Exposure of Microglia to Interleukin-4 Represses NF-κB-Dependent Transcription of Toll-Like Receptor-Induced Cytokines

Autor: Ella A. Zuiderwijk-Sick, Céline van der Putten, Raissa Timmerman, Jennifer Veth, Erica M. Pasini, Linda van Straalen, Paul van der Valk, Sandra Amor, Jeffrey J. Bajramovic

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Interleukin (IL)-4 is a cytokine that affects both adaptive and innate immune responses. In the central nervous system, microglia express IL-4 receptors and it has been described that IL-4-exposed microglia acquire anti-inflammatory properties. We he

Externí odkaz: https://doaj.org/article/000ca16e7f24436986f08d1b1ba48e40

Transcriptome analysis reveals the contribution of oligodendrocyte and radial glia-derived cues for maintenance of microglia identity

Autor: Raissa Timmerman, Ella A. Zuiderwijk‐Sick, Nynke Oosterhof, Anke E. J. 't Jong, Jennifer Veth, Saskia M. Burm, Tjakko J. van Ham, Jeffrey J. Bajramovic

Publikováno v: Glia, 70(4), 728-747. Wiley
GLIA, 70(4), 728-747. John Wiley & Sons Inc.

Microglia are increasingly being recognized as druggable targets in neurodegenerative disorders, and good in vitro models are crucial to address cell biological questions. Major challenges are to recapitulate the complex microglial morphology and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8c9ebb6fc2c7a0034b330fbd03e7db
https://pubmed.ncbi.nlm.nih.gov/34961968

Transcriptional profiling of macaque microglia reveals an evolutionary preserved gene expression program

Autor: Bart J. L. Eggen, Marissa L. Dubbelaar, Nieske Brouwer, Saskia M. Burm, Jeffrey J. Bajramovic, Ella A. Zuiderwijk-Sick, Sueli Mieko Oba Shinjo, Corien Grit, Suely Kazue Nagahashi Marie, H W G M Boddeke, Susanne M. Kooistra, C Misrielal

Publikováno v: Brain, Behavior, & Immunity-Health, Vol 15, Iss, Pp 100265-(2021)
Brain, Behavior, & Immunity-Health
Brain, behavior, & immunity-health, 15:100265

Microglia are tissue-resident macrophages of the central nervous system (CNS), and important for CNS development and homeostasis. In the adult CNS, microglia monitor environmental changes and react to tissue damage, cellular debris, and pathogens. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd1b45d68f9d5868152339d5cf86b20
https://doi.org/10.1016/j.bbih.2021.100265

TLR-Induced IL-12 and CCL2 Production by Myeloid Cells Is Dependent on Adenosine A

Autor: Céline, van der Putten, Jennifer, Veth, Lejla, Sukurova, Ella A, Zuiderwijk-Sick, Elles, Simonetti, Hans J P M, Koenen, Saskia M, Burm, Johannes M, van Noort, Ad P, IJzerman, Sacha A F T, van Hijum, Dimitri, Diavatopoulos, Jeffrey J, Bajramovic

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 202(8)

TLR-induced signaling potently activates cells of the innate immune system and is subject to regulation at different levels. Inflammatory conditions are associated with increased levels of extracellular adenosine, which can modulate TLR-induced produ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a923c8ffb96fc620df25cd372e1efde
https://pubmed.ncbi.nlm.nih.gov/30804043

ATP-induced IL-1β secretion is selectively impaired in microglia as compared to hematopoietic macrophages

Autor: Saskia Maria, Burm, Ella Alwine, Zuiderwijk-Sick, Paola Massiel, Weert, Jeffrey John, Bajramovic

Publikováno v: Glia. 64(12)

Under stressful conditions nucleotides are released from dying cells into the extracellular space, where they can bind to purinergic P2X and P2Y receptors. High concentrations of extracellular ATP in particular induce P2X7-mediated signaling, which l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db883e3ac24e66df421b7b14c3fa88de
https://pubmed.ncbi.nlm.nih.gov/27641912