Lineage tracing identifies heterogeneous hepatoblast contribution to cell lineages and postembryonic organ growth dynamics.

Autor: Iris A Unterweger, Julie Klepstad, Edouard Hannezo, Pia R Lundegaard, Ala Trusina, Elke A Ober

Publikováno v: PLoS Biology, Vol 21, Iss 10, p e3002315 (2023)

To meet the physiological demands of the body, organs need to establish a functional tissue architecture and adequate size as the embryo develops to adulthood. In the liver, uni- and bipotent progenitor differentiation into hepatocytes and biliary ep

Externí odkaz: https://doaj.org/article/f3dfa61ca94e4f20962d72c9cdc2a81c

ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma

Autor: Kimberly J Morgan, Karen Doggett, Fansuo Geng, Stephen Mieruszynski, Lachlan Whitehead, Kelly A Smith, Benjamin M Hogan, Cas Simons, Gregory J Baillie, Ramyar Molania, Anthony T Papenfuss, Thomas E Hall, Elke A Ober, Didier YR Stainier, Zhiyuan Gong, Joan K Heath

Publikováno v: eLife, Vol 12 (2023)

The nucleoporin (NUP) ELYS, encoded by AHCTF1, is a large multifunctional protein with essential roles in nuclear pore assembly and mitosis. Using both larval and adult zebrafish models of hepatocellular carcinoma (HCC), in which the expression of an

Externí odkaz: https://doaj.org/article/00504a5ab43345eda6eb322958fe33b8

LiverZap: A chemoptogenetic tool for global and locally restricted hepatocyte ablation to study cellular behaviours in liver regeneration

Autor: Elizabeth M. G. Ambrosio, Charlotte S. L. Bailey, Iris A. Unterweger, Jens B. Christensen, Marcel P. Bruchez, Pia R. Lundegaard, Elke A. Ober

The liver restores its mass and architecture after injury. Yet, investigating morphogenetic cell behaviours and signals that repair tissue architecture at high spatiotemporal resolution remains challenging. We developed LiverZap, a tuneable chemoptog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06ac4bfece0b83efd8e0ca3d06408ee4
https://doi.org/10.1101/2023.03.13.531762

Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish

Autor: Katarzyna Koltowska, Anne Karine Lagendijk, Cathy Pichol-Thievend, Johanna C. Fischer, Mathias Francois, Elke A. Ober, Alpha S. Yap, Benjamin M. Hogan

Publikováno v: Cell Reports, Vol 13, Iss 9, Pp 1828-1841 (2015)

Lymphatic vessels arise chiefly from preexisting embryonic veins. Genetic regulators of lymphatic fate are known, but how dynamic cellular changes contribute during the acquisition of lymphatic identity is not understood. We report the visualization

Externí odkaz: https://doaj.org/article/0b38814fe9a54367aa6967152f15edac

A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation

Autor: Jordi Cayuso, Letizia Satriano, Elke A. Ober, David G. Wilkinson, Sara Caviglia, Ronja L.S. Heyne, Jesper B. Andersen, Racha Ahmad, Wolfgang Hofmeister, M Ilcim Thestrup

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Thestrup, M I, Caviglia, S, Cayuso, J, Heyne, R L S, Ahmad, R, Hofmeister, W, Satriano, L, Wilkinson, D G, Andersen, J B & Ober, E A 2019, ' A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation ', Nature Communications, vol. 10, 5220 . https://doi.org/10.1038/s41467-019-13149-7
Thestrup, M I, Caviglia, S, Cayuso, J, Heyne, R L S, Ahmad, R, Hofmeister, W, Satriano, L, Wilkinson, D G, Andersen, J B & Ober, E A 2019, ' A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation ', Nature Communications, vol. 10, no. 1, 5220 . https://doi.org/10.1038/s41467-019-13149-7
Nature Communications

The hepatopancreatic ductal (HPD) system connects the intrahepatic and intrapancreatic ducts to the intestine and ensures the afferent transport of the bile and pancreatic enzymes. Yet the molecular and cellular mechanisms controlling their different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754622edcd1bcea4c39799efbbccccd9
http://link.springer.com/article/10.1038/s41467-019-13149-7