Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Elke Genschow"'
Publikováno v:
Alternatives to laboratory animals : ATLA. 27(6)
To reduce the number of animals used in acute oral toxicity testing, cytotoxicity data (IC50) can be used to determine the starting dose for in vivo testing by applying the standard regression between IC50 and acute oral LD50 values in the Register o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3599847e78170803e760f2c1f72dbc37
https://pubmed.ncbi.nlm.nih.gov/25490464
https://pubmed.ncbi.nlm.nih.gov/25490464
Autor:
Dieter Traue, Ingrid Gerner, Manfred Liebsch, Helena Kandarova, Elisabeth Schmidt, Elke Genschow, Horst Spielmann
Publikováno v:
Alternatives to Laboratory Animals. 33:351-367
During the past decade, several validation studies have been conducted on in vitro methods for discriminating between skin irritating and non-irritating chemicals. The reconstructed human skin models, EpiDerm and EPISKIN, provided the most promising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11dfd733544c7ab867aaedd464caed9
https://doi.org/10.1177/026119290503300408
https://doi.org/10.1177/026119290503300408
Autor:
Ingeborg Pohl, Horst Spielmann, Andrea Seiler, Susanne Bremer, K. Becker, Elke Genschow, Nicole Clemann, Gabriele Scholz
Publikováno v:
Alternatives to Laboratory Animals. 32:209-244
A detailed report is presented on the performance of the embryonic stem cell test (EST) in a European Centre for the Validation of Alternative Methods (ECVAM)-sponsored formal validation study on three in vitro tests for embryotoxicity. Twenty coded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc72b467e9d1886a98149c5ef21dfdb
https://doi.org/10.1177/026119290403200305
https://doi.org/10.1177/026119290403200305
Autor:
Aldert H. Piersma, Elke Genschow, Andrea Seiler, Aart Verhoef, Angie Burns, Nigel A. Brown, Madeleine Brady, Marielle Q I Spanjersberg, Horst Spielmann, Nicole Clemann
Publikováno v:
Alternatives to Laboratory Animals. 32:275-307
A detailed report is presented on the performance of the postimplantation rat whole-embryo culture (WEC) test in a European Centre for the Validation of Alternative Methods (ECVAM)-sponsored formal validation study on three in vitro tests for embryot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67d5c91a6f07a4f37728c8d219e62ef
https://doi.org/10.1177/026119290403200307
https://doi.org/10.1177/026119290403200307
Publikováno v:
Alternatives to Laboratory Animals. 32:713-723
The results of a European Centre for the Validation of Alternative Methods validation study on the embryonic stem (ES) cell test were used as an example for the test performance for “three-class” data using linear discriminant analysis (LDA). App
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da84f8b9e54f1646e554129af11a5da5
https://doi.org/10.1177/026119290403201s119
https://doi.org/10.1177/026119290403201s119
Publikováno v:
Journal of Clinical Microbiology. 41:1062-1068
A standardized broth microdilution method was compared to the E test and an agar dilution method for the antimicrobial susceptibility testing of Campylobacter jejuni and C. coli isolates. A group of 47 human clinical isolates, 37 isolates from retail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f62182b747be4cbd200b1276e958113
https://doi.org/10.1128/jcm.41.3.1062-1068.2003
https://doi.org/10.1128/jcm.41.3.1062-1068.2003
Autor:
Nigel A. Brown, Horst Spielmann, Nicole Clemann, Gabriele Scholz, Susanne Bremer, Madeleine Brady, Hannele Huuskonen, Francoise Paillard, Andrea Seiler, Aldert H. Piersma, Elke Genschow, K. Becker
Publikováno v:
Alternatives to Laboratory Animals. 30:151-176
From 1996 to 2000, ZEBET (Centre for Documentation and Evaluation of Alternative Methods to Animal Experiments at the BgVV, Berlin, Germany) coordinated the European Centre for the Validation of Alternative Methods (ECVAM) prevalidation and validatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59b40af707b3d62720d09d7ff765c56b
https://doi.org/10.1177/026119290203000204
https://doi.org/10.1177/026119290203000204
Publikováno v:
Toxicology in Vitro. 15:447-453
To offer a sensitive and predictive in vitro method to assess germ cell mutagenicity, we established primordial germ (PG) cell-derived permanent female and male embryonic germ (EG) cell lines of the mouse (strain BALB/cJ). The differences in developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a69d0a0ae9a6255a9b8d45a5c160e9d
https://doi.org/10.1016/s0887-2333(01)00050-9
https://doi.org/10.1016/s0887-2333(01)00050-9
Autor:
Hans Raabe, Jacqueline Southee, Suzanne Bremer, Martin Paparella, Ingeborg Pohl, Gabriele Scholz, Horst Spielmann, Elke Genschow
Publikováno v:
Toxicology in Vitro. 13:675-681
Pluripotent embryonic stem cells (ES cells) of the mouse (cell-line D3) can be maintained in the undifferentiated state in the presence of LIF (Leukaemia Inhibitory Factor). Upon withdrawal of LIF, these cells differentiate into various cell types un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8c4a619e7eff1b135a3790dc955fbc
https://doi.org/10.1016/s0887-2333(99)00046-6
https://doi.org/10.1016/s0887-2333(99)00046-6
Publikováno v:
Environmental Management and Health. 8:73-79
Presents the findings of a study conducted to examine the efficiency of the combined anaerobic‐aerobic reactors for the treatment of three different tannery industrial wastewaters, focusing on the fate of chromium and other associated metals. Exami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e84b402cb6fb1ed9928caa6dae232509
https://doi.org/10.1108/09566169710166566
https://doi.org/10.1108/09566169710166566