Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elke Stirnal"'
Autor:
Tobias Lieblein, Rene Zangl, Janosch Martin, Jan Hoffmann, Marie J Hutchison, Tina Stark, Elke Stirnal, Thomas Schrader, Harald Schwalbe, Nina Morgner
Publikováno v:
eLife, Vol 9 (2020)
The formation of oligomers of the amyloid-β peptide plays a key role in the onset of Alzheimer's disease. We describe herein the investigation of disease-relevant small amyloid-β oligomers by mass spectrometry and ion mobility spectrometry, reveali
Externí odkaz:
https://doaj.org/article/ba34516caffd466fb9295cff7f883d7f
Autor:
Alexey Sudakov, Bozana Knezic, Martin Hengesbach, Boris Fürtig, Elke Stirnal, Harald Schwalbe
Publikováno v:
Chemistry – A European Journal. 29
More than 170 post-transcriptional modifications of RNAs have currently been identified. Detailed biophysical investigations of these modifications have been limited since large RNAs containing these post-transcriptional modifications are difficult t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5261c50f8a48ed48ea6a941ea91944
https://doi.org/10.1002/chem.202203368
https://doi.org/10.1002/chem.202203368
Autor:
Marie‐Theres Hutchison, Giovanni Bellomo, Alexey Cherepanov, Elke Stirnal, Boris Fürtig, Christian Richter, Verena Linhard, Elina Gurewitsch, Moreno Lelli, Nina Morgner, Thomas Schrader, Harald Schwalbe
The aggregation of amyloid-β 42 (Aβ42) is directly related to the pathogenesis of Alzheimer's disease. Here, we have investigated the early stages of the aggregation process, during which most of the cytotoxic species are formed. Aβ42 aggregation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc07502196a1e5d96391b93445c6a00
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85149073097
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85149073097
Autor:
Elke Stirnal, Harald Schwalbe, Isam Elamri, Santosh Lakshmi Gande, Chahinez Abdellaoui, Jasleen Kaur Bains, Katharina F. Hohmann, Josef Wachtveitl
Publikováno v:
Journal of the American Chemical Society. 143:10596-10603
Photocleavable protecting groups (PPGs) play a pivotal role in numerous studies. They enable controlled release of small effector molecules to induce biochemical function. The number of PPGs attached to a variety of effector molecules has grown rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cae3a34983d03b4c49e00f68389dc5
https://doi.org/10.1021/jacs.1c02817
https://doi.org/10.1021/jacs.1c02817
Autor:
Klara R. Mertinkus, J. Tassilo Grün, Nadide Altincekic, Jasleen Kaur Bains, Betül Ceylan, Jan-Peter Ferner, Lucio Frydman, Boris Fürtig, Martin Hengesbach, Katharina F. Hohmann, Daniel Hymon, Jihyun Kim, Božana Knezic, Mihajlo Novakovic, Andreas Oxenfarth, Stephen A. Peter, Nusrat S. Qureshi, Christian Richter, Tali Scherf, Andreas Schlundt, Robbin Schnieders, Harald Schwalbe, Elke Stirnal, Alexey Sudakov, Jennifer Vögele, Anna Wacker, Julia E. Weigand, Julia Wirmer-Bartoschek, Maria A. Wirtz Martin, Jens Wöhnert
Publikováno v:
Biomolecular NMR Assignments, 16
The ongoing pandemic of the respiratory disease COVID-19 is caused by the SARS-CoV-2 (SCoV2) virus. SCoV2 is a member of the Betacoronavirus genus. The 30 kb positive sense, single stranded RNA genome of SCoV2 features 5'- and 3'-genomic ends that ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f387aa7cf6d5f0b5a6907a6bb95fa8
https://hdl.handle.net/20.500.11850/534661
https://hdl.handle.net/20.500.11850/534661
Autor:
Jennifer Vögele, Jasleen Kaur Bains, Sophie Marianne Korn, Tom Landgraf, Hendrik R. A. Jonker, Daniel Hymon, Robbin Schnieders, Daniel Mathieu, Sabrina Toews, Nadide Altincekic, Bozana Knezic, Katharina F. Hohmann, J Tassilo Grün, Julia Wirmer-Bartoschek, Frank Löhr, Elke Duchardt-Ferner, Anna Wacker, Kerstin Witt, Dennis J. Pyper, Alexey Sudakov, Jens Wöhnert, Boris Fürtig, Julia E. Weigand, Stephen A. Peter, Betül Ceylan, Harald Schwalbe, Oliver Binas, Martin Hengesbach, Elke Stirnal, Andreas Schlundt, Nusrat S. Qureshi, Christian Richter, Jan Ferner
Publikováno v:
Biomolecular Nmr Assignments
The stem-loop (SL1) is the 5'-terminal structural element within the single-stranded SARS-CoV-2 RNA genome. It is formed by nucleotides 7–33 and consists of two short helical segments interrupted by an asymmetric internal loop. This architecture is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca8d91e354fdc03948fa1f0e0e6af4a
