Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Elke Gülden"'
Publikováno v:
Journal of Diabetes Research, Vol 2018 (2018)
Background. Heat shock proteins (Hsp) act as intracellular chaperones and in addition are used as adjuvant in vaccines of peptides complexed with recombinant Hsp. By interacting with autologous peptides, Hsp may promote the induction of autoimmune re
Externí odkaz:
https://doaj.org/article/04ca8bbcd51d40df82cb73f417dc2d18
Autor:
Elke Gülden, Masaru Ihira, Atsushi Ohashi, Anna Lena Reinbeck, Marina A Freudenberg, Hubert Kolb, Volker Burkart
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75385 (2013)
Background/objectiveToll-like receptors (TLR) mediate the recognition of microbial constituents and stress-induced endogenous ligands by the immune system. They may also be involved in the maintenance or break down of tolerance against autologous ant
Externí odkaz:
https://doaj.org/article/5c6aea1a33e14d68962e75adc416e65c
Autor:
Austen A. Barnett, Robert A. Kazmierczak, Yves C. Chabu, Bakul Dhagat-Mehta, Li Lee, Elke Gülden, Clintin P. Davis-Stober, Lixin Ma
Publikováno v:
Oncotarget
Conventional cancer chemotherapies are not fully efficacious and do not target tumors, leading to significant treatment-related morbidities. A number of genetically attenuated cancer-targeting bacteria are being developed to safely target tumors in v
Publikováno v:
Journal of Diabetes Research, Vol 2018 (2018)
Journal of Diabetes Research
Journal of Diabetes Research
Background. Heat shock proteins (Hsp) act as intracellular chaperones and in addition are used as adjuvant in vaccines of peptides complexed with recombinant Hsp. By interacting with autologous peptides, Hsp may promote the induction of autoimmune re
Autor:
Chen Chao, Li Wen, James A. Pearson, Elke Gülden, Jian Peng, F. Susan Wong, Zhiguang Zhou, Monika Majewska-Szczepanik, Ningwen Tai
Publikováno v:
Journal of Autoimmunity. 93:57-65
The incidence of type 1 diabetes (T1D) is determined by both genetic and environmental factors. In recent years, the gut microbiota have been identified to be an important environmental factor that could modify diabetes susceptibility. We have previo
Autor:
Yun Ma, Fernando Alvarez, Elke Gülden, Isabelle Colle, Muhammed Yuksel, Ningwen Tai, Kathie Béland, Zhao Hu, Xiaoyan Xiao, Pascal Lapierre, Li Wen, G.M. Vijay
Publikováno v:
Clinical and Experimental Immunology. 186:164-176
Summary Autoimmune hepatitis (AIH) is a chronic liver disease characterized by progressive inflammation, female preponderance and seropositivity for autoantibodies such as anti-smooth muscle actin and/or anti-nuclear, anti-liver kidney microsomal typ
Autor:
Elke Gülden
Publikováno v:
Current Diabetes Reports. 18
The incidence of type 1 diabetes (T1D) is rising drastically for the past decades at a rate that cannot be explained by genetic changes alone. Environmental changes are considered to be the main drivers of this change. Recently, the gut microbiota ha
Autor:
Sindhu Mohandas, Andrew L. Goodman, Songyan Deng, Richard Torres, Mark J. Mamula, Jose D. Herazo-Maya, Nalini K. Vudattu, Silvio M. Vieira, James C. Reed, Chris Cotsapas, Elke Gülden, Martin A. Kriegel, Bentley Lim, Kevan C. Herold, Betsy C. Herold, Paula Preston-Hurlburt
Publikováno v:
JCI Insight. 2
The microbiome affects development and activity of the immune system, and may modulate immune therapies, but there is little direct information about this control in vivo. We studied how the microbiome affects regulation of human immune cells in huma
Publikováno v:
Clinical Immunology. 159:143-153
Type 1 Diabetes (T1D) is a multifactorial, immune-mediated disease, which is characterized by the progressive destruction of autologous insulin-producing beta cells in the pancreas. The risk of developing T1D is determined by genetic, epigenetic and
Autor:
Youjia Hu, Xiaojun Zhang, F. Susan Wong, Li Wen, Jian Peng, Fuqiang Liu, Li Chen, Ningwen Tai, Elke Gülden
Publikováno v:
The Journal of Experimental Medicine
Wen et al. show that there are gut microbial antigens sharing significant homology with the host pancreatic protein peptide IGRP and that can drive self-reactive T cell activation and accelerate diabetes in NOD mice.
Both animal model and human
Both animal model and human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadffd9085551220fcb98e78be32b53d
https://orca.cardiff.ac.uk/id/eprint/96317/1/TaiJEM.pdf
https://orca.cardiff.ac.uk/id/eprint/96317/1/TaiJEM.pdf