Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ella P. Dennis"'
Autor:
Kirsty Hodgson, Margarita Orozco-Moreno, Emily Archer Goode, Matthew Fisher, Rebecca Garnham, Richard Beatson, Helen Turner, Karen Livermore, Yuhan Zhou, Laura Wilson, Eline A. Visser, Johan FA. Pijnenborg, Nienke Eerden, Sam J. Moons, Emiel Rossing, Gerald Hysenaj, Rashi Krishna, Ziqian Peng, Kyla Putri Nangkana, Edward N. Schmidt, Adam Duxfield, Ella P. Dennis, Rakesh Heer, Michelle A. Lawson, Matthew Macauley, David J. Elliott, Christian Büll, Emma Scott, Thomas J. Boltje, Richard R. Drake, Ning Wang, Jennifer Munkley
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105163- (2024)
Summary: Background: Bone metastasis is a common consequence of advanced prostate cancer. Bisphosphonates can be used to manage symptoms, but there are currently no curative treatments available. Altered tumour cell glycosylation is a hallmark of can
Externí odkaz:
https://doaj.org/article/afcff439ec0a4487aa2daaa9f610248c
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Cysteine rich with epidermal growth factor (EGF)-like domains 2 (CRELD2) is an endoplasmic reticulum (ER) resident chaperone protein with calcium binding properties. CRELD2 is an ER-stress regulated gene that has been implicated in the patho
Externí odkaz:
https://doaj.org/article/0b65843fcc6946a69ce958af80de19a6
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1496 (2023)
The intracellular retention of mutant cartilage matrix proteins and pathological endoplasmic reticulum (ER) stress disrupts ossification and has been identified as a shared disease mechanism in a range of skeletal dysplasias including short limbed-dw
Externí odkaz:
https://doaj.org/article/d301e0e2774f45558f8f57501113d659
Autor:
Katarzyna A Piróg, Ella P Dennis, Claire L Hartley, Robert M Jackson, Jamie Soul, Jean-Marc Schwartz, John F Bateman, Raymond P Boot-Handford, Michael D Briggs
Publikováno v:
PLoS Genetics, Vol 15, Iss 7, p e1008215 (2019)
The unfolded protein response (UPR) is a conserved cellular response to the accumulation of proteinaceous material in endoplasmic reticulum (ER), active both in health and disease to alleviate cellular stress and improve protein folding. Multiple epi
Externí odkaz:
https://doaj.org/article/01650fe1a5954ca4a1d86bc01e39d7f1
Cysteine rich with epidermal growth factor (EGF)-like domains 2 (CRELD2) is an endoplasmic reticulum (ER) resident chaperone protein with calcium binding properties. CRELD2 is an ER-stress regulated gene that has been implicated in the pathogenesis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6775aaa755ccef3b6080ccb9a8f8ab08
https://doi.org/10.21203/rs.3.rs-1435321/v1
https://doi.org/10.21203/rs.3.rs-1435321/v1
Publikováno v:
Developmental Dynamics. 250:345-359
For the vast majority of the 6000 known rare disease the pathogenic mechanisms are poorly defined and there is little treatment, leading to poor quality of life and high healthcare costs. Genetic skeletal diseases (skeletal dysplasias) are archetypal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6302218182359844261a804b39afca29
https://doi.org/10.1002/dvdy.221
https://doi.org/10.1002/dvdy.221
Autor:
Sarah M. Edwards, Michael D. Briggs, Claire L. Hartley, Raymond P. Boot‐Handford, Dimitra Tsompani, Anna Teti, Katarzyna A. Piróg, Mattia Capulli, Robert M. Jackson, Ella P. Dennis, David Young
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67ed5d1a102a484308de6358d3f8e380
https://doi.org/10.1002/jbmr.4010/v2/response1
https://doi.org/10.1002/jbmr.4010/v2/response1
Autor:
Raymond P. Boot-Handford, Ella P. Dennis, Robert M. Jackson, Katarzyna A. Piróg, Michael D. Briggs, Dimitra Tsompani, Sarah M. Edwards, Anna Teti, Claire L. Hartley, Mattia Capulli, David Young
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchReferences. 35(8)
Cysteine-rich with epidermal growth factor (EGF)-like domains 2 (CRELD2) is an endoplasmic reticulum (ER)-resident chaperone highly activated under ER stress in conditions such as chondrodysplasias; however, its role in healthy skeletal development i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33c2e1a91db541903f247b5c2d90a3b
https://pubmed.ncbi.nlm.nih.gov/32181934
https://pubmed.ncbi.nlm.nih.gov/32181934
Publikováno v:
F1000Research
Cartilage comprises a single cell type, the chondrocyte, embedded in a highly complex extracellular matrix. Disruption to the cartilage growth plate leads to reduced bone growth and results in a clinically diverse group of conditions known as genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a429e4ec3edf1dcc465412105adc18d9
https://doi.org/10.12688/f1000research.22275.1
https://doi.org/10.12688/f1000research.22275.1
Autor:
Katarzyna A, Piróg, Ella P, Dennis, Claire L, Hartley, Robert M, Jackson, Jamie, Soul, Jean-Marc, Schwartz, John F, Bateman, Raymond P, Boot-Handford, Michael D, Briggs
Publikováno v:
PLoS Genetics
The unfolded protein response (UPR) is a conserved cellular response to the accumulation of proteinaceous material in endoplasmic reticulum (ER), active both in health and disease to alleviate cellular stress and improve protein folding. Multiple epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f51f448cdd0fdb02dd06137be355e3b1
https://pubmed.ncbi.nlm.nih.gov/31260448
https://pubmed.ncbi.nlm.nih.gov/31260448