Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Elke Gerlach"'
Autor:
Markus Rehm, Elke Gerlach, Cristiano Guttà, Biswajit Podder, Diana Panayotova-Dimitrova, Martin Leverkus, Leonidas G. Alexopoulos, Maria Feoktistova, Jan Rožanc
Publikováno v:
Cell Death Differ
Melanoma cells are highly resistant to conventional genotoxic agents, and BRAFV600/MEK-targeted therapies as well as immunotherapies frequently remain inefficient. Alternative means to treat melanoma, in particular through the induction of programmed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd5395015c2ce3e5b47df35a6ee1778
https://pubmed.ncbi.nlm.nih.gov/30850732
https://pubmed.ncbi.nlm.nih.gov/30850732
Publikováno v:
Journal of Chromatography A. 1236:90-96
In this manuscript we describe the two-step purification of a mono-PEGylated anti-epidermal growth factor receptor (EGFR) single-chain Fv. A weak cation exchanger was used for capture. Elution using arginine suppressed protein aggregation and allowed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4514ebe7d8b4bad97ac811cd75b7175
https://doi.org/10.1016/j.chroma.2012.03.004
https://doi.org/10.1016/j.chroma.2012.03.004
Autor:
Klaus Pfizenmaier, Debola Banerjee, Jeannette Gerspach, Dieter Moosmayer, Elke Gerlach, Thomas Wüest
Publikováno v:
Oncogene. 21:4257-4265
We describe a TNF fusion protein designated TNF-Selectokine, which is a homo-trimeric molecule comprised of a single chain antibody (scFv) targeting module, a trimerization domain and TNF. TNF-Selectokine exerts high bioactivity towards the targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02085fb78aeb60831a60d6a1d33288b
https://doi.org/10.1038/sj.onc.1205193
https://doi.org/10.1038/sj.onc.1205193
Autor:
Wolfgang J. Rettig, Pilar Garin-Chesa, Dieter Moosmayer, Dafne Müller, Elke Gerlach, Thomas Wüest, Michael Mersmann, Klaus Pfizenmaier, Alexej Schmidt
Publikováno v:
European Journal of Biochemistry. 268:1730-1738
Four completely human antibody derivatives [single-chain-antibody fragments (scFvs)] with specificity for the general tumor stroma marker fibroblast activation protein (FAP) were isolated by guided selection. Highly diverse IgG, IgM and IgD isotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fddfd26edbd5865a6ff3de7550800b34
https://doi.org/10.1046/j.1432-1327.2001.02046.x
https://doi.org/10.1046/j.1432-1327.2001.02046.x
Autor:
Klaus Pfizenmaier, Dieter Moosmayer, Bodo Brocks, Harald Wajant, Elke Gerlach, Mathias Schmidt
Publikováno v:
Journal of Interferon & Cytokine Research. 16:471-477
Different soluble human TNFR80 derivatives, a solubilized form of the complete TNFR80, the TNFR80 extracellular domain, a secretory TNFR80 mutant (TR80TM-) with a deleted transmembrane region, and a TNFR80 immunoadhesin were produced in insect cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e002e7446a52a1db1b3e8ef5151f08
https://doi.org/10.1089/jir.1996.16.471
https://doi.org/10.1089/jir.1996.16.471
Autor:
Roland Hauff, Bodo Brocks, Klaus Pfizenmaier, Dieter Moosmayer, Elke Gerlach, Pascale De Becker
Publikováno v:
Journal of Interferon & Cytokine Research. 15:1111-1115
We describe here the bioengineering of a bivalent IFN-gamma-RFc immunoadhesin consisting of the extracellular domain of the human IFN-gamma receptor alpha chain (IFN-gamma-R) fused to a human IgG1 Fc region (encoding hinge, CH2 and CH3 domain) that w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1a1e3c1a721f008621d789a4c496cb
https://doi.org/10.1089/jir.1995.15.1111
https://doi.org/10.1089/jir.1995.15.1111
Autor:
Alexej Schmidt, Dafne Muller, Michael Mersmann, Thomas Wuest, Elke Gerlach, Pilar Garin-Chesa, Wolfgang J. Rettig, Klaus Pfizenmaier, Dieter Moosmayer
Publikováno v:
European journal of biochemistry. 268(6)
Four completely human antibody derivatives [single-chain-antibody fragments (scFvs)] with specificity for the general tumor stroma marker fibroblast activation protein (FAP) were isolated by guided selection. Highly diverse IgG, IgM and IgD isotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2dda8db4fc71926e519def1beb8844b
https://pubmed.ncbi.nlm.nih.gov/11248693
https://pubmed.ncbi.nlm.nih.gov/11248693
Autor:
Harald Wajant, Nathalie Peters, Elke Gerlach, Klaus Pfizenmaier, Dieter Moosmayer, Ulrike Schönherr, Thomas Wüest, Peter Scheurich, Till Bartke
Publikováno v:
Oncogene. 20(30)
TNF-related apoptosis-inducing ligand (TRAIL) is a typical member of the tumor necrosis factor (TNF) ligand family that is expressed as a type II membrane protein (memTRAIL) and signals apoptosis via the death domain-containing receptors TRAIL-R1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47785c6d33f251f4e3a63f6cefc1c11f
https://pubmed.ncbi.nlm.nih.gov/11494138
https://pubmed.ncbi.nlm.nih.gov/11494138
Publikováno v:
European journal of biochemistry. 244(1)
Here, we describe the production of recombinant human tissue inhibitor of metalloproteinases-1 (rTIMP-1) and wild-type and mutant human collagenase type I (rMMP-1) proteins in SF9 cells by the baculovirus expression system. Wild-type MMP-1, as well a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e082aef65b353dbdd1e592e3cb787efe
https://pubmed.ncbi.nlm.nih.gov/9063449
https://pubmed.ncbi.nlm.nih.gov/9063449