Early gene expression analysis in 9L orthotopic tumor-bearing rats identifies immune modulation in molecular response to synchrotron microbeam radiation therapy.

Autor: Audrey Bouchet, Nathalie Sakakini, Michèle El Atifi, Céline Le Clec'h, Elke Brauer, Anaïck Moisan, Pierre Deman, Pascal Rihet, Géraldine Le Duc, Laurent Pelletier

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e81874 (2013)

Synchrotron Microbeam Radiation Therapy (MRT) relies on the spatial fractionation of the synchrotron photon beam into parallel micro-beams applying several hundred of grays in their paths. Several works have reported the therapeutic interest of the r

Externí odkaz: https://doaj.org/article/aea6fdd2a1d74c62859085a3bd49d073

Synchrotron X-ray microtransections: a non invasive approach for epileptic seizures arising from eloquent cortical areas

Autor: Karin Pernet-Gallay, Olivier David, Elke Brauer, Philippe Kahane, Antoine Depaulis, Raphaël Serduc, Christian Nemoz, François Estève, Marine Potez, Luc Renaud, Jean A. Laissue, Benoît Pouyatos, Tanguy Chabrol

Publikováno v: Pouyatos, B; Nemoz, C; Chabrol, T; Potez, Marine Therese Charlette; Bräuer, E; Renaud, L; Pernet-Gallay, K; Estève, F; David, O; Kahane, P; Laissue, Jean; Depaulis, A; Serduc, R (2016). Synchrotron X-ray microtransections: a non invasive approach for epileptic seizures arising from eloquent cortical areas. Scientific Reports, 6(27250), p. 27250. Nature Publishing Group 10.1038/srep27250
Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, 6, pp.27250-27250. ⟨10.1038/srep27250⟩
Scientific Reports, 2016, 6, pp.27250-27250. ⟨10.1038/srep27250⟩
'Scientific Reports ', vol: 6, pages: 27250-1-27250-7 (2016)

International audience; Synchrotron-generated X-ray (SRX) microbeams deposit high radiation doses to submillimetric targets whilst minimizing irradiation of neighboring healthy tissue. We developed a new radiosurgical method which demonstrably transe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2dcfb11c08cc9ce3e098887080058b9
https://boris.unibe.ch/92119/1/srep27250.pdf

Chalcone JAI-51 improves efficacy of synchrotron microbeam radiation therapy of brain tumors

Autor: E.A. Siegbahn, Audrey Bouchet, Jean A. Laissue, Jean Boutonnat, Ahcène Boumendjel, Elke Brauer, Enam A. Khalil, Raphaël Serduc

Publikováno v: Journal of Synchrotron Radiation
Journal of Synchrotron Radiation, 2012, 19 (Pt 4), pp.478-82. ⟨10.1107/S0909049512015105⟩
Journal of Synchrotron Radiation, International Union of Crystallography, 2012, 19 (Pt 4), pp.478-82. ⟨10.1107/S0909049512015105⟩

International audience; Microbeam radiation therapy (MRT), a preclinical form of radiosurgery, uses spatially fractionated micrometre-wide synchrotron-generated X-ray beams. As MRT alone is predominantly palliative for animal tumors, the effects of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd0c017adfa2f5a4bbdfeca89fff252
https://pubmed.ncbi.nlm.nih.gov/22713877

Weanling piglet cerebellum: a surrogate for tolerance to MRT (microbeam radiation therapy) in pediatric neuro-oncology

Autor: T. Bley, Regina Stettler, R. Fatzer, Henry M. Smilowitz, Stephan Birrer, R. Guzman, Alberto Bravin, André Jaggy, Daniel N. Slatkin, Christian Nemoz, Michel Renier, Werner Zimmermann, N. Lyubimova, Wagner Hp, Elke Brauer, Jiri Stepanek, Géraldine Le Duc, Patrick R Kircher, Hans Blattmann, William Thomlinson, Jean A. Laissue, Marco Di Michiel

Publikováno v: SPIE Proceedings.

The cerebellum of the weanling piglet (Yorkshire) was used as a surrogate for the radiosensitive human infant cerebellum in a Swiss-led program of experimental microbeam radiation therapy (MRT) at the ESRF. Five weanlings in a 47 day old litter of se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::015d689eb47ad04d9c9a087b6ae520e6
https://doi.org/10.1117/12.450774

Microbeam Irradiation as a Simultaneously Integrated Boost in a Conventional Whole-Brain Radiotherapy Protocol

Autor: Felix Jaekel, Elke Bräuer-Krisch, Stefan Bartzsch, Jean Laissue, Hans Blattmann, Marten Scholz, Julia Soloviova, Guido Hildebrandt, Elisabeth Schültke

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 15, p 8319 (2022)

Microbeam radiotherapy (MRT), an experimental high-dose rate concept with spatial fractionation at the micrometre range, has shown a high therapeutic potential as well as good preservation of normal tissue function in pre-clinical studies. We investi

Externí odkaz: https://doaj.org/article/4129c2daec4442a4b89b96de8ef82964