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Akademický článek

Exploring the MIR143-UPAR Axis for the Inhibition of Human Prostate Cancer Cells In Vitro and In Vivo

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 272-283 (2019)

MIR143 is pathologically downregulated and may function as a tumor suppressor in prostate cancer. Likewise, the urokinase plasminogen activator receptor (UPAR) is overexpressed in prostate carcinoma, representing a negative prognostic marker and puta

Externí odkaz: https://doaj.org/article/d8d765c582e04b049197e5a16a0b421e

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Supplementary Table 3 from Comparative microRNA Profiling of Prostate Carcinomas with Increasing Tumor Stage by Deep Sequencing

Autor: Bernd Wullich, Friedrich A. Grässer, Arndt Hartmann, Tilman T. Rau, Helge Taubert, Jaroslaw Szczyrba, Sven Wach, Elke Nolte, Martin Hart

PDF file - 85K, Results of Illumina sequencing of small RNAs with corresponding relative expression of miRNAs. The miRNA expression in five RNA pools of normal, normal prostate, pT2, pT3 and lymph node metastasizing (pN1) PCa was analyzed by deep seq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117f0df15fefb60c0daa0b304f015c75
https://doi.org/10.1158/1541-7786.22510014.v1

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Supplementary Table 1 from Comparative microRNA Profiling of Prostate Carcinomas with Increasing Tumor Stage by Deep Sequencing

Autor: Bernd Wullich, Friedrich A. Grässer, Arndt Hartmann, Tilman T. Rau, Helge Taubert, Jaroslaw Szczyrba, Sven Wach, Elke Nolte, Martin Hart

PDF file - 26K, Clinicopathological characteristics of prostate carcinoma samples used for Illumina sequencing and qRT-PCR validation of the sequencing. The clinicopathological characteristics of the patient set used for deep sequencing are given in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eac78ab962977997859dd873e88854b
https://doi.org/10.1158/1541-7786.22510020

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Supplementary Figure 5 from Comparative microRNA Profiling of Prostate Carcinomas with Increasing Tumor Stage by Deep Sequencing

Autor: Bernd Wullich, Friedrich A. Grässer, Arndt Hartmann, Tilman T. Rau, Helge Taubert, Jaroslaw Szczyrba, Sven Wach, Elke Nolte, Martin Hart

PDF file - 96K, Control experiments carried out in parallel. The individual control experiments shown in Figure 5A and 5B were carried out in parallel to show that the changes in growth behavior were not due to different cell culture conditions. We c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ef0011934c06ccccabc905d005c87e
https://doi.org/10.1158/1541-7786.22510023.v1

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Supplementary Figure 3 from Comparative microRNA Profiling of Prostate Carcinomas with Increasing Tumor Stage by Deep Sequencing

Autor: Bernd Wullich, Friedrich A. Grässer, Arndt Hartmann, Tilman T. Rau, Helge Taubert, Jaroslaw Szczyrba, Sven Wach, Elke Nolte, Martin Hart

PDF file - 123K, Analysis of miR-15a and miR-200b expression by Northern blotting (A) Ectopic expression of miR-15a and miR-200b. 293T cells were transfected either with pSG5 vector or with the pSG5-miR-15a or-200b expression plasmids. The ectopic ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7107c83b236bab3350a1640f32de96b0
https://doi.org/10.1158/1541-7786.22510029

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Supplementary Figure 1 from Comparative microRNA Profiling of Prostate Carcinomas with Increasing Tumor Stage by Deep Sequencing

Autor: Bernd Wullich, Friedrich A. Grässer, Arndt Hartmann, Tilman T. Rau, Helge Taubert, Jaroslaw Szczyrba, Sven Wach, Elke Nolte, Martin Hart

PDF file - 205K, Validation of the microRNA expression profile by Northern blotting. For confirmation of the results obtained by the sequencing the relative expression levels of miR-375, -148a, -200b, -20a, -15a, -145, -143 and let-7c in the RNA pool

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90438c8936736873478580219ebdec8d
https://doi.org/10.1158/1541-7786.22510035.v1

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Supplementary Figure 4 from Comparative microRNA Profiling of Prostate Carcinomas with Increasing Tumor Stage by Deep Sequencing

Autor: Bernd Wullich, Friedrich A. Grässer, Arndt Hartmann, Tilman T. Rau, Helge Taubert, Jaroslaw Szczyrba, Sven Wach, Elke Nolte, Martin Hart

PDF file - 175K, The relative expression of SEC23A, PHLPP1 and PHLPP2 determined by qRT-PCR. (A-C) The relative expression of SEC23A, PHLPP1, and PHLPP2 mRNA was analyzed by qRT-PCR in a patient set of 40 pairs of normal and corresponding pT2 (N0), p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b587f61c49d150b19881226bd912f5cc
https://doi.org/10.1158/1541-7786.22510026.v1

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Supplementary Figure 2 from Comparative microRNA Profiling of Prostate Carcinomas with Increasing Tumor Stage by Deep Sequencing

Autor: Bernd Wullich, Friedrich A. Grässer, Arndt Hartmann, Tilman T. Rau, Helge Taubert, Jaroslaw Szczyrba, Sven Wach, Elke Nolte, Martin Hart

PDF file - 175K, qRT-PCR analysis of miRNAs found deregulated by sequencing. 40 paired samples of prostate carcinoma and the corresponding non-tumor tissues were analyzed by qRT-PCR. In the overall comparison, the changes in miR-20a, -143, -145, -148

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00160e418cf4949ebc68dafd7e4adf9f
https://doi.org/10.1158/1541-7786.22510032.v1

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