Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Elke. Langkopf"'
1
3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: A class of potent DPP-4 inhibitors
Autor: Frank Himmelsbach, Ralf Lotz, Moh Tadayyon, Elke Langkopf, Herbert Nar, Norbert Hauel, Leo Thomas, Matthias Eckhardt, Michael Mark, Brian Guth
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:3158-3162
Systematic variations of the xanthine scaffold in close analogs of development compound BI 1356 led to the class of 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones which provided, after substituent screening, a series of highly potent DPP-4 inhibitors.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b59de9fefdb0ce2e2888c2d4574bfc
https://doi.org/10.1016/j.bmcl.2008.04.075
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2
Synthesis of 2-bromo-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and 3-alkyl-2-bromo-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and their selective elaboration
Autor: Matthias Eckhardt, Norbert Hauel, Elke Langkopf, Frank Himmelsbach
Publikováno v: Tetrahedron Letters. 49:1931-1934
Two synthetic routes to the versatile 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones 2 and 5 have been developed that allow the production of multigram quantities without the need of any chromatographic purification. Broad and selective elaboration of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7335322c41a8553b0ba400157a62082
https://doi.org/10.1016/j.tetlet.2008.01.102
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3
8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes
Autor: Holger Fuchs, Moh Tadayyon, Ralf Lotz, Waldemar Pfrengle, Michael Mark, Peter Sieger, Herbert Nar, Elke Langkopf, Matthias Eckhardt, Frank Himmelsbach, Brian Guth, Leo Thomas
Publikováno v: Journal of Medicinal Chemistry. 50:6450-6453
A new chemical class of potent DPP-4 inhibitors structurally derived from the xanthine scaffold for the treatment of type 2 diabetes has been discovered and evaluated. Systematic structural variations have led to 1 (BI 1356), a highly potent, selecti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18df6e51b88030e28013139bf1167d59
https://doi.org/10.1021/jm701280z
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4
The first metal-catalyzed intramolecular [5+2] cycloadditions of vinylcyclopropanes and alkenes: Scope, stereochemistry, and asymmetric catalysis
Autor: Elke Langkopf, Paul A. Wender, Craig O. Husfeld, Norbert Pleuss, Jennifer A. Love
Publikováno v: Tetrahedron. 54:7203-7220
The first studies of the metal-catalyzed [5+2] cycloadditions of vinylcyclopropanes and alkenes are described. These reactions proceed with exceptional diastereoselectivity and in good to excellent yields. The effect of tether and substituent variati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a458be5cbbf418f1dde050cf4fc5d92
https://doi.org/10.1016/s0040-4020(98)00355-x
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9
ChemInform Abstract: The First Metal-Catalyzed Intramolecular [5 + 2] Cycloadditions of Vinylcyclopropanes and Alkenes: Scope, Stereochemistry, and Asymmetric Catalysis
Autor: Elke Langkopf, Craig O. Husfeld, Jennifer A. Love, Paul A. Wender, Norbert Pleuss
Publikováno v: ChemInform. 29
The first studies of the metal-catalyzed [5+2] cycloadditions of vinylcyclopropanes and alkenes are described. These reactions proceed with exceptional diastereoselectivity and in good to excellent yields. The effect of tether and substituent variati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74e0aa8dd7fceec3306c06c3436eb5b2
https://doi.org/10.1002/chin.199840069
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