Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Elke Deuerling"'
Autor:
Sandra J. Fries, Theresa S. Braun, Christoph Globisch, Christine Peter, Malte Drescher, Elke Deuerling
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The eukaryotic ribosome-associated complex (RAC) plays a significant role in de novo protein folding. Its unique interaction with the ribosome, comprising contacts to both ribosomal subunits, suggests a RAC-mediated coordination between tran
Externí odkaz:
https://doaj.org/article/abd6bff357c04ad59b98e16224bbcb52
Autor:
Marie A. Hanebuth, Roman Kityk, Sandra J. Fries, Alok Jain, Allison Kriel, Veronique Albanese, Tancred Frickey, Christine Peter, Matthias P. Mayer, Judith Frydman, Elke Deuerling
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The correct folding of proteins often requires the intervention molecular chaperones, which can occur co-translationally. Here the authors identify elements of yeast Ssb (Hsp70) that mediate ribosomal binding, and suggest a mechanism that directs eff
Externí odkaz:
https://doaj.org/article/45bf1ec4fc9046fa86502a2fa61438d3
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143457 (2015)
Both the yeast nascent polypeptide-associated complex (NAC) and the Hsp40/70-based chaperone system RAC-Ssb are systems tethered to the ribosome to assist cotranslational processes such as folding of nascent polypeptides. While loss of NAC does not c
Externí odkaz:
https://doaj.org/article/30be15e9476643bca56f16fdde50c6b8
Publikováno v:
Antibiotics, Vol 5, Iss 2, p 18 (2016)
Many antibiotics target the ribosome and interfere with its translation cycle. Since translation is the source of all cellular proteins including ribosomal proteins, protein synthesis and ribosome assembly are interdependent. As a consequence, the ac
Externí odkaz:
https://doaj.org/article/c58cba4824374c9e9c491e015159831f
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9929 (2010)
The metacaspase Mca1 from Saccharomyces cerevisiae displays a Q/N-rich region at its N-terminus reminiscent of yeast prion proteins. In this study, we show that the ability of Mca1 to form insoluble aggregates is modulated by a peptide stretch preced
Externí odkaz:
https://doaj.org/article/c30e1ae52446493cad9759f3e4dda085
Autor:
Mateusz Jaskolowski, Ahmad Jomaa, Martin Gamerdinger, Sandeep Shrestha, Marc Leibundgut, Elke Deuerling, Nenad Ban
Publikováno v:
Nature Structural & Molecular Biology, 30 (6)
The translocon-associated protein (TRAP) complex resides in the endoplasmic reticulum (ER) membrane and interacts with the Sec translocon and the ribosome to facilitate biogenesis of secretory and membrane proteins. TRAP plays a key role in the secre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead2cfba7dfe8ffd538784e22b26a481
https://doi.org/10.1038/s41594-023-00990-0
https://doi.org/10.1038/s41594-023-00990-0
Autor:
Véronique Albanèse, Roman Kityk, Marie Anne Hanebuth, Matthias P. Mayer, Tancred Frickey, Alok Jain, Elke Deuerling, Sandra J. Fries, Christine Peter, Allison Kriel, Judith Frydman
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications
Hsp70 chaperones assist de novo folding of newly synthesized proteins in all cells. In yeast, the specialized Hsp70 Ssb directly binds to ribosomes. The structural basis and functional mode of recruitment of Ssb to ribosomes is not understood. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d492158a3e7609822ea92189958e17
https://doaj.org/article/45bf1ec4fc9046fa86502a2fa61438d3
https://doaj.org/article/45bf1ec4fc9046fa86502a2fa61438d3
Autor:
Elke Deuerling, Sheena E. Radford, Nadine Sachs, Patrick D. Knight, Judith Frydman, Renate Schlömer, Lukas Leiendecker, Martin Gamerdinger, Karina Gense, Antonio N. Calabrese, Koning Shen, Ankit Baghel, Rebecca Chan, Esther M. Martin, Katie L. Stewart
Publikováno v:
Molecular Cell
Summary The nascent polypeptide-associated complex (NAC) is a conserved ribosome-associated protein biogenesis factor. Whether NAC exerts chaperone activity and whether this function is restricted to de novo protein synthesis is unknown. Here, we dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eafe34f7c85aa9564c71c1510ee9fea
https://eprints.whiterose.ac.uk/143506/8/1-s2.0-S1097276519301868-main.pdf
https://eprints.whiterose.ac.uk/143506/8/1-s2.0-S1097276519301868-main.pdf
Autor:
Carolin Sailer, Ahmad Jomaa, Nenad Ban, Annalena Wallisch, Martin Gamerdinger, Nadine Sachs, Renate Schlömer, Kan Kobayashi, Florian Stengel, Elke Deuerling, Stefan G. Kreft
Publikováno v:
Molecular Cell, 75 (5)
Cotranslational processing of newly synthesized proteins is fundamental for correct protein maturation. Protein biogenesis factors are thought to bind nascent polypeptides not before they exit the ribosomal tunnel. Here, we identify a nascent chain r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891db80296eadebabeead77c38dbe6a0
Autor:
Rainer Nikolay, Thorsten Mielke, Sabine Schmidt, Matthias Selbach, David Schwefel, Justus Loerke, Jörg Bürger, Carlos H. Vieira-Vieira, Bo Qin, Timo Flügel, Elke Deuerling, Christian M. T. Spahn, T. Hilal, Takuya Ueda, Kazuaki Amikura
Publikováno v:
Molecular Cell. 81:1200-1215.e9
Ribosome biogenesis is a fundamental multi-step cellular process that culminates in the formation of ribosomal subunits, whose production and modification are regulated by numerous biogenesis factors. In this study, we analyze physiologic prokaryotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc3fd4fe6c526dc4b5b522d7fa7afea
https://doi.org/10.1016/j.molcel.2021.02.006
https://doi.org/10.1016/j.molcel.2021.02.006