Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Elke Pravda"'
Autor:
Elke Pravda, Irit Adini, Kaustabh Ghosh, Ofra Benny, Robert J. D'Amato, Dema Luyindula, Avner Adini, Ron Hu
Publikováno v:
Angiogenesis. 16:405-416
Prominin-1, a pentaspan transmembrane protein, is a unique cell surface marker commonly used to identify stem cells, including endothelial progenitor cells and cancer stem cells. However, recent studies have shown that prominin-1 expression is not re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ddabbe934f4a480417b1e79fccf2789
https://doi.org/10.1007/s10456-012-9323-8
https://doi.org/10.1007/s10456-012-9323-8
Publikováno v:
Journal of Investigative Dermatology. 130(5):1307-1317
UV light-based damage to skin cells can cause photoaging and skin cancer. A major cause of UV light-induced damage to skin is increased free radicals, such as superoxides. Increased superoxides can cause oxidative and nitrative damage to cell compone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a1622a3d12a9ac3fcbf213acbf728f
Autor:
Elke Pravda, Akio Shimizu, Donald E. Ingber, Andrew C. Dudley, Joseph E. Italiano, Michael Klagsbrun, Akiko Mammoto
Publikováno v:
Journal of Biological Chemistry. 283:27230-27238
Class three semaphorins (SEMAs) were originally shown to be mediators of axon guidance that repelled axons and collapsed growth cones, but it is now evident that SEMA3F, for example, has similar effects on tumor cells and endothelial cells (EC). In b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c49a96025457f409bc1ded2d0ab6b30
https://doi.org/10.1074/jbc.m804520200
https://doi.org/10.1074/jbc.m804520200
Autor:
Elke Pravda, Robert J. D'Amato, Ofra Benny, Ofer Fainaru, Irit Adini, Lauren Bazinet, Judah Folkman
Publikováno v:
The FASEB Journal. 22:3728-3735
The endothelium lining blood vessels serves as a barrier against vascular hyperpermeability, and its maintenance is critical to organ health. Inflammatory mediators evoke tissue edema by disrupting the expression of membrane junctional proteins, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c86f3c7345521b75e69227bbfd293d
https://doi.org/10.1096/fj.08-110494
https://doi.org/10.1096/fj.08-110494
Autor:
Lauren Bazinet, Judah Folkman, Flavia Cassiola, Robert J. D'Amato, Elke Pravda, Avner Adini, Yaakov Nahmias, Ofer Fainaru, Gabriel Corfas, Samir Koirala, Ofra Benny, Irit Adini
Publikováno v:
Nature Biotechnology. 26:799-807
Targeting angiogenesis, the formation of blood vessels, is an important modality for cancer therapy. TNP-470, a fumagillin analog, is among the most potent and broad-spectrum angiogenesis inhibitors. However, a major clinical limitation is its poor o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7750195c5b998edcca485ba75dee8669
https://doi.org/10.1038/nbt1415
https://doi.org/10.1038/nbt1415
Autor:
Judah Folkman, Ofer Fainaru, Avner Adini, Sarah P. Short, Lauren Bazinet, Irit Adini, Kei Nakai, Robert J. D'Amato, Elke Pravda, Mark D. Hornstein, Ofra Benny
Publikováno v:
The FASEB Journal. 22:522-529
Endometriosis affects 10-15% of women and is associated with pelvic pain and infertility. Angiogenesis plays an essential role in its pathogenesis. Dendritic cells (DCs) were recently implicated in supporting tumor angiogenesis. As both tumors and en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e17eff98d2d93420c180c9c220a997d
https://doi.org/10.1096/fj.07-9034com
https://doi.org/10.1096/fj.07-9034com
Angiostatin, a proteolytic fragment of plasminogen, is a potent endogenous antiangiogenic agent. The molecular mechanisms governing angiostatin's antiangiogenic and antitumor effects are not well understood. Here, we report the identification of mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a5d5f0626f9fdf6da50e91a55b8310
https://europepmc.org/articles/PMC2738581/
https://europepmc.org/articles/PMC2738581/
Autor:
Nesreen S. Ismail, Jean Lai, Rick A. Rogers, Susan M. Dallabrida, Elke Pravda, Flávia Cassiola, Renee Dickie, Emily M. Parodi, Ellen M. Durand, Maria Rupnick
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 22(8)
Angiopoietins were thought to be endothelial cell-specific via the tie2 receptor. We showed that angiopoietin-1 (ang1) also interacts with integrins on cardiac myocytes (CMs) to increase survival. Because ang1 monomers bind and activate integrins (no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5b23519942ec2b745ea2274a4b6c65
https://pubmed.ncbi.nlm.nih.gov/18502941
https://pubmed.ncbi.nlm.nih.gov/18502941
Autor:
Kei Nakai, Lauren Bazinet, Pouya Pakneshan, Robert J. D'Amato, Ofra Benny, Elke Pravda, Judah Folkman, Ofer Fainaru
Publikováno v:
Investigative ophthalmologyvisual science. 49(8)
Purpose Dendritic cells (DCs) are innate immune cells that have recently been shown to support angiogenesis in tumors, endometriosis, and lymph nodes. A major cause of legal blindness is wet age-related macular degeneration (wet ARMD), wherein abnorm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0c6e52d247818d407b5920902d7fa3
https://pubmed.ncbi.nlm.nih.gov/18408184
https://pubmed.ncbi.nlm.nih.gov/18408184
Autor:
Kin-Ming Lo, Robert M. Tjin Tham Sjin, Kashi Javaherian, Judah Folkman, Bissan Ahmed, Stephen D. Gillies, Tong-Young Lee, Elke Pravda, Shahla Movahedi
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 14(5)
Purpose: The half-life of the antiangiogenic molecule endostatin that has been used in clinical trial is short (∼2 h). In addition, ∼50% of the clinical grade endostatin molecules lack four amino acids at their NH2 termini. Lack of these amino ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6943db5ecea5af0f96a381273b6fd92
https://pubmed.ncbi.nlm.nih.gov/18316573
https://pubmed.ncbi.nlm.nih.gov/18316573