Výsledky vyhledávání - "Elke Langkopf"

3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: A class of potent DPP-4 inhibitors

Autor: Frank Himmelsbach, Ralf Lotz, Moh Tadayyon, Elke Langkopf, Herbert Nar, Norbert Hauel, Leo Thomas, Matthias Eckhardt, Michael Mark, Brian Guth

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:3158-3162

Systematic variations of the xanthine scaffold in close analogs of development compound BI 1356 led to the class of 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones which provided, after substituent screening, a series of highly potent DPP-4 inhibitors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b59de9fefdb0ce2e2888c2d4574bfc
https://doi.org/10.1016/j.bmcl.2008.04.075

Zobrazit plný text záznamu

Synthesis of 2-bromo-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and 3-alkyl-2-bromo-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and their selective elaboration

Autor: Matthias Eckhardt, Norbert Hauel, Elke Langkopf, Frank Himmelsbach

Publikováno v: Tetrahedron Letters. 49:1931-1934

Two synthetic routes to the versatile 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones 2 and 5 have been developed that allow the production of multigram quantities without the need of any chromatographic purification. Broad and selective elaboration of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7335322c41a8553b0ba400157a62082
https://doi.org/10.1016/j.tetlet.2008.01.102

Zobrazit plný text záznamu

The first metal-catalyzed intramolecular [5+2] cycloadditions of vinylcyclopropanes and alkenes: Scope, stereochemistry, and asymmetric catalysis

Autor: Elke Langkopf, Paul A. Wender, Craig O. Husfeld, Norbert Pleuss, Jennifer A. Love

Publikováno v: Tetrahedron. 54:7203-7220

The first studies of the metal-catalyzed [5+2] cycloadditions of vinylcyclopropanes and alkenes are described. These reactions proceed with exceptional diastereoselectivity and in good to excellent yields. The effect of tether and substituent variati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a458be5cbbf418f1dde050cf4fc5d92
https://doi.org/10.1016/s0040-4020(98)00355-x

Zobrazit plný text záznamu

ChemInform Abstract: The First Metal-Catalyzed Intramolecular [5 + 2] Cycloadditions of Vinylcyclopropanes and Alkenes: Scope, Stereochemistry, and Asymmetric Catalysis

Autor: Elke Langkopf, Craig O. Husfeld, Jennifer A. Love, Paul A. Wender, Norbert Pleuss

Publikováno v: ChemInform. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74e0aa8dd7fceec3306c06c3436eb5b2
https://doi.org/10.1002/chin.199840069

Zobrazit plný text záznamu

ChemInform Abstract: 3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: A Class of Potent DPP-4 Inhibitors

Autor: Moh Tadayyon, Matthias Eckhardt, Herbert Nar, Ralf Lotz, Leo Thomas, Michael Mark, Elke Langkopf, Frank Himmelsbach, Brian Guth, Norbert Hauel

Publikováno v: ChemInform. 39

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9b89a3c4af9d220e123ff7b143d9cff
https://doi.org/10.1002/chin.200842147

Zobrazit plný text záznamu

(R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors

Autor: Michael Mark, Moh Tadayyon, Elke Langkopf, Frank Himmelsbach, Leo Thomas, Matthias Eckhardt

Publikováno v: The Journal of pharmacology and experimental therapeutics. 325(1)

BI 1356 [proposed trade name ONDERO; (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione] is a novel dipeptidyl peptidase (DPP)-4 inhibitor under clinical development for the treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89660059f143963743aafcbc94d447d5
https://pubmed.ncbi.nlm.nih.gov/18223196

Zobrazit plný text záznamu

Molecular recognition of the protein phosphatase 1 glycogen targeting subunit by glycogen phosphorylase

Autor: Oliver Wissdorf, Elke Langkopf, Nadja Stadler, Ruediger Streicher, Werner Moreth, Alexander Pautsch

Publikováno v: The Journal of biological chemistry. 283(14)

Disrupting the interaction between glycogen phosphorylase and the glycogen targeting subunit (G(L)) of protein phosphatase 1 is emerging as a novel target for the treatment of type 2 diabetes. To elucidate the molecular basis of binding, we have dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa253683410a035e8e9665a433720943
https://pubmed.ncbi.nlm.nih.gov/18198182

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání