Analgesic effects of Phα1β toxin: a review of mechanisms of action involving pain pathways

Autor: Juliana Figueira da Silva, Nancy Scardua Binda, Elizete Maria Rita Pereira, Mário Sérgio Lima de Lavor, Luciene Bruno Vieira, Alessandra Hubner de Souza, Flávia Karine Rigo, Hèlia Tenza Ferrer, Célio José de Castro Júnior, Juliano Ferreira, Marcus Vinicius Gomez

Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 27 (2021)

Abstract Phα1β is a neurotoxin purified from spider venom that acts as a high-voltage-activated (HVA) calcium channel blocker. This spider peptide has shown a high selectivity for N-type HVA calcium channels (NVACC) and an analgesic effect in sever

Externí odkaz: https://doaj.org/article/4b6cda67962f48fe83439210ab822751

PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina

Autor: Nancy Scardua Binda, Charles Porto Petruceli Carayon, Rafael Mourão Agostini, Ana Cristina do Nascimento Pinheiro, Marta Nascimento Cordeiro, Marco Aurélio Romano Silva, Juliana Figueira Silva, Elizete Maria Rita Pereira, Claudio Antonio da Silva Junior, Célio José de Castro Junior, Andre Luiz Sena Guimarães, Marcus Vinicius Gomez

Publikováno v: Toxins, Vol 8, Iss 3, p 70 (2016)

The in vivo neuroprotective effect of PhTx3-4, a spider toxin N-P/Q calcium channel blocker, was studied in a rat model of NMDA-induced injury of the retina. NMDA (N-Methyl-d-Aspartate)-induced retinal injury in rats reduced the b-wave amplitude by 6

Externí odkaz: https://doaj.org/article/5e419d0628f64ddb8aa10a3e2507e105

The inhibitory effect of Phα1β toxin on diabetic neuropathic pain involves the CXCR4 chemokine receptor

Autor: Célio José de Castro Junior, Cláudio Antônio da Silva Júnior, Juliana Figueira da Silva, Nancy Scardua Binda, Juliano Ferreira, Marcus Vinicius Gomez, Danuza Montijo Diniz, Flavia Viana Santa Cecilia, Marta N. Cordeiro, Elizete Maria Rita Pereira

Publikováno v: Pharmacological Reports. 72:47-54

Diabetic neuropathy is a common cause of painful diabetic neuropathy (PDN). C-X-C chemokine receptor type 4 (CXCR4) expression is increased in peripheral nerve samples from diabetes patients, suggesting a role for CXCR4 in PDN. Therefore, we evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdda0c2ef5c55ef2fa6bd9e3c556a0e1
https://doi.org/10.1007/s43440-019-00002-3

Analgesic and side effects of intravenous recombinant Phα1β

Autor: Ricardo Andrez Machado de Ávila, Gabriela Trevisan, Elizete Maria Rita Pereira, Marco Aurélio Romano Silva, Duana Carvalho dos Santos, Vanessa Araujo Borges, Marcus Vinicius Gomez, Flávia Karine Rigo, Mateus Rossato, Juliano Ferreira, Juliana Figueira da Silva, Danuza Montijo Diniz, Célio J. Castro, Thiago M. Cunha

Publikováno v: The Journal of Venomous Animals and Toxins Including Tropical Diseases
Journal of Venomous Animals and Toxins including Tropical Diseases v.26 2020
The Journal of venomous animals and toxins including tropical diseases
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 26 (2020)
Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 26, Article number: e20190070, Published: 17 APR 2020

Background: Intrathecal injection of voltage-sensitive calcium channel blocker peptide toxins exerts analgesic effect in several animal models of pain. Upon intrathecal administration, recombinant Phα1β exerts the same analgesic effects as the thos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869a1f177548fa5b257ad69dc3e27e51
https://pubmed.ncbi.nlm.nih.gov/32362927

Analgesic effects of the CTK 01512-2 toxin in different models of orofacial pain in rats

Autor: Cláudio Antônio da Silva Júnior, Elizete Maria Rita Pereira, Emanuelle Sistherenn Caminski, Flavia Tasmim Techera Antunes, Alessandra Hubner de Souza, Leandro Mendes de Freitas, Marcus Vinicius Gomez, Eliane Dallegrave

Publikováno v: Pharmacological reports : PR. 72(3)

Orofacial pain is clinically challenging, having therapeutic failures and side effects. This study evaluated the antinociceptive activities of the CTK 01512-2 toxin, the TRPA1 channel antagonist, and the selective inhibitor of the N-type voltage-gate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac4f448acc546b7dd0a33e34be8fcbf
https://pubmed.ncbi.nlm.nih.gov/32399819