Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference

Autor: Daniel Heinzer, Merve Avar, Daniel Patrick Pease, Ashutosh Dhingra, Jiang-An Yin, Elke Schaper, Berre Doğançay, Marc Emmenegger, Anna Spinelli, Kevin Maggi, Andra Chincisan, Simon Mead, Simone Hornemann, Peter Heutink, Adriano Aguzzi

Publikováno v: PLoS Pathogens, Vol 17, Iss 10 (2021)

The cellular prion protein PrPC is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of PrPC may represent therapeutic targets against hu

Externí odkaz: https://doaj.org/article/0bb9cfda63ef41b79c0071537284dc38

Genome-wide identification of microRNAs regulating the human prion protein

Autor: Valeria Eckhardt, Claudia Scheckel, Marc Emmenegger, Daniel Patrick Pease, Ioannis Xenarios, Elke Schaper, Adriano Aguzzi

Publikováno v: Brain Pathology. 29:232-244

The cellular prion protein (PrPC ) is best known for its misfolded disease-causing conformer, PrPS c . Because the availability of PrPC is often limiting for prion propagation, understanding its regulation may point to possible therapeutic targets. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3608b7862a35f1c0ba079a40e4dec135
https://doi.org/10.1111/bpa.12679

Genome-wide identification of microRNAs regulating the human prion protein

Autor: Daniel, Pease, Claudia, Scheckel, Elke, Schaper, Valeria, Eckhardt, Marc, Emmenegger, Ioannis, Xenarios, Adriano, Aguzzi

Publikováno v: Brain Pathol

The cellular prion protein (PrP(C)) is best known for its misfolded disease‐causing conformer, PrP(Sc). Because the availability of PrP(C) is often limiting for prion propagation, understanding its regulation may point to possible therapeutic targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8687e9644e2b393ec850b45acb05e7e7
https://pubmed.ncbi.nlm.nih.gov/30451334

Deep Conservation of Human Protein Tandem Repeats within the Eukaryotes

Autor: Elke Schaper, Maria Anisimova, Olivier Gascuel

Publikováno v: Molecular Biology and Evolution
Molecular Biology and Evolution, Oxford University Press (OUP), 2014, 31 (5), pp.1132-1148. ⟨10.1093/molbev/msu062⟩
Molecular Biology and Evolution, 31 (5)
Molecular Biology and Evolution, 2014, 31 (5), pp.1132-1148. ⟨10.1093/molbev/msu062⟩

Tandem repeats (TRs) are a major element of protein sequences in all domains of life. They are particularly abundant in mammals, where by conservative estimates one in three proteins contain a TR. High generation-scale duplication and deletion rates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81b057609e3430498b69f1b5b514273
https://doi.org/10.1093/molbev/msu062

Iatrogenic and sporadic Creutzfeldt-Jakob disease in 2 sisters without mutation in the prion protein gene

Autor: Dieter R. Zimmermann, Gregor Herfs, Herbert Budka, Adriano Aguzzi, Lukas Jann, Elke Schaper, Rita Moos, Karl Frontzek

Publikováno v: Prion. 9(6)

Human genetic prion diseases have invariably been linked to alterations of the prion protein (PrP) gene PRNP. Two sisters died from probable Creutzfeldt-Jakob disease (CJD) in Switzerland within 14 y. At autopsy, both patients had typical spongiform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccac00b668ddf5a3738cbaf2dcbb8c1e
https://pubmed.ncbi.nlm.nih.gov/26634863