Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elke Vermassen"'
Autor:
Tine Van Bergen, Elke Vermassen, Jean H.M. Feyen, Jin-Ping Li, Israel Vlodavsky, Isabelle Etienne, Juan Jia, Alan W. Stitt
Publikováno v:
Current Eye Research. 46:1166-1170
Pentosan polysulfate sodium (PPS; Elmiron) is a FDA-approved heparanase inhibitor for the treatment of bladder pain and interstitial cystitis. The chronic use of PPS has been associated with a novel pigmentary maculopathy, associated with discrete vi
Autor:
Lieve Moons, Jean H.M. Feyen, Karis Little, Lies De Groef, Tine Van Bergen, Elke Vermassen, Tjing-Tjing Hu, Alan W. Stitt
Publikováno v:
Investigative Ophthalmology & Visual Science
Van Bergen, T, Hu, T-T, Little, K, De Groef, L, Moons, L, Stitt, A W, Vermassen, E & Feyen, J H M 2021, ' Targeting Plasma Kallikrein With a Novel Bicyclic Peptide Inhibitor (THR-149) Reduces Retinal Thickening in a Diabetic Rat Model ', Investigative ophthalmology & visual science, vol. 62, no. 13, 18 . https://doi.org/10.1167/iovs.62.13.18
Van Bergen, T, Hu, T-T, Little, K, De Groef, L, Moons, L, Stitt, A W, Vermassen, E & Feyen, J H M 2021, ' Targeting Plasma Kallikrein With a Novel Bicyclic Peptide Inhibitor (THR-149) Reduces Retinal Thickening in a Diabetic Rat Model ', Investigative ophthalmology & visual science, vol. 62, no. 13, 18 . https://doi.org/10.1167/iovs.62.13.18
PURPOSE: To investigate the effect of plasma kallikrein (PKal)-inhibition by THR-149 on preventing key pathologies associated with diabetic macular edema (DME) in a rat model. METHODS: Following streptozotocin-induced diabetes, THR-149 or its vehicle
Publikováno v:
Vanhove, M, Wagner, J-M, Noppen, B, Jonckx, B, Vermassen, E & Stitt, A W 2021, ' Systemic exposure following intravitreal administration of therapeutic agents: an integrated pharmacokinetic approach. 2. THR-687 ', Journal of Pharmacokinetics and Pharmacodynamics . https://doi.org/10.1007/s10928-021-09774-9
Journal of Pharmacokinetics and Pharmacodynamics
Journal of Pharmacokinetics and Pharmacodynamics
Intravitreal (IVT) injection remains the preferred administration route of pharmacological agents intended for the treatment of back of the eye diseases such as diabetic macular edema (DME) and neovascular age-related macular degeneration (nvAMD). Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bd9d4645464232f62949578a1152af
https://pure.qub.ac.uk/en/publications/systemic-exposure-following-intravitreal-administration-of-therapeutic-agents-an-integrated-pharmacokinetic-approach-2-thr687(26c50aea-d0d5-44c4-a18a-55c8f2ca28b4).html
https://pure.qub.ac.uk/en/publications/systemic-exposure-following-intravitreal-administration-of-therapeutic-agents-an-integrated-pharmacokinetic-approach-2-thr687(26c50aea-d0d5-44c4-a18a-55c8f2ca28b4).html
Publikováno v:
Acta Ophthalmologica. 97
Autor:
Tine Van Bergen, Elke Vermassen, Jean H.M. Feyen, Tjing Tjing Hu, Isabelle Etienne, Alan W. Stitt, Karen Beets, Inge Van Hove
Publikováno v:
Van Hove, I, Hu, T-T, Beets, K, Van Bergen, T, Etienne, I, Stitt, A W, Vermassen, E & Feyen, J H M 2021, ' Targeting RGD-binding integrins as an integrative therapy for diabetic retinopathy and neovascular age-related macular degeneration ', Progress in retinal and eye research . https://doi.org/10.1016/j.preteyeres.2021.100966
Integrins are a class of transmembrane receptors that are involved in a wide range of biological functions. Dysregulation of integrins has been implicated in many pathological processes and consequently, they are attractive therapeutic targets. In th
Autor:
Inge Van Hove, Michaël Porcu, Jean H.M. Feyen, Tine Van Bergen, Elke Vermassen, Marc Vanhove, Tjing-Tjing Hu, Philippe Barbeaux, Bart Jonckx
Publikováno v:
Experimental eye research. 180
Integrins are associated with various eye diseases such as diabetic retinopathy (DR) and wet age-related macular degeneration (AMD) and implicated in main pathologic disease hallmarks like neovascularization, inflammation, fibrosis and vascular leaka
Autor:
Tjing-Tjing Hu, Catherine Stace, Philippe Barbeaux, Helen Harrison, Gavin Bennett, Tine Van Bergen, Katerine Van Rietschoten, Daniel Teufel, Elke Vermassen, Jean H.M. Feyen, Silvia Pavan, Marc Vanhove, François Le Floch
Publikováno v:
Journal of medicinal chemistry. 61(7)
Plasma kallikrein, a member of the kallikrein-kinin system, catalyzes the release of the bioactive peptide bradykinin, which induces inflammation, vasodilation, vessel permeability, and pain. Preclinical evidence implicates the activity of plasma kal
Publikováno v:
Acta Ophthalmologica. 95
Purpose Pathologic neovascularization and vessel leakage are key drivers for vision loss in several back-of-the-eye diseases, such as diabetic retinopathy and age-related macular degeneration. In the eye, integrin receptors play an important role in
Autor:
Jan B. Parys, Elke Vermassen, Veerle Vanderheyden, Humbert De Smedt, Geert Callewaert, Nael Nadif Kasri, Rafael A. Fissore, Ludwig Missiaen
Publikováno v:
Biochemical and Biophysical Research Communications. 319:888-893
The various inositol 1,4,5-trisphosphate receptor (IP(3)R) isoforms are potential substrates for several protein kinases. We compared the in vitro phosphorylation of purified IP(3)R1 and IP(3)R3 by the catalytic subunit of protein kinase C (PKC). Pho
Autor:
Ludwig Missiaen, Geert Callewaert, Humbert De Smedt, Wim Annaert, Elke Vermassen, Kristel Van Acker, Jan B. Parys, Bernard Himpens
Publikováno v:
Journal of Cell Science. 116:1269-1277
In A7r5 vascular smooth muscle cells, the two expressed inositol 1,4,5-trisphosphate receptor (IP(3)R) isoforms were differentially localized. IP(3)R1 was predominantly localized in the perinuclear region, whereas IP(3)R3 was homogeneously distribute