Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ella N. Hoogenboezem"'
Autor:
Ella N. Hoogenboezem, Shrusti S. Patel, Justin H. Lo, Ashley B. Cavnar, Lauren M. Babb, Nora Francini, Eva F. Gbur, Prarthana Patil, Juan M. Colazo, Danielle L. Michell, Violeta M. Sanchez, Joshua T. McCune, Jinqi Ma, Carlisle R. DeJulius, Linus H. Lee, Jonah C. Rosch, Ryan M. Allen, Larry D. Stokes, Jordan L. Hill, Kasey C. Vickers, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The high potential of siRNAs to silence oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, divalent lipid-conjugated siRNAs are optimized for in situ binding to albumin to improve pharmacokinetics
Externí odkaz:
https://doaj.org/article/a8ad79f8d57c45aeac75fe1a848bd947
Autor:
Ella N. Hoogenboezem, Shrusti S. Patel, Ashley B. Cavnar, Justin H. Lo, Lauren M. Babb, Nora Francini, Prarthana Patil, Juan M. Colazo, Danielle L. Michell, Violeta M. Sanchez, Joshua T. McCune, Jinqi Ma, Carlisle R. DeJulius, Linus H. Lee, Jonah C. Rosch, Ryan M. Allen, Larry D. Stokes, Jordan L. Hill, Kasey C. Vickers, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
bioRxiv
The high potential for therapeutic application of siRNAs to silence traditionally undruggable oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, siRNAs were optimized forin situbinding to albumin through C1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed437d3b4e1884a99c1762f14a4e284b
https://doi.org/10.1101/2023.02.14.528574
https://doi.org/10.1101/2023.02.14.528574
Autor:
Shrusti S. Patel, Ella N. Hoogenboezem, Fang Yu, Carlisle R. DeJulius, R. Brock Fletcher, Alex G. Sorets, Fiona K. Cherry, Justin H. Lo, Mariah G. Bezold, Nora Francini, Richard d’Arcy, Jordan E. Brasuell, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
Biomaterials. 297:122098
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1276b7e1e8ea830351a1a71c1114dbd
https://doi.org/10.1016/j.biomaterials.2023.122098
https://doi.org/10.1016/j.biomaterials.2023.122098
Autor:
Shrusti S. Patel, Ella N. Hoogenboezem, Fang Yu, Alex G. Sorets, Fiona K. Cherry, Justin H. Lo, Nora Francini, Richard A. d'Arcy, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
Cancer Research. 83:2706-2706
Triple negative breast cancers (TNBCs) are aggressive malignancies with a high rate of recurrence even after neoadjuvant chemotherapy (NAC) and resection. Nearly 50% of NAC-treated TNBC patients harboring residual disease display mutations in the pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48a889f88ef3773a5e347214b27650fd
https://doi.org/10.1158/1538-7445.am2023-2706
https://doi.org/10.1158/1538-7445.am2023-2706
Publikováno v:
Cell Mol Bioeng
INTRODUCTION: Short interfering RNAs (siRNAs) are potent nucleic acid-based drugs designed to target disease driving genes that may otherwise be undruggable with small molecules. However, therapeutic potential of siRNA in vivo is limited by poor phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5c2998aa18239e6721a34df3f156ed
https://europepmc.org/articles/PMC8938549/
https://europepmc.org/articles/PMC8938549/
Autor:
Evan B. Glass, Allyson R. King, Isom B. Kelly, Alyssa M. Hasty, Prarthana Patil, Todd D. Giorgio, Bryan R. Dollinger, Fang Yu, Sean K. Bedingfield, Rachel E. Miles, Shrusti S. Patel, Meredith A. Jackson, Danielle D. Liu, Ella N. Hoogenboezem, Craig L. Duvall, Matthew A. Cottam
Publikováno v:
Biomaterials
In vivonanocarrier-associated toxicity is a significant and poorly understood hurdle to clinical translation of siRNA nanomedicines. In this work, we demonstrate that platelet activating factor (PAF), an inflammatory lipid mediator, plays a key role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb5040a632bca16268a2cd1c732cd75
https://pubmed.ncbi.nlm.nih.gov/33285438
https://pubmed.ncbi.nlm.nih.gov/33285438
Autor:
Craig L. Duvall, Ella N. Hoogenboezem
Publikováno v:
Advanced drug delivery reviews. 130
Serum albumin, a natural ligand carrier that is highly concentrated and long-circulating in the blood, has shown remarkable promise as a carrier for anti-cancer agents. Albumin is able to prolong the circulation half-life of otherwise rapidly cleared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0898bcf48a63369398dfd5dfccfc061
https://pubmed.ncbi.nlm.nih.gov/30012492
https://pubmed.ncbi.nlm.nih.gov/30012492
Autor:
Christine E. Schmidt, Stacy Porvasnik, Rebecca A. Wachs, Shangjing Xin, Hammad I. Huda, Ella N. Hoogenboezem
Publikováno v:
The spine journal : official journal of the North American Spine Society. 17(3)
Background Context Disc degeneration is the leading cause of low back pain and is often characterized by a loss of disc height, resulting from cleavage of chondroitin sulfate proteoglycans (CSPGs) present in the nucleus pulposus. Intact CSPGs are cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18047409446ab77725b62ea5ae47cf5
https://pubmed.ncbi.nlm.nih.gov/27989725
https://pubmed.ncbi.nlm.nih.gov/27989725