Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response

Autor: Stephanus T. Malherbe, Ray Y. Chen, Patrick Dupont, Ilse Kant, Magdalena Kriel, André G. Loxton, Bronwyn Smith, Caroline G. G. Beltran, Susan van Zyl, Shirely McAnda, Charmaine Abrahams, Elizna Maasdorp, Alex Doruyter, Laura E. Via, Clifton E. Barry, David Alland, Stephanie Griffith- Richards, Annare Ellman, Thomas Peppard, John Belisle, Gerard Tromp, Katharina Ronacher, James M. Warwick, Jill Winter, Gerhard Walzl

Publikováno v: EJNMMI Research, Vol 10, Iss 1, Pp 1-15 (2020)

Abstract Background There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and persisting metabolic act

Externí odkaz: https://doaj.org/article/5d6e9e74073f4ab0a71f8f008e07ff38

The Peripheral Blood Transcriptome Is Correlated With PET Measures of Lung Inflammation During Successful Tuberculosis Treatment

Autor: Trust Odia, Stephanus T. Malherbe, Stuart Meier, Elizna Maasdorp, Léanie Kleynhans, Nelita du Plessis, Andre G. Loxton, Daniel E. Zak, Ethan Thompson, Fergal J. Duffy, Helena Kuivaniemi, Katharina Ronacher, Jill Winter, Gerhard Walzl, Gerard Tromp, the Catalysis TB-Biomarker Consortium, André G. Loxton, Annare Ellman, Bronwyn Smith, Caroline G. G. Beltran, Clifton E. Barry, David Alland, Friedrich Thienemann, James M. Warwick, Kim Stanley, Ilse Kant, Lani Thiart, Lance A. Lucas, Laura E. Via, Lori E. Dodd, Magdalena Kriel, Nelita Plessis Du, Patrick Dupont, Ray Y. Chen, Robert J. Wilkinson, Shubhada Shenai, Stephanie Griffith-Richards

Publikováno v: Frontiers in Immunology, Vol 11 (2021)

Pulmonary tuberculosis (PTB) is characterized by lung granulomas, inflammation and tissue destruction. Here we used within-subject peripheral blood gene expression over time to correlate with the within-subject lung metabolic activity, as measured by

Externí odkaz: https://doaj.org/article/70919f9b260c42568cd12c831dc3bbde

The Functional Response of B Cells to Antigenic Stimulation: A Preliminary Report of Latent Tuberculosis.

Autor: Willem J du Plessis, Léanie Kleynhans, Nelita du Plessis, Kim Stanley, Stephanus T Malherbe, Elizna Maasdorp, Katharina Ronacher, Novel N Chegou, Gerhard Walzl, Andre G Loxton

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0152710 (2016)

Mycobacterium tuberculosis (M.tb) remains a successful pathogen, causing tuberculosis disease numbers to constantly increase. Although great progress has been made in delineating the disease, the host-pathogen interaction is incompletely described. B

Externí odkaz: https://doaj.org/article/bb3f865476bf4f689afebb5da0923231

Transition from Restrictive to Obstructive Lung Function Impairment During Treatment and Follow-Up of Active Tuberculosis

Autor: Grace J Kim, Jonathan G. Goldin, Brian Allwood, Richard N. van Zyl-Smit, Rodney Dawson, Eric D. Bateman, Christopher B. Cooper, Elizna Maasdorp

Publikováno v: International Journal of Chronic Obstructive Pulmonary Disease. 15:1039-1047

CITATION: Allwood, B. W., et al. Transition from restrictive to obstructive lung function impairment during treatment and follow-up of active tuberculosis. International Journal of Chronic Obstructive Pulmonary Disease, 2020(15):039-1047, doi:10.2147

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7d3af892cec169e81cde2cfccca86e0
https://doi.org/10.2147/copd.s219731

Biomarker-guided tuberculosis preventive therapy (CORTIS): a randomised controlled trial

