Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Elke Schäffeler"'
Autor:
André Strohmeyer, Simone Harsch, Satoko Hirobe-Jahn, Elke Schäffeler, Dominique Richter, Silke Schimmel, Oliver Müller, Matthias Schwab, Eduard F. Stange, Olga Renner, Wolfgang Kratzer
Publikováno v:
Journal of Proteomics. 75:3386-3399
In recent years MALDI-TOF MS gained importance for high-throughput DNA analysis. In the present study this technique was used for the pathogenetic analysis of gallstone disease. The intestinal apical sodium-dependent bile acid transporter (ASBT) show
Autor:
Claudia Marx, Bernd A. Kaskas, Elke Schäffeler, Christoph Behrens, Thomas Lang, Christine Fischer, Matthias Schwab, Michael Gregor, Michel Eichelbaum, Ulrich M. Zanger
Publikováno v:
Pharmacogenetics. 12:429-436
The efficacy of the immunosuppressants azathioprine and 6-mercaptopurine has been well established in the therapy of inflammatory bowel diseases (IBD). However, its use has been complicated by a high incidence of serious adverse drug reactions such a
Autor:
M. Siegsmund, Ulrich Brinkmann, Michel Eichelbaum, Gregor Weirich, Oliver Burk, Hiltrud Brauch, Reinhold Kerb, Sven Hoffmeyer, Elke Schäffeler, Peter Alken, Jochen Decker, Peter Fritz, Matthias Schwab, Uwe Rothenpieler
Publikováno v:
Journal of the American Society of Nephrology. 13:1847-1854
Except for hereditary disease, genetic factors that contribute to the development of renal epithelial tumors are unknown. There is a possibility that the MDR1 encoded plasma membrane transporter P-glycoprotein (PGP) influences the risk of development
Autor:
Janina Metzger, Karin Müller, Michal Droppa, Athanasios Karathanos, Stefan Winter, Tobias Geisler, Elke Schäffeler, Dominik Rath, Elli Tavlaki, Matthias Schwab, Fabian Stimpfle, Meinrad Gawaz
Publikováno v:
Thrombosis research. 134(1)
Aims Only limited data exist about the role of point of care CYP2C19 testing in the acute setting in the early phase of acute coronary syndromes (ACS). Therefore, the present study was designed to investigate the impact of CYP2C19 loss-of–function
Autor:
Matthias Schwab, Elke Schäffeler, Eichelbaum Michel, Monika Hitzl, Heiko van der Kuip, Siegfried Drescher, Martin F. Fromm, Joachim Fischer
Publikováno v:
Pharmacogenetics. 11:293-298
P-glycoprotein (PGP) is a membrane protein which determines drug disposition in humans (e.g. digoxin). It is also expressed in various leukocyte lineages with highest expression in CD56+ natural killer cells. Recently, a polymorphism in exon 26 (C343
Autor:
Andreas, Tromm, Ivan, Bunganič, Eva, Tomsová, Zsolt, Tulassay, Milan, Lukáš, Jan, Kykal, Marian, Bátovský, Bohumil, Fixa, Libor, Gabalec, Rifaat, Safadi, Heinz-Jochen, Kramm, István, Altorjay, Hanns, Löhr, Ioannis, Koutroubakis, Simon, Bar-Meir, Davor, Stimac, Elke, Schäffeler, Christoph, Glasmacher, Karin, Dilger, Ralf, Mohrbacher, Roland, Greinwald, Gerhard, Rogler
Background & Aims Comparative data on budesonide vs mesalamine for the treatment of mild-to-moderately active Crohn's disease (CD) are sparse. We assessed the efficacy and safety of each therapy in patients with mildly to moderately active CD. Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727bbf0f77778dfbd2c5f7136b39b862
https://doi.org/10.1053/j.gastro.2010.11.004
https://doi.org/10.1053/j.gastro.2010.11.004
Autor:
Martin Stanulla, Elke Schäffeler, Stefan Arens, Anke Rathmann, André Schrauder, Karl Welte, a Karl Welte, Ulrich M. Zanger, Martin Schrappe, Matthias Schwab
Publikováno v:
International journal of hematology. 81(1)
The probability of event-free survival of childhood acute lymphoblastic leukemia (ALL) approaches 80% or more with the use of modern multiagent chemotherapeutic regimens. One major contribution to this success has been reduction of the rate of centra
Autor:
Matthias, Schwab, Elke, Schäffeler, Claudia, Marx, Christine, Fischer, Thomas, Lang, Christoph, Behrens, Michael, Gregor, Michel, Eichelbaum, Ulrich M, Zanger, Bernd A, Kaskas
Publikováno v:
Pharmacogenetics. 12(6)
The efficacy of the immunosuppressants azathioprine and 6-mercaptopurine has been well established in the therapy of inflammatory bowel diseases (IBD). However, its use has been complicated by a high incidence of serious adverse drug reactions such a
Autor:
Wolf-Dieter Ludwig, Martin Schrappe, André Schrauder, Martin Stanulla, Elke Schäffeler, Karl Welte, Michel Eichelbaum, Jochen Harbott, Silke Pohlschmidt, Martin Zimmermann, Matthias Schwab, Anja Möricke, Alfred Reiter, Gunnar Cario
Publikováno v:
Blood. 114:2625-2625
Abstract 2625 Poster Board II-601 The thiopurines 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) play an essential role in treatment protocols for acute lymphoblastic leukemia (ALL). Thiopurine methyltransferase (TPMT) is a key enzyme in the metabo
Autor:
Thomas Flohr, Elke Schäffeler, Zanger Ulrich, Gunnar Cario, Karl Welte, Bartram R. Claus, Eichelbaum Michel, Schwab Matthias, Schrappe Martin, Martin Stanulla
Publikováno v:
Blood. 104:321-321
Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyzes the S-methylation of thiopurines. The TPMT locus is subject to genetic polymorphism, with heterozygous individuals (about 10% of Caucasians) having intermediate, and homozygou