Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity

Autor: Sophia Hauck, Paula Zager, Norbert Halfter, Elke Wandel, Marta Torregrossa, Ainur Kakpenova, Sandra Rother, Michelle Ordieres, Susann Räthel, Albrecht Berg, Stephanie Möller, Matthias Schnabelrauch, Jan C. Simon, Vera Hintze, Sandra Franz

Publikováno v: Bioactive Materials, Vol 6, Iss 12, Pp 4342-4359 (2021)

Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds. Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced t

Externí odkaz: https://doaj.org/article/12c3caa613e84af28bc0f2f90badb13e

Overexpression of CD97 in intestinal epithelial cells of transgenic mice attenuates colitis by strengthening adherens junctions.

Autor: Susann Becker, Elke Wandel, Manja Wobus, Rick Schneider, Salah Amasheh, Doreen Sittig, Christiane Kerner, Ronald Naumann, Joerg Hamann, Gabriela Aust

Publikováno v: PLoS ONE, Vol 5, Iss 1, p e8507 (2010)

The adhesion G-protein-coupled receptor CD97 is present in normal colonic enterocytes but overexpressed in colorectal carcinoma. To investigate the function of CD97 in colorectal carcinogenesis, transgenic Tg(villin-CD97) mice overexpressing CD97 in

Externí odkaz: https://doaj.org/article/ccbb47c3eae5439ebd6caa992ffdf058

Dermal Fibroblasts Promote Alternative Macrophage Activation Improving Impaired Wound Healing

Autor: Mike Grünwedel, Sandra Franz, Elke Wandel, Jan C. Simon, Inka Forstreuter, Susann Saupe, Rubén A. Ferrer, Nadine Lohmann, Anja Saalbach

Publikováno v: Journal of Investigative Dermatology. 137:941-950

Tight control of inflammation is required for tissue repair and wound healing and depends on alternative polarization of macrophages as checkpoint for inflammatory resolution. Its perturbations lead to impaired regeneration. Administration of cells/c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5090824de3053c17ee87cf8ca5b07b3d
https://doi.org/10.1016/j.jid.2016.11.035

Sulfated hyaluronan attenuates inflammatory signaling pathways in macrophages involving induction of antioxidants

Autor: Sandra Franz, Florent Jouy, Matthias Schnabelrauch, Nadine Lohmann, Gloria Ruiz-Gómez, Martin von Bergen, M. Teresa Pisabarro, Stefan Kalkhof, Stephanie Möller, Annette G. Beck-Sickinger, Elke Wandel, Jan C. Simon

Publikováno v: Jouy, F, Lohmann, N, Wandel, E, Ruiz-Gómez, G, Pisabarro, M T, Beck-Sickinger, A G, Schnabelrauch, M, Möller, S, Simon, J C, Kalkhof, S, von Bergen, M & Franz, S 2017, ' Sulfated hyaluronan attenuates inflammatory signaling pathways in macrophages involving induction of antioxidants ', Proteomics, vol. 17, no. 10, 1700082 . https://doi.org/10.1002/pmic.201700082

It is well recognized that high molecular weight hyaluronan (H-HA) exerts potent anti-inflammatory effects while its fragmentation into low molecular weight HA (L-HA) is discussed to promote inflammation. Chemical modification of HA with sulfate grou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5133ba50a656dbddea031a2873109958
https://vbn.aau.dk/da/publications/75f705f3-cd7e-4333-b394-9f70628f483d

Anti-Inflammatory Action of Keratinocyte-Derived Vaspin: Relevance for the Pathogenesis of Psoriasis

Autor: Anja, Saalbach, Jenny, Tremel, Diana, Herbert, Katharina, Schwede, Elke, Wandel, Christine, Schirmer, Ulf, Anderegg, Annette G, Beck-Sickinger, John T, Heiker, Stephan, Schultz, Thomas, Magin, Jan C, Simon

Publikováno v: The American journal of pathology. 186(3)

Impaired cross talk between keratinocytes (KCs) and immune cells is believed to contribute to the pathogenesis of chronic inflammatory skin diseases, such as psoriasis. We have previously identified KCs as a rich source of the serpin protease inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b0fdcb927e81b1ccf8b0db13fbda6680
https://pubmed.ncbi.nlm.nih.gov/26783881