Výsledky vyhledávání - "Elke Feldmann"

Repair of Sequence-specific 125I-induced Double-strand Breaks by Nonhomologous DNA End Joining in Mammalian Cell-free Extracts

Autor: Petra Pfeiffer, Elke Feldmann, Wolfgang Goedecke, Christian Schunck, Ronald D. Neumann, Andrea Odersky, Igor G. Panyutin, Irina V. Panyutin, Guenter Obe

Publikováno v: Journal of Biological Chemistry. 277:11756-11764

In mammalian cells, nonhomologous DNA end joining (NHEJ) is considered the major pathway of double-strand break (DSB) repair. Rejoining of DSB produced by decay of (125)I positioned against a specific target site in plasmid DNA via a triplex-forming

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34bcaf98ce3b9e19f2ab3c9eb08dc02f
https://doi.org/10.1074/jbc.m111304200

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Accurate in Vitro End Joining of a DNA Double Strand Break with Partially Cohesive 3′-Overhangs and 3′-Phosphoglycolate Termini

Autor: Tong Zhou, Jae-Wan Lee, Petra Pfeiffer, Michele F. Hannah, Shuang Chen, Lawrence F. Povirk, Susan P. Lees-Miller, Elke Feldmann, Kedar V. Inamdar, Yin Yu

Publikováno v: Journal of Biological Chemistry. 276:24323-24330

To examine determinants of fidelity in DNA end joining, a substrate containing a model of a staggered free radical-mediated double-strand break, with cohesive phosphoglycolate-terminated 3'-overhangs and a one-base gap in each strand, was constructed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e908fb0aa273e6f49a6654ac6e53949
https://doi.org/10.1074/jbc.m010544200

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DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining

Autor: Wolfgang Goedecke, Petra Pfeiffer, Susanne Reichenberger, Elke Feldmann, Viola Schmiemann

Publikováno v: Nucleic Acids Research. 28:2585-2596

Non-homologous DNA end joining (NHEJ) is considered the major pathway of double-strand break (DSB) repair in mammalian cells and depends, among other things, on the DNA end-binding Ku70/80 hetero-dimer. To investigate the function of Ku in NHEJ we ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69ed72450cc6be7e6f304d3e2bb7c25
https://doi.org/10.1093/nar/28.13.2585

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A novel nuclease activity from Xenopus laevis releases short oligomers from 5′‐ends of double‐and single‐stranded DNA

Autor: Petra Pfeiffer, Susanne Reichenberger, Elke Feldmann, Bernd Göttlich, Nicole Brüll, Walter Vielmetter

Publikováno v: Genes to Cells. 1:355-367

Background: Double-strand breaks in chromosomal DNA of eucaryotic cells are assumed to be repaired by mechanisms of illegitimate recombination capable of direct rejoining of the broken ends. Cell-free extracts of Xenopus laevis eggs efficiently perfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42157d309ad3a4585b171a5f507b152f
https://doi.org/10.1046/j.1365-2443.1996.d01-245.x

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Mechanisms of Nonhomologous DNA End-Joining in Frogs, Mice and Men

Autor: Bernd Göttlich, Michael Hagmann, Elke Feldmann, Petra Pfeiffer, Susanne Reichenberger, Paula Daza

Publikováno v: Biological Chemistry Hoppe-Seyler. 377:775-786

DNA end-joining, a process related to illegitimate recombination and capable of rejoining unrelated pairs of DNA ends in the absence of sequence homology, is considered the major pathway of double-strand break (DSB) repair in mammalian cells. Whole c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd83902bc80fc0e44a4820566c7122e8
https://doi.org/10.1515/bchm3.1996.377.12.775

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The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV

Autor: Aneta Kuliczkowska, Andrea Odersky, Wolfgang Goedecke, Angelika Eggert, Elke Feldmann, Steffi Kuhfittig-Kulle, Petra Pfeiffer

Publikováno v: Mutagenesis. 22(3)

Non-homologous end joining (NHEJ), the major pathway of double-strand break (DSB) repair in mammalian cells, comprises two subpathways: one that requires the three core factors Ku70/80, DNA-PKcs and XRCC4/LigIV (DNA-PK-dependent NHEJ) and the other t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9f8a01ccd441fc68664c4812e8e357
https://pubmed.ncbi.nlm.nih.gov/17347130

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Analysis of DNA double-strand break repair by nonhomologous end joining in cell-free extracts from mammalian cells

Autor: Petra, Pfeiffer, Elke, Feldmann, Andrea, Odersky, Steffi, Kuhfittig-Kulle, Wolfgang, Goedecke

Publikováno v: Methods in molecular biology (Clifton, N.J.). 291

Double-strand breaks (DSBs) in genomic DNA are induced by ionizing radiation or radiomimetic drugs, but they also occur spontaneously during the cell cycle at quite significant frequencies. In vertebrate cells, nonhomologous DNA end joining (NHEJ) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3e6107a8a9bb081e8eba5d47e345e816
https://pubmed.ncbi.nlm.nih.gov/15502235

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Rejoining of DNA double-strand breaks in vitro by single-strand annealing

Autor: Elke Feldmann, Bernd Göttlich, Susanne Reichenberger, Petra Pfeiffer

Publikováno v: European journal of biochemistry. 258(2)

Nonhomologous DNA end joining (NHEJ) is considered the major pathway of double-strand break (DSB) repair in vertebrate cells. Various studies indicated the existence of at least two different NHEJ pathways; one that joins DNA ends accurately and depe

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https://pubmed.ncbi.nlm.nih.gov/9874203

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