Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Elke Stahl"'
Autor:
Elke Stahl
Publikováno v:
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 60:836–840
The upcoming Regulation EU 536/2014 for clinical trials of medicinal products for human use requires multinational cooperation in the assessment of clinical trial applications by the member states concerned as well as one single decision per member s
Autor:
Walter Janssens, Jan Willem van der Laan, Elke Stahl, Joseph T. Brady, Jeroen Bos, Charles Benson, Ulla Wändel-Liminga, Beatriz Silva-Lima, Solange Corriol-Rohou, Roy Forster, Sarah Robertson, Andreas Hartmann, Salah-Dine Chibout, Raleigh E. Malik, Peter Pertel
Publikováno v:
Therapeutic innovationregulatory science. 54(2)
The EU is a member of the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH), and therefore adopts the ICH Guidelines, including the ICH M3 Guideline on Nonclinical Safety Studies. Following the
Autor:
Elke, Stahl
Publikováno v:
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. 60(8)
The upcoming Regulation EU 536/2014 for clinical trials of medicinal products for human use requires multinational cooperation in the assessment of clinical trial applications by the member states concerned as well as one single decision per member s
Autor:
Jan Willem van der Laan, Charles T. Benson, Walter Janssens, Jeroen Bos, Elke Stahl, Joseph T. Brady, Ulla Wändel-Liminga, Solange Corriol-Rohou, Roy Forster, Andreas Hartmann, Peter Einar Pertel, Sarah M. Robertson, Beatriz Silva-Lima, Raleigh E. Malik, Salah-Dine Chibout
Publikováno v:
Therapeutic Innovation & Regulatory Science. :216847901984351
Publikováno v:
The New England journal of medicine. 374(16)
To the Editor: We agree with Swedberg et al.,1 whose Sounding Board article is now published in the Journal, regarding the role and responsibilities of the data monitoring committee. We also agree that the data monitoring committee should be allowed
Autor:
Torsten Minuth, Heiner Apeler, Matthias Schramm, Klaus Dembowsky, Elke Stahl, Johannes-Peter Stasch, Henning Schröder, Wolfram Steinke, Frank Wunder, Peter Schmidt, Elisabeth Perzborn, Werner Schroeder, Cristina Alonso-Alija, Michael Haerter, Markus Heil, Ulrich Pleiss
Publikováno v:
British Journal of Pharmacology. 136:773-783
1. Soluble guanylyl cyclase (sGC) is the only proven receptor for the ubiquitous biological messenger nitric oxide (NO) and is intimately involved in many signal transduction pathways, most notably in regulating vascular tone and platelet function. s
Publikováno v:
British Journal of Pharmacology. 135:344-355
BAY 41-8543 is a novel non-NO-based stimulator of sGC. This study investigates the acute effects of BAY 41-8543 on haemodynamics in anaesthetized rats and dogs, its long-term effects in conscious hypertension rat models and its antiplatelet effects.
Autor:
Wolfram Steinke, Heiner Apeler, Klaus Dembowsky, Henning Schröder, Matthias Schramm, Eva Maria Becker, Johannes-Peter Stasch, Werner Schroeder, Elisabeth Perzborn, Cristina Alonso-Alija, Achim Feurer, Torsten Minuth, Elke Stahl, Rupert Gerzer, Alexander Straub, Ulrich Pleiß
Publikováno v:
Nature. 410:212-215
Nitric oxide (NO) is a widespread, potent, biological mediator that has many physiological and pathophysiological roles. Research in the field of NO appears to have followed a straightforward path, and the findings have been progressive: NO and cycli
Publikováno v:
Clinical Pharmacology & Therapeutics. 57:636-644
Ibuprofen is an over-the-counter nonsteroidal anti-inflammatory drug with a low incidence of severe adverse reactions. It is metabolized by oxidation to carboxyibuprofen and hydroxyibuprofen and by conjugation to an acyl glucuronide. In vitro studies
Autor:
Ernst Mutschler, Dorit Henke, Hildegard Spahn-Langguth, U. Baumgartner, Elke Stahl, Jürgen Schölmerich
Publikováno v:
Chirality. 5:1-7
As an experimental model for reduced liver function rats with surgical portacaval shunts (pcs) may be used. Carvedilol, a nonselective β-adrenoceptor antagonist with vasodilating activity, is extensively metabolised by phase I as well as phase II pa