthie Ellis
Publikováno v:
European journal of pharmacology. 560(2-3)
Our previous studies demonstrated that light-induced vascular relaxation (photorelaxation) was mediated by a tissue source of nitric oxide that was independent of endothelial nitric oxide synthase (eNOS), but sensitive to inhibitors of soluble guanyl
Autor:
Lisa Ceroni, Karen L. Andrews, Morley D. Hollenberg, Ella S.M. Ng, Hong Ding, Malarvannan Pannirselvam, William B. Wiehler, Chris R. Triggle, Yanfen Jiang, Todd J. Anderson, Anthie Ellis, John J. McGuire
Publikováno v:
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 39(6)
In this review we discuss the contribution of NO, prostacyclin and endothelium-derived relaxing factor--endothelium-derived hyperpolarizing factor, or EDHF, to vascular function. We also explore the hypotheses (1): that tissues can store NO as nitros
Autor:
Shahbal B. Kangarloo, Patricia A. Tang, Ella S.M. Ng, Dongsheng Tu, Vivien H.C. Bramwell, Kathleen I. Pritchard, Lois E. Shepherd, Anthony M. Magliocco
Publikováno v:
Journal of Clinical Oncology. 32:1524-1524
1524 Background: The clinical impact of CYP2D6 genetic polymorphisms on tamoxifen (Tam) remains unclear. Active metabolite levels of Tam can be influenced by drug interaction and compliance. This s...
Autor:
Mary Lynn Savoie, Jan Storek, Andrew Daly, Cameron D. Griffiths, Tyler Williamson, Peter Duggan, Reanne Booker, Ping Yue, Ella S.M. Ng, Christopher Brown, James A. Russell, Bill Kangarloo
Publikováno v:
Blood. 122:2116-2116
Background Fludarabine, an immunosuppressive and cytotoxic purine analogue, is a common constituent of conditioning for hematopoietic cell transplantation (HCT). It is a prodrug that is dephosphorylated in plasma to its measurable metabolite, F-ara-A