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63569
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63569
Autor:
Harald Schwalbe, Jens Wöhnert, Boris Fürtig, Stephen A. Peter, Dennis J. Pyper, Alexey Sudakov, Frank Löhr, Betül Ceylan, Elke Duchardt-Ferner, Anna Wacker, Andreas Schlundt, Martin Hengesbach, Nusrat S. Qureshi, Bozana Knezic, Katharina F. Hohmann, Julia E. Weigand, Jennifer Vögele, Elke Stirnal, Jasleen Kaur Bains, J Tassilo Grün, Nadide Altincekic, Daniel Hymon, Julia Wirmer-Bartoschek, Jan Ferner, Christian Richter
Publikováno v:
Biomolecular Nmr Assignments
The SARS-CoV-2 virus is the cause of the respiratory disease COVID-19. As of today, therapeutic interventions in severe COVID-19 cases are still not available as no effective therapeutics have been developed so far. Despite the ongoing development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e453ee3ed308fffea71c1065f826a81
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63659
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63659
Autor:
Anna Wacker, Julia E Weigand, Sabine R Akabayov, Nadide Altincekic, Jasleen Kaur Bains, Elnaz Banijamali, Oliver Binas, Jesus Castillo-Martinez, Erhan Cetiner, Betül Ceylan, Liang-Yuan Chiu, Jesse Davila-Calderon, Karthikeyan Dhamotharan, Elke Duchardt-Ferner, Jan Ferner, Lucio Frydman, Boris Fürtig, José Gallego, J Tassilo Grün, Carolin Hacker, Christina Haddad, Martin Hähnke, Martin Hengesbach, Fabian Hiller, Katharina F Hohmann, Daniel Hymon, Vanessa de Jesus, Henry Jonker, Heiko Keller, Bozana Knezic, Tom Landgraf, Frank Löhr, Le Luo, Klara R Mertinkus, Christina Muhs, Mihajlo Novakovic, Andreas Oxenfarth, Martina Palomino-Schätzlein, Katja Petzold, Stephen A Peter, Dennis J Pyper, Nusrat S Qureshi, Magdalena Riad, Christian Richter, Krishna Saxena, Tatjana Schamber, Tali Scherf, Judith Schlagnitweit, Andreas Schlundt, Robbin Schnieders, Harald Schwalbe, Alvaro Simba-Lahuasi, Sridhar Sreeramulu, Elke Stirnal, Alexey Sudakov, Jan-Niklas Tants, Blanton S Tolbert, Jennifer Vögele, Lena Weiß, Julia Wirmer-Bartoschek, Maria A Wirtz Martin, Jens Wöhnert, Heidi Zetzsche
Publikováno v:
Nucleic Acids Research
The current pandemic situation caused by the Betacoronavirus SARS-CoV-2 (SCoV2) highlights the need for coordinated research to combat COVID-19. A particularly important aspect is the development of medication. In addition to viral proteins, structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ad3a3468b5df3796b23f6db66b8ffd
https://doi.org/10.1093/nar/gkab568
https://doi.org/10.1093/nar/gkab568
Autor:
Tatjana Schamber, Kamal Azzaoui, Nusrat S. Qureshi, Boris Fürtig, Oliver Binas, Jason N Martins, Marcel J. J. Blommers, Daniel Hymon, Alix Tröster, Jasleen Kaur Bains, Christian Richter, Harald Schwalbe, Elke Stirnal, Andreas Oxenfarth, Julia Wirmer-Bartoschek, Hannes Berg, Anna Wacker, Robbin Schnieders, Tom Landgraf, Vanessa de Jesus, Santosh Lakshmi Gande, Sridhar Sreeramulu, Thomas Biedenbänder, Maria Alexandra Wirtz Martin, Albrecht Eduard Völklein, Anna Niesteruk
Publikováno v:
ChemBioChem
Chembiochem
Chembiochem
We report here on the nuclear magnetic resonance (NMR) 19 F screening of 14 RNA targets with different secondary and tertiary structure to systematically assess druggability of RNAs. Our RNA targets include representative bacterial riboswitches that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57aa4c3116edf518bcf60528cde01fe5
Autor:
S. Th. Sigurdsson, Christina Helmling, Kai A. Schnorr, Dnyaneshwar B. Gophane, Dominic Barthelmes, Erhan Can Cetiner, Boris Fürtig, Elke Stirnal, Markus Gränz, K Pasemann, Nusrat S. Qureshi, Anna Wacker, H R A Jonker, Harald Schwalbe
Publikováno v:
Journal of Biomolecular NMR. 68:53-63
Paramagnetic relaxation enhancement (PRE) is a versatile tool for NMR spectroscopic structural and kinetic studies in biological macromolecules. Here, we compare the quality of PRE data derived from two spin labels with markedly different dynamic pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73991bae917c13d8c103b208c71960f0
https://doi.org/10.1007/s10858-017-0114-9
https://doi.org/10.1007/s10858-017-0114-9