Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Elke Leupolt"'
Autor:
Sandrine Sander, Lars Bullinger, Elke Leupolt, Axel Benner, Dirk Kienle, Tiemo Katzenberger, Jörg Kalla, German Ott, Hans Konrad Müller-Hermelink, Thomas F.E. Barth, Peter Möller, Peter Lichter, Hartmut Döhner, Stephan Stilgenbauer
Publikováno v:
Haematologica, Vol 93, Iss 5 (2008)
Background The genetic hallmark of mantle cell lymphoma is a t(11;14)(q13;q32). However, additional genomic alterations are likely involved in the pathogenesis of this lymphoma.Design and Methods To determine the incidence and clinical relevance of t
Externí odkaz:
https://doaj.org/article/902bcc3bec2f4ccf9bff908e95af5353
Autor:
Stephan Stilgenbauer, Sandrine Sander, Lars Bullinger, Axel Benner, Elke Leupolt, Dirk Winkler, Alexander Kröber, Dirk Kienle, Peter Lichter, Hartmut Döhner
Publikováno v:
Haematologica, Vol 92, Iss 9 (2007)
In chronic lymphocytic leukemia (CLL), the acquisition of new genomic aberrations during the disease course (clonal evolution) is thought to be an infrequent phenomenon but comprehensive analyses are limited. Genomic aberrations were analyzed by fluo
Externí odkaz:
https://doaj.org/article/928d36c29b1a4ad782bcdfeaf0cf9b40
Autor:
Thomas F. E. Barth, Stephan Stilgenbauer, Dirk Kienle, Peter Möller, Tiemo Katzenberger, Jörg Kalla, Hans Konrad Müller-Hermelink, Axel Benner, Sandrine Sander, Hartmut Döhner, Lars Bullinger, Peter Lichter, Elke Leupolt, German Ott
Publikováno v:
Haematologica. 93:680-687
Background The genetic hallmark of mantle cell lymphoma is a t(11;14)(q13;q32). However, additional genomic alterations are likely involved in the pathogenesis of this lymphoma.Design and Methods To determine the incidence and clinical relevance of t
Autor:
Peter Lichter, Stephan Stilgenbauer, Axel Benner, Hartmut Döhner, Dirk Kienle, Alexander Kröber, Elke Leupolt, Dirk Winkler, Sandrine Sander, Lars Bullinger
Publikováno v:
Haematologica. 92:1242-1245
In chronic lymphocytic leukemia (CLL), the acquisition of new genomic aberrations during the disease course (clonal evolution) is thought to be an infrequent phenomenon but comprehensive analyses are limited. Genomic aberrations were analyzed by fluo
Autor:
Axel Benner, Peter Möller, P. Lichter, Hans Konrad Müller-Hermelink, Annett Habermann, Martin Bentz, Thomas F. E. Barth, Stephan Stilgenbauer, Hartmut Döhner, German Ott, Alexander Kröber, Dirk Kienle, Elke Leupolt, Tiemo Katzenberger
Publikováno v:
Blood. 102:3003-3009
Immunoglobulin variable heavy chain gene (VH) mutation status and VDJ rearrangement structure were analyzed in 141 patients with mantle cell lymphoma (MCL) and correlated with biologic and clinical characteristics; 29% of the MCLs displayed mutated V
Autor:
Peter Lichter, Hartmut Döhner, Alexander Kröber, Elke Leupolt, Martin Bentz, Lars Bullinger, Axel Benner, Stephan Stilgenbauer, Konstanze Döhner
Publikováno v:
New England Journal of Medicine. 343:1910-1916
Fluorescence in situ hybridization has improved the detection of genomic aberrations in chronic lymphocytic leukemia. We used this method to identify chromosomal abnormalities in patients with chronic lymphocytic leukemia and assessed their prognosti
Autor:
Stephan Stilgenbauer, Hartmut Döhner, German Ott, Peter Möller, Peter Lichter, Elke Leupolt, Dirk Winkler, Michael R. James, Claudia Schaffner, Hans K. Müller-Hermelink, Martin Bentz
Publikováno v:
Blood. 94:3262-3264
Deletions involving the long arm of chromosome 11 (11q) have been recently found as recurrent chromosome aberrations in mantle cell lymphoma (MCL). In the current study, the incidence and molecular extent of 11q deletions were analyzed in a series of
Autor:
Claudia Schaffner, Stephan Stilgenbauer, Daniel Mertens, Peter Lichter, Elke Leupolt, Christian Korz, Axel Benner, Hartmut Döhner, Armin Pscherer
Publikováno v:
Blood. 99(12)
The B-cell lymphoproliferative malignancies B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma (MCL) share characteristics, including overlapping chromosomal aberrations with deletions on chromosome bands 13q14, 11q23, 17p13, and 6q
Autor:
Hartmut Döhner, Lars Bullinger, Claudia Schaffner, P. Lichter, Martin Bentz, Elke Leupolt, Stephan Stilgenbauer, Daniel Mertens
Publikováno v:
Leukemia. 14(8)
The BCL10 gene has recently been cloned from the 1p22 breakpoint of the translocation t(1 ;14)(p22;q32) observed in mucosa-associated lymphoid tissue (MALT) lymphoma. BCL10 was shown to be a proapoptotic-signaling gene encoding a protein that contain
Autor:
Peter Lichter, Claudia Schaffner, Elke Leupolt, Hans Konrad Müller-Hermelink, Hartmut Döhner, S. Stilgenbauer, Peter Möller, Michael R. James, Martin Bentz, Dirk Winkler, German Ott
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 11
iWellcome Trust Centre for Human Genetics, Oxford, UK Summary Background: Mantle-cell lymphoma (MCL) is genetically characterized by the translocation t(ll;14)(ql3;q32) leading to an overexpression of cyclin-Dl, but additional chromosomal abnormaliti