Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Elke Grönniger"'
Autor:
Cassandra Falckenhayn, Agata Bienkowska, Jörn Söhle, Katrin Wegner, Guenter Raddatz, Boris Kristof, Dirk Kuck, Ralf Siegner, Ronny Kaufmann, Julia Korn, Sascha Baumann, Daniela Lange, Andreas Schepky, Henry Völzke, Lars Kaderali, Marc Winnefeld, Frank Lyko, Elke Grönniger
Publikováno v:
Frontiers in Aging, Vol 4 (2024)
Changes in DNA methylation patterning have been reported to be a key hallmark of aged human skin. The altered DNA methylation patterns are correlated with deregulated gene expression and impaired tissue functionality, leading to the well-known skin a
Externí odkaz:
https://doaj.org/article/41b18a4c3c734ca79c31cb048d5cc259
Autor:
Agata Bienkowska, Günter Raddatz, Jörn Söhle, Boris Kristof, Henry Völzke, Stefan Gallinat, Frank Lyko, Lars Kaderali, Marc Winnefeld, Elke Grönniger, Cassandra Falckenhayn
Publikováno v:
Frontiers in Aging, Vol 4 (2024)
Aging is a complex process characterized by the gradual decline of physiological functions, leading to increased vulnerability to age-related diseases and reduced quality of life. Alterations in DNA methylation (DNAm) patterns have emerged as a funda
Externí odkaz:
https://doaj.org/article/1a63eb2abbed48d0819a01c6a91f55a4
Autor:
Nicholas Holzscheck, Cassandra Falckenhayn, Jörn Söhle, Boris Kristof, Ralf Siegner, André Werner, Janka Schössow, Clemens Jürgens, Henry Völzke, Horst Wenck, Marc Winnefeld, Elke Grönniger, Lars Kaderali
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-13 (2021)
Abstract The development of ‘age clocks’, machine learning models predicting age from biological data, has been a major milestone in the search for reliable markers of biological age and has since become an invaluable tool in aging research. Howe
Externí odkaz:
https://doaj.org/article/777c395850e541569fc03b8d41e94be4
Autor:
Juliane M. D. Ahlers, Cassandra Falckenhayn, Nicholas Holzscheck, Llorenç Solé-Boldo, Sabrina Schütz, Horst Wenck, Marc Winnefeld, Frank Lyko, Elke Grönniger, Annette Siracusa
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
The dermal sheath (DS) is a population of mesenchyme-derived skin cells with emerging importance for skin homeostasis. The DS includes hair follicle dermal stem cells, which exhibit self-renewal and serve as bipotent progenitors of dermal papilla (DP
Externí odkaz:
https://doaj.org/article/82567bf8e9dd4fdd8d40c86e56bece2d
Autor:
Alfred Gugerell, Johanna Kober, Thorsten Laube, Torsten Walter, Sylvia Nürnberger, Elke Grönniger, Simone Brönneke, Ralf Wyrwa, Matthias Schnabelrauch, Maike Keck
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90676 (2014)
An irreversible loss of subcutaneous adipose tissue in patients after tumor removal or deep dermal burns makes soft tissue engineering one of the most important challenges in biomedical research. The ideal scaffold for adipose tissue engineering has
Externí odkaz:
https://doaj.org/article/37939e9f1e614dfeb8a064a0b0f5fff7
Autor:
Jörn Söhle, Nikolaus Machuy, Elma Smailbegovic, Ursula Holtzmann, Elke Grönniger, Horst Wenck, Franz Stäb, Marc Winnefeld
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31193 (2012)
Since the worldwide increase in obesity represents a growing challenge for health care systems, new approaches are needed to effectively treat obesity and its associated diseases. One prerequisite for advances in this field is the identification of g
Externí odkaz:
https://doaj.org/article/0c747ad74c294637bc43555c5c6378c7
Autor:
Elke Grönniger, Barbara Weber, Oliver Heil, Nils Peters, Franz Stäb, Horst Wenck, Bernhard Korn, Marc Winnefeld, Frank Lyko
Publikováno v:
PLoS Genetics, Vol 6, Iss 5, p e1000971 (2010)
Epigenetic changes are widely considered to play an important role in aging, but experimental evidence to support this hypothesis has been scarce. We have used array-based analysis to determine genome-scale DNA methylation patterns from human skin sa
Externí odkaz:
https://doaj.org/article/59b7f886eefe4ad1a24f12a662097e3c
Autor:
Dennis Roggenkamp, Elke Grönniger, Stefanie Conzelmann, Thorsten Burkhardt, Frank Rippke, Alexander Filbry, Jens-Peter Vietzke, Dörte Segger, Silke Altgilbers
Publikováno v:
Skin Pharmacology and Physiology. 35:102-111
Introduction: Xerosis cutis is characterized by a decreased stratum corneum (SC) hydration and an impaired skin barrier function. Urea, the most prevalent natural moisturizing factor (NMF), is currently considered the gold standard. Its efficacy can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e124c2193b8b5898fb5e3b782096f64b
https://doi.org/10.1159/000520009
https://doi.org/10.1159/000520009
Autor:
Marc Winnefeld, Nicholas Holzscheck, Cassandra Falckenhayn, Horst Wenck, Katharina Gorges, Lara Terstegen, Elke Grönniger, Ludger Kolbe, Lars Kaderali, Torsten Schläger, Jörn Söhle
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
The simultaneous analysis of different regulatory levels of biological phenomena by means of multi-omics data integration has proven an invaluable tool in modern precision medicine, yet many processes ultimately paving the way towards disease manifes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af9013c4adfe52dd9ad1a30ce0a595f
http://link.springer.com/article/10.1038/s41598-020-69683-8
http://link.springer.com/article/10.1038/s41598-020-69683-8
Autor:
Lars Kaderali, Horst Wenck, Boris Kristof, Jörn Söhle, Marc Winnefeld, Nicholas Holzscheck, Elke Grönniger, Cassandra Falckenhayn, Stefan Gallinat
Publikováno v:
Aging (Albany NY)
In recent years, reports of non-linear regulations in age- and longevity-associated biological processes have been accumulating. Inspired by methodological advances in precision medicine involving the integrative analysis of multi-omics data, we soug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1902be835b546c232db2556a96a826
https://doi.org/10.18632/aging.103499
https://doi.org/10.18632/aging.103499