Common Histological Features Suggesting Enchondral Ossification Pathways in Calciphylaxis of Various Origins: A Study of Human Subcutaneous Tissue Biopsies

Autor: Simon Aberger, Barbara Findenig, Jane Beil, Nicole Aichinger, Josef Koller, Cees Vermeer, Leon Schurgers, Elke Theuwissen, Elena Moré, Michael Franzen, Cornelia Kronberger, Hermann Salmhofer

Publikováno v: Acta Dermato-Venereologica, Vol 103 (2023)

Calciphylaxis is a rare, yet underdiagnosed condition causing high mortality in patients with severe renal and cardiovascular disease. Since knowledge of the pathophysiology of calciphylaxis is limited, a differential analysis of histological alterat

Externí odkaz: https://doaj.org/article/97eddbc9689640ec9a808e657c5aa246

Desphospho-uncarboxylated matrix Gla-protein is associated with mortality risk in patients with chronic stable vascular disease

Autor: Jan Filipovský, Jan Bruthans, Renata Cifkova, Cees Vermeer, Otto Mayer, Elke Theuwissen, Lenka Černá, Jiří Vaněk, Katarína Timoracká, Peter Wohlfahrt, Jitka Seidlerová

Publikováno v: Atherosclerosis, 235(1), 162-168. Elsevier Ireland Ltd

Background: Vitamin K is the essential co-factor for activation of matrix Gla-protein (MGP), the natural inhibitor of tissue calcification. Biologically inactive, desphospho-uncarboxylated MGP (dp-ucMGP) is a marker of vascular vitamin K status and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11bf6a696c427614864bdb317c2ea126
https://cris.maastrichtuniversity.nl/en/publications/972a43f6-19f3-4b7e-873a-4f2673842029

Oxidised plant sterols as well as oxycholesterol increase the proportion of severe atherosclerotic lesions in female LDL receptor+/ - mice

Autor: Marion J.J. Gijbels, Ronald P. Mensink, Constanze Husche, Elke Theuwissen, Mike L. J. Jeurissen, Jogchum Plat, Ronit Shiri-Sverdlov, Dieter Lütjohann, Ingeborg van der Made

Publikováno v: British journal of nutrition, 111(1), 64-70. Cambridge University Press
British Journal of Nutrition, 111(1), 64-70. Cambridge University Press

Oxysterols (oxidised cholesterol) may play a role in the pathogenesis of CVD. Similar to cholesterol, plant sterols are susceptible to oxidation. However, less is known about the potential atherogenicity of oxidised plant sterols (oxyphytosterols). I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3944619027f3e3d975cbdb771d5d64
https://doi.org/10.1017/s0007114513002018

Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight

Autor: Cees Vermeer, Marjo H. J. Knapen, Leon J. Schurgers, Elke Theuwissen, Martin J. Shearer, Paul Newman

Publikováno v: British Journal of Nutrition, 108(6), 1017-1024. Cambridge University Press

Osteocalcin (OC) is a vitamin K-dependent protein found in bone and in circulation. High serum γ-carboxylated OC reflects a high, and high uncarboxylated OC (ucOC) reflects a low vitamin K status. A revolutionary hypothesis is that ucOC acts as a ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e652e3a8c032c29da6b67a840759a390
https://doi.org/10.1017/s000711451100626x

The Role of Vitamin K in Soft-Tissue Calcification

Autor: Egbert F. Smit, Cees Vermeer, Elke Theuwissen

Publikováno v: Advances in Nutrition. 3:166-173

Seventeen vitamin K–dependent proteins have been identified to date of which several are involved in regulating soft-tissue calcification. Osteocalcin, matrix Gla protein (MGP), and possibly Gla-rich protein are all inhibitors of soft-tissue calcif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153d236217a76b42a7a9039361535c6c
https://doi.org/10.3945/an.111.001628