Autor: Thomas J Scriba, Andrew Fiore-Gartland, Adam Penn-Nicholson, Humphrey Mulenga, Stanley Kimbung Mbandi, Bhavesh Borate, Simon C Mendelsohn, Katie Hadley, Chris Hikuam, Masooda Kaskar, Munyaradzi Musvosvi, Nicole Bilek, Steven Self, Tom Sumner, Richard G White, Mzwandile Erasmus, Lungisa Jaxa, Rodney Raphela, Craig Innes, William Brumskine, Andriëtte Hiemstra, Stephanus T Malherbe, Razia Hassan-Moosa, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Mark Hatherill, Kesenogile Baepanye, Tshepiso Baepanye, Ken Clarke, Marelize Collignon, Audrey Dlamini, Candice Eyre, Tebogo Feni, Moogo Fikizolo, Phinda Galane, Thelma Goliath, Alia Gangat, Shirley Malefo-Grootboom, Elba Janse van Rensburg, Bonita Janse van Rensburg, Sophy Kekana, Marietjie Zietsman, Adrianne Kock, Israel Kunene, Aneessa Lakhi, Nondumiso Langa, Hilda Ledwaba, Marillyn Luphoko, Immaculate Mabasa, Dorah Mabe, Nkosinathi Mabuza, Molly Majola, Mantai Makhetha, Mpho Makoanyane, Blossom Makhubalo, Vernon Malay, Juanita Market, Selvy Matshego, Nontsikelelo Mbipa, Tsiamo Mmotsa, Sylvester Modipa, Samuel Mopati, Palesa Moswegu, Primrose Mothaga, Dorothy Muller, Grace Nchwe, Maryna Nel, Lindiwe Nhlangulela, Bantubonke Ntamo, Lawerence Ntoahae, Tedrius Ntshauba, Nomsa Sanyaka, Letlhogonolo Seabela, Pearl Selepe, Melissa Senne, MG Serake, Maria Thlapi, Vincent Tshikovhi, Lebogang Tswaile, Amanda van Aswegen, Lungile Mbata, Constance Takavamanya, Pedro Pinho, John Mdlulu, Marthinette Taljaard, Naydene Slabbert, Sharfuddin Sayed, Tanya Nielson, Ni Ni Sein, Dhineshree Govender, Tilagavathy Chinappa, Mbali Ignatia Zulu, Nonhle Bridgette Maphanga, Senzo Ralph Hlathi, Goodness Khanyisile Gumede, Thandiwe Yvonne Shezi, Jabulisiwe Lethabo Maphanga, Zandile Patrica Jali, Thobelani Cwele, Nonhlanhla Zanele Elsie Gwamanda, Celaphiwe Dlamini, Zibuyile Phindile Penlee Sing, Ntombozuko Gloria Ntanjana, Sphelele Simo Nzimande, Siyabonga Mbatha, Bhavna Maharaj, Atika Moosa, Cara-Mia Corris, Fazlin Kafaar, Hennie Geldenhuys, Angelique Kany Kany Luabeya, Justin Shenje, Natasja Botes, Susan Rossouw, Hadn Africa, Bongani Diamond, Samentra Braaf, Sonia Stryers, Alida Carstens, Ruwiyda Jansen, Simbarashe Mabwe, Roxane Herling, Ashley Veldsman, Lebohgang Makhete, Marcia Steyn, Sivuyile Buhlungu, Margareth Erasmus, Ilse Davids, Patiswa Plaatjie, Alessandro Companie, Frances Ratangee, Helen Veldtsman, Christel Petersen, Charmaine Abrahams, Miriam Moses, Xoliswa Kelepu, Yolande Gregg, Liticia Swanepoel, Nomsitho Magawu, Nompumelelo Cetywayo, Lauren Mactavie, Habibullah Valley, Elizabeth Filander, Nambitha Nqakala, Elizna Maasdorp, Justine Khoury, Belinda Kriel, Bronwyn Smith, Liesel Muller, Susanne Tonsing, Andre Loxton, Andriette Hiemstra, Petri Ahlers, Marika Flinn, Eva Chung, Michelle Chung, Alicia Sato

Publikováno v: The Lancet. Infectious Diseases

Summary Background Targeted preventive therapy for individuals at highest risk of incident tuberculosis might impact the epidemic by interrupting transmission. We tested performance of a transcriptomic signature of tuberculosis (RISK11) and efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7177dcad10cc3ff04cc42dbb59a97559
https://pubmed.ncbi.nlm.nih.gov/33508223