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Akademický článek

Expansion of circulating stem-like CD8+ T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice

Autor: Kateryna Onyshchenko, Ren Luo, Elena Guffart, Simone Gaedicke, Anca-Ligia Grosu, Elke Firat, Gabriele Niedermann

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract Combination of radiation therapy (RT) with immune checkpoint blockade can enhance systemic anti-tumor T cell responses. Here, using two mouse tumor models, we demonstrate that adding long-acting CD122-directed IL-2 complexes (IL-2c) to RT/an

Externí odkaz: https://doaj.org/article/f9e6a4f9f7cc441cbb1bcc250a712ba3

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Akademický článek

Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer

Autor: Eleni Gkika, Elke Firat, Sonja Adebahr, Erika Graf, Ilinca Popp, Gianluca Radicioni, Simon S. Lo, Ursula Nestle, Nils H. Nicolay, Gabriele Niedermann, Dan G. Duda, Anca-L. Grosu

Publikováno v: npj Precision Oncology, Vol 7, Iss 1, Pp 1-6 (2023)

Abstract We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8+ cytotoxic T lymphocytes at first follow-up (the primar

Externí odkaz: https://doaj.org/article/537504b77a584db7a48979724411a17a

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Akademický článek

Adding liposomal doxorubicin enhances the abscopal effect induced by radiation/αPD1 therapy depending on tumor cell mitochondrial DNA and cGAS/STING

Autor: Simone Gaedicke, Elke Firat, Gabriele Niedermann, Liqun Wang, Ren Luo, Kateryna Onyshchenko, Xi Rao, Meidan Wang, Beatrice Menz, Anca-Ligia Grosu

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)

Background Localized radiotherapy (RT) can cause a T cell-mediated abscopal effect on non-irradiated tumor lesions, especially in combination with immune checkpoint blockade. However, this effect is still clinically rare and improvements are highly d

Externí odkaz: https://doaj.org/article/133823e568944a20bf45d927283be209

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Akademický článek

Combination treatment with hypofractionated radiotherapy plus IL-2/anti-IL-2 complexes and its theranostic evaluation

Autor: Hua Jing, Michael Hettich, Simone Gaedicke, Elke Firat, Mark Bartholomä, Gabriele Niedermann

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-16 (2019)

Abstract Background Immunogenic radiotherapy (RT) can act synergistically with immune checkpoint blockers (ICBs). However, alternatives are needed for non-responding patients and those with pre-existing or ICB-induced autoimmune symptoms. Combination

Externí odkaz: https://doaj.org/article/e457fde1ed04482cb15845f9bd6b08c0

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