Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Elke Scandella"'
Autor:
Hung-Wei Cheng, Urs Mörbe, Mechthild Lütge, Céline Engetschwiler, Lucas Onder, Mario Novkovic, Cristina Gil-Cruz, Christian Perez-Shibayama, Thomas Hehlgans, Elke Scandella, Burkhard Ludewig
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Fibroblastic reticular cells (FRCs) support localisation of immune cells in secondary lymphoid tissues but less is known about the lamina propria. Here the authors use scRNA-seq and intestinal infection to characterise FRCs in the intestinal lamina p
Externí odkaz:
https://doaj.org/article/5177e30fc0bf4ed8936c55924e88ee55
Autor:
Sandra S. Ring, Jovana Cupovic, Lucas Onder, Mechthild Lütge, Christian Perez-Shibayama, Cristina Gil-Cruz, Elke Scandella, Angelina De Martin, Urs Mörbe, Fabienne Hartmann, Robert Wenger, Matthias Spiegl, Andrej Besse, Weldy V. Bonilla, Felix Stemeseder, Sarah Schmidt, Klaus K. Orlinger, Philippe Krebs, Burkhard Ludewig, Lukas Flatz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Lymphocytic choriomeningitis virus (LCMV)-based viral vectors have been shown to induce potent antitumor immune responses. Here the authors show that a LCMV-based vaccine vector remodels the tumor-associated fibroblastic stroma, sustaining CD8+ T cel
Externí odkaz:
https://doaj.org/article/6b57b0ebdd6c41a2b423f124d18a7987
Autor:
Hung-Wei Cheng, Lucas Onder, Mario Novkovic, Charlotte Soneson, Mechthild Lütge, Natalia Pikor, Elke Scandella, Mark D. Robinson, Jun-ichi Miyazaki, Anne Tersteegen, Ursula Sorg, Klaus Pfeffer, Thomas Rülicke, Thomas Hehlgans, Burkhard Ludewig
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The white pulp of spleen is an important immune structure dynamically modulated during development and immune responses. Here the authors define, using multi-color lineage tracing and single-cell transcriptome analysis, the subset distribution and di
Externí odkaz:
https://doaj.org/article/ba256f3e23034aedb297741e8c98ad23
Autor:
Lalit Kumar Dubey, Luc Lebon, Ilaria Mosconi, Chen-Ying Yang, Elke Scandella, Burkhard Ludewig, Sanjiv A. Luther, Nicola L. Harris
Publikováno v:
Cell Reports, Vol 15, Iss 7, Pp 1527-1541 (2016)
Summary: Secondary lymphoid tissues provide specialized niches for the initiation of adaptive immune responses and undergo a remarkable expansion in response to inflammatory stimuli. Although the formation of B cell follicles was previously thought t
Externí odkaz:
https://doaj.org/article/4f035fabecdb4162ad2352ecefc3fccb
Autor:
Mario Novkovic, Lucas Onder, Jovana Cupovic, Jun Abe, David Bomze, Viviana Cremasco, Elke Scandella, Jens V Stein, Gennady Bocharov, Shannon J Turley, Burkhard Ludewig
Publikováno v:
PLoS Biology, Vol 14, Iss 7, p e1002515 (2016)
Fibroblastic reticular cells (FRCs) form the cellular scaffold of lymph nodes (LNs) and establish distinct microenvironmental niches to provide key molecules that drive innate and adaptive immune responses and control immune regulatory processes. Her
Externí odkaz:
https://doaj.org/article/afacd1170e1b46d2837051a68b3869c0
Autor:
Akira Takeda, Daichi Kobayashi, Keita Aoi, Naoko Sasaki, Yuki Sugiura, Hidemitsu Igarashi, Kazuo Tohya, Asuka Inoue, Erina Hata, Noriyuki Akahoshi, Haruko Hayasaka, Junichi Kikuta, Elke Scandella, Burkhard Ludewig, Satoshi Ishii, Junken Aoki, Makoto Suematsu, Masaru Ishii, Kiyoshi Takeda, Sirpa Jalkanen, Masayuki Miyasaka, Eiji Umemoto
Publikováno v:
eLife, Vol 5 (2016)
Lymph nodes (LNs) are highly confined environments with a cell-dense three-dimensional meshwork, in which lymphocyte migration is regulated by intracellular contractile proteins. However, the molecular cues directing intranodal cell migration remain
Externí odkaz:
https://doaj.org/article/8c5064af0fe4434a9e972e595071c07d
Autor:
Annette Oxenius, Nicholas M. Provine, Burkhard Ludewig, Daniel S. Engeler, Sandra S. Ring, Hung Wei Cheng, Jovana Cupovic, Julia M Colston, Lukas Flatz, Paul Klenerman, Lucas Onder, Elke Scandella, Mechthild Lütge, Angelina De Martin, Philippe Krebs
Publikováno v:
Nature Immunology. 22:1042-1051
Pathogens and vaccines that produce persisting antigens can generate expanded pools of effector memory CD8+ T cells, described as memory inflation. While properties of inflating memory CD8+ T cells have been characterized, the specific cell types and
Autor:
Hung-Wei Cheng, Urs Mörbe, Mechthild Lütge, Céline Engetschwiler, Lucas Onder, Mario Novkovic, Cristina Gil-Cruz, Christian Perez-Shibayama, Thomas Hehlgans, Elke Scandella, Burkhard Ludewig
Publikováno v:
Nature communications. 13(1)
Innate lymphoid cells (ILCs) govern immune cell homeostasis in the intestine and protect the host against microbial pathogens. Various cell-intrinsic pathways have been identified that determine ILC development and differentiation. However, the cellu
Autor:
Jovana, Cupovic, Sandra S, Ring, Lucas, Onder, Julia M, Colston, Mechthild, Lütge, Hung-Wei, Cheng, Angelina, De Martin, Nicholas M, Provine, Lukas, Flatz, Annette, Oxenius, Elke, Scandella, Philippe, Krebs, Daniel, Engeler, Paul, Klenerman, Burkhard, Ludewig
Publikováno v:
Nature immunology. 22(8)
Pathogens and vaccines that produce persisting antigens can generate expanded pools of effector memory CD8
Autor:
Angelina De Martin, Elke Scandella, Mechthild Lütge, Christian Perez-Shibayama, Cristina Gil-Cruz, Céline Engetschwiler, Nicola Harris, Graham S Le Gros, Burkhard Ludewig
Publikováno v:
The Journal of Immunology. 206:65.09-65.09
Interleukin-33 (IL-33) is a nuclear cytokine of the interleukin-1 family and is released upon cell damage thereby acting as an alarmin. IL-33 plays an essential role in promoting host-protective immune responses against helminth parasites at differen