Lineage tracing identifies heterogeneous hepatoblast contribution to cell lineages and postembryonic organ growth dynamics.

Autor: Iris A Unterweger, Julie Klepstad, Edouard Hannezo, Pia R Lundegaard, Ala Trusina, Elke A Ober

Publikováno v: PLoS Biology, Vol 21, Iss 10, p e3002315 (2023)

To meet the physiological demands of the body, organs need to establish a functional tissue architecture and adequate size as the embryo develops to adulthood. In the liver, uni- and bipotent progenitor differentiation into hepatocytes and biliary ep

Externí odkaz: https://doaj.org/article/f3dfa61ca94e4f20962d72c9cdc2a81c

Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis.

Autor: Yeliz Boglev, Andrew P Badrock, Andrew J Trotter, Qian Du, Elsbeth J Richardson, Adam C Parslow, Sebastian J Markmiller, Nathan E Hall, Tanya A de Jong-Curtain, Annie Y Ng, Heather Verkade, Elke A Ober, Holly A Field, Donghun Shin, Chong H Shin, Katherine M Hannan, Ross D Hannan, Richard B Pearson, Seok-Hyung Kim, Kevin C Ess, Graham J Lieschke, Didier Y R Stainier, Joan K Heath

Publikováno v: PLoS Genetics, Vol 9, Iss 2, p e1003279 (2013)

Ribosome biogenesis underpins cell growth and division. Disruptions in ribosome biogenesis and translation initiation are deleterious to development and underlie a spectrum of diseases known collectively as ribosomopathies. Here, we describe a novel

Externí odkaz: https://doaj.org/article/f2b587b2488b4beba385b93b524c7da4

Author response: ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma

Autor: Kimberly J Morgan, Karen Doggett, Fansuo Geng, Stephen Mieruszynski, Lachlan Whitehead, Kelly A Smith, Benjamin M Hogan, Cas Simons, Gregory J Baillie, Ramyar Molania, Anthony T Papenfuss, Thomas E Hall, Elke A Ober, Didier YR Stainier, Zhiyuan Gong, Joan K Heath

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8d726efe8c4dce834f4f87b8c0b905c
https://doi.org/10.7554/elife.73407.sa2

A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation

Autor: Jordi Cayuso, Letizia Satriano, Elke A. Ober, David G. Wilkinson, Sara Caviglia, Ronja L.S. Heyne, Jesper B. Andersen, Racha Ahmad, Wolfgang Hofmeister, M Ilcim Thestrup

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Thestrup, M I, Caviglia, S, Cayuso, J, Heyne, R L S, Ahmad, R, Hofmeister, W, Satriano, L, Wilkinson, D G, Andersen, J B & Ober, E A 2019, ' A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation ', Nature Communications, vol. 10, 5220 . https://doi.org/10.1038/s41467-019-13149-7
Thestrup, M I, Caviglia, S, Cayuso, J, Heyne, R L S, Ahmad, R, Hofmeister, W, Satriano, L, Wilkinson, D G, Andersen, J B & Ober, E A 2019, ' A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation ', Nature Communications, vol. 10, no. 1, 5220 . https://doi.org/10.1038/s41467-019-13149-7
Nature Communications

The hepatopancreatic ductal (HPD) system connects the intrahepatic and intrapancreatic ducts to the intestine and ensures the afferent transport of the bile and pancreatic enzymes. Yet the molecular and cellular mechanisms controlling their different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754622edcd1bcea4c39799efbbccccd9
http://link.springer.com/article/10.1038/s41467-019-13149-7

Apex Resection in Zebrafish (Danio rerio) as A Model of Heart Regeneration: A Video-Assisted Guide

Autor: Ibrahim Mohamad Slaiman, Kristian Skriver Andersen, Ditte Gry Ellman, Wolfgang Hofmeister, Elke Annette Ober, Sabrina Bech Mathiesen, Ditte Caroline Andersen

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 5865, p 5865 (2021)
Ellman, D G, Slaiman, I M, Mathiesen, S B, Andersen, K S, Hofmeister, W, Ober, E A & Andersen, D C 2021, ' Apex Resection in Zebrafish (Danio rerio) as a Model of Heart Regeneration: A Video-Assisted Guide ', International Journal of Molecular Sciences (Online), vol. 22, 5865 . https://doi.org/10.3390/ijms22115865
Ellman, D G, Slaiman, I M, Mathiesen, S B, Andersen, K S, Hofmeister, W, Ober, E A & Andersen, D C 2021, ' Apex resection in zebrafish (Danio rerio) as a model of heart regeneration : A video-assisted guide ', International Journal of Molecular Sciences, vol. 22, no. 11, 5865 . https://doi.org/10.3390/ijms22115865

Ischemic heart disease is one of the leading causes of deaths worldwide. A major hindrance to resolving this challenge lies in the mammalian hearts inability to regenerate after injury. In contrast, zebrafish retain a regenerative capacity of the hea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93c887359ac438c626fca59f6b11c97