Targeting nNOS ameliorates the severe neuropathic pain due to chronic pancreatitisResearch in context

Autor: Ihsan Ekin Demir, Tobias Heinrich, Dominique G. Carty, Ömer Cemil Saricaoglu, Sarah Klauss, Steffen Teller, Timo Kehl, Carmen Mota Reyes, Elke Tieftrunk, Maria Lazarou, Dorukhan H. Bahceci, Betül Gökcek, Bahar E. Ucurum, Matthias Maak, Kalliope N. Diakopoulos, Marina Lesina, Michael Schemann, Mert Erkan, Achim Krüger, Hana Algül, Helmut Friess, Güralp O. Ceyhan

Publikováno v: EBioMedicine, Vol 46, Iss , Pp 431-443 (2019)

Background: Pain due to pancreatic cancer/PCa or chronic pancreatitis/CP, is notoriously resistant to the strongest pain medications. Here, we aimed at deciphering the specific molecular mediators of pain at surgical-stage pancreatic disease and to d

Externí odkaz: https://doaj.org/article/e5b83526ca9647e8bb16e16a99287a55

Targeting nNOS ameliorates the severe neuropathic pain due to chronic pancreatitis

Autor: Betül Gökcek, Güralp O. Ceyhan, Mert Erkan, Matthias Maak, Kalliope N. Diakopoulos, Michael Schemann, Helmut Friess, Achim Krüger, Sarah Klauss, Bahar E. Ucurum, Steffen Teller, Ihsan Ekin Demir, Elke Tieftrunk, Dorukhan H. Bahceci, Timo Kehl, Carmen Mota Reyes, Dominique G. Carty, Hana Algül, Ömer Cemil Saricaoglu, Tobias Heinrich, Maria Lazarou, Marina Lesina

Publikováno v: EBioMedicine

Background: pain due to pancreatic cancer/PCa or chronic pancreatitis/CP, is notoriously resistant to the strongest pain medications. Here, we aimed at deciphering the specific molecular mediators of pain at surgical-stage pancreatic disease and to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a845f6586d7d83ed84a303602058080
https://doi.org/10.1016/j.ebiom.2019.07.055

Prognosis of sporadic resected small (≤2 cm) nonfunctional pancreatic neuroendocrine tumors – a multi-institutional study

Autor: Ville Sallinen, Stuart Robinson, Oskar Franklin, Francesca Muffatti, Bertrand Dousset, Shamil Galeev, Anne Antila, Dominik Wiese, Zahar Kovalenko, Alain Sauvanet, Falconi Massimo, Philippe Ruszniewski, G.O. Ceyhan, Nicolas Regenet, Detlef K. Bartsch, Tessa T. Y. Le Large, Francesco Panzuto, Stefano Partelli, Bjørn Edwin, Sven-Petter Haugvik, Elke Tieftrunk, Emma Martínez-Moneo, Sébastien Gaujoux

Publikováno v: HPB, 20(3), 251-259. John Wiley and Sons Inc.
Sallinen, V J, Le Large, T Y S, Tieftrunk, E, Galeev, S, Kovalenko, Z, Haugvik, S P, Antila, A, Franklin, O, Martinez-Moneo, E, Robinson, S M, Panzuto, F, Regenet, N, Muffatti, F, Partelli, S, Wiese, D, Ruszniewski, P, Dousset, B, Edwin, B, Bartsch, D K, Sauvanet, A, Massimo, F, Ceyhan, G O & Gaujoux, S 2018, ' Prognosis of sporadic resected small (≤2 cm) nonfunctional pancreatic neuroendocrine tumors-a multi-institutional study ', HPB, vol. 20, no. 3, pp. 251-259 . https://doi.org/10.1016/j.hpb.2017.08.034
HPB: The official journal of the International Hepato Pancreato Biliary Association, 20(3), 216-221. John Wiley and Sons Inc.

Background: Malignant potential of small (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b976b1676ca8cd3ee3a06b0093e12c04
https://doi.org/10.1016/j.hpb.2017.08.034

Pancreatic stump closure techniques and pancreatic fistula formation after distal pancreatectomy: Meta-analysis and single-center experience

Autor: Lenika Calavrezos, Güralp O. Ceyhan, Stephan Schorn, Elke Tieftrunk, Ihsan Ekin Demir, Mine Sargut, Helmut Friess, Rebekka Schirren, Florian Scheufele

Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0197553 (2018)

Background Pancreatic fistula/PF is the most frequent and feared complication after distal pancreatectomy/DP. However, the safest technique of pancreatic stump closure remains an ongoing debate. Here, we aimed to compare the safety of different pancr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7657e446b874349264d8d24b8fcac9
https://mediatum.ub.tum.de/doc/1517499/document.pdf

Parasympathomimetic agents inhibit pancreatic cancer growth by suppression of the p44/42 MAPK signalling pathway and increase overall survival

Autor: Elke Tieftrunk, IE Demir, Güralp O. Ceyhan, Paulo L. Pfitzinger, Helmut Friess, Kun Wang

Publikováno v: 72. Jahrestagung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten mit Sektion Endoskopie – 11. Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie gemeinsam mit den Arbeitsgemeinschaften der DGAV.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::578d604a55af2fe17e02e6562205997b
https://doi.org/10.1055/s-0037-1605122