Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Elke Raderschall"'
Publikováno v:
Proceedings of the National Academy of Sciences. 96:1921-1926
A sensitive and rapid in situ method was developed to visualize sites of single-stranded (ss) DNA in cultured cells and in experimental test animals. Anti-bromodeoxyuridine antibody recognizes the halogenated base analog incorporated into chromosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c63f4e75464224a1360ff9f4bcada89
https://doi.org/10.1073/pnas.96.5.1921
https://doi.org/10.1073/pnas.96.5.1921
Autor:
Charles M. Radding, Thomas Haaf, Efim I. Golub, Elke Raderschall, Gurucharan Reddy, David C. Ward
Publikováno v:
The Journal of Cell Biology
The mammalian Rad51 protein is involved in homologous recombination and in DNA damage repair. Its nuclear distribution after DNA damage is highly dynamic, and distinct foci of Rad51 protein, distributed throughout the nuclear volume, are induced with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13958b41ae846f41a3f302d1da54572
https://doi.org/10.1083/jcb.144.1.11
https://doi.org/10.1083/jcb.144.1.11
Autor:
Elke Raderschall, João T. Barata, Stephen E. Sallan, Lee M. Nadler, Ana Batista, Angelo A. Cardoso, Nadia Carlesso
Publikováno v:
Experimental hematology. 39(4)
Objective Rationally designed therapies aim at the specific disruption of critical signaling pathways activated by malignant transformation or signals from the tumor microenvironment. Because mammalian target of rapamycin (mTOR) is an important signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2810df583e2d3c8c53dd449a2e0732
https://pubmed.ncbi.nlm.nih.gov/21277936
https://pubmed.ncbi.nlm.nih.gov/21277936
Autor:
Keith S. Wilson, Volker A. Erdmann, Zbigniew Dauter, Elke Raderschall, Siegfried Lorenz, Christian Betzel
Publikováno v:
Journal of Molecular Biology. 219:399-402
Crystals of purified 5 S rRNA from Thermus flavus have been obtained. The crystals diffract up to 8 A resolution, using synchrotron radiation, and have the monoclinic space-group C2 . The unit cell has the dimensions a = 190 A , b = 110 A , c = 138 A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df8357e6f9bf6ea4a71d6bb4c5f0223
https://doi.org/10.1016/0022-2836(91)90181-5
https://doi.org/10.1016/0022-2836(91)90181-5
Autor:
Christine Canning, Roberto Bellucci, Jerome Ritz, Haesook T. Kim, Fabrice Porcheray, David A. Frank, Emmanuel Zorn, Mehrdad Mohseni, Despina Litsa, Erik A. Nelson, Robert J. Soiffer, Elke Raderschall
Publikováno v:
Blood. 108(5)
IL-2 plays a critical role in the maintenance of CD4+CD25+ FOXP3+ regulatory T cells (Tregs) in vivo. We examined the effects of IL-2 signaling in human Tregs. In vitro, IL-2 selectively up-regulated the expression of FOXP3 in purified CD4+CD25+ T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92e02c7deb20c5d79b486cda8cce5e9
https://pubmed.ncbi.nlm.nih.gov/16645171
https://pubmed.ncbi.nlm.nih.gov/16645171
Autor:
Thomas Haaf, John M. Sedivy, Elke Raderschall, Avril Smith, Rudi Lurz, Alex V. Bazarov, Eberhard Fritz, Jiangping Cao, Hans-Hilger Ropers, Efim I. Golub, Wolfgang Mann
Publikováno v:
Journal of cell science. 115(Pt 1)
After exposure of mammalian cells to DNA damage, the endogenous Rad51 recombination protein is concentrated in multiple discrete foci, which are thought to represent nuclear domains for recombinational DNA repair. Overexpressed Rad51 protein forms fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f169ad6c80162d1796d5d694766a5054
https://pubmed.ncbi.nlm.nih.gov/11801733
https://pubmed.ncbi.nlm.nih.gov/11801733
Autor:
Elke, Raderschall, Karen, Stout, Susanne, Freier, Vanessa, Suckow, Susann, Schweiger, Thomas, Haaf
Publikováno v:
Cancer research. 62(1)
Rad51 is the key enzyme for homologous recombination, an evolutionarily conserved mechanism for the repair of DNA damage and the generation of genetic diversity. Given the observation that many tumors become resistant to radiation therapy and DNA-dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03538fe45d571ae7fc4c31b471c2ea70
https://pubmed.ncbi.nlm.nih.gov/11782381
https://pubmed.ncbi.nlm.nih.gov/11782381
Autor:
Ross L. Levine, Jennifer R. Brown, Arnold S. Freedman, Elke Raderschall, Christina Thompson, D. Gary Gilliland
Publikováno v:
Blood. 110:2069-2069
Genomic screens have identified activating somatic mutations in tyrosine kinases in a spectrum of acute and chronic hematologic malignancies. These mutations lead to increased cellular proliferation and/or impairment of apoptosis. Chronic lymphocytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ece28d63595ee2737c125f256e644b08
https://doi.org/10.1182/blood.v110.11.2069.2069
https://doi.org/10.1182/blood.v110.11.2069.2069
Publikováno v:
Blood. 108:818-818
Although an inherited contribution to CLL/SLL and Hodgkin’s lymphoma (HL) is increasingly accepted, the contribution of inherited predisposition to non-Hodgkin’s lymphomas has been less well studied. The frequency of families with more than one B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1af6f5b4ca881b055976bf4f6daada99
https://doi.org/10.1182/blood.v108.11.818.818
https://doi.org/10.1182/blood.v108.11.818.818
Autor:
Elke, Raderschall, Alex, Bazarov, Jiangping, Cao, Rudi, Lurz, Avril, Smith, Wolfgang, Mann, Hans-Hilger, Ropers, M, Sedivy John, I, Golub Efim, Eberhard, Fritz, Thomas, Haaf
Publikováno v:
Journal of Cell Science; January 2002, Vol. 115 Issue: 1 p153-64, 12p