Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elizaveta S. Leshchiner"'
Autor:
Yilong Zou, Michael J. Palte, Amy A. Deik, Haoxin Li, John K. Eaton, Wenyu Wang, Yuen-Yi Tseng, Rebecca Deasy, Maria Kost-Alimova, Vlado Dančík, Elizaveta S. Leshchiner, Vasanthi S. Viswanathan, Sabina Signoretti, Toni K. Choueiri, Jesse S. Boehm, Bridget K. Wagner, John G. Doench, Clary B. Clish, Paul A. Clemons, Stuart L. Schreiber
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Clear-cell carcinomas are aggressive tumours characterised by high accumulation of lipids and glycogen. Here, the authors report that these cancers have a common vulnerability to GPX4 inhibition-induced ferroptosis and using CRISPR screen and lipodom
Externí odkaz:
https://doaj.org/article/30381869b6f34533b2be4a86cf0a583a
Autor:
Wenyu Wang, Vasanthi S. Viswanathan, Sabina Signoretti, Clary B. Clish, Michael J. Palte, Jesse S. Boehm, Elizaveta S. Leshchiner, John G. Doench, Bridget K. Wagner, Vlado Dančík, Amy Deik, Toni K. Choueiri, John K. Eaton, Haoxin Li, Yilong Zou, Maria Kost-Alimova, Stuart L. Schreiber, Yuen-Yi Tseng, Rebecca Deasy, Paul A. Clemons
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Clear-cell carcinomas (CCCs) are a histological group of highly aggressive malignancies commonly originating in the kidney and ovary. CCCs are distinguished by aberrant lipid and glycogen accumulation and are refractory to a broad range of anti-cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85efd57e75b18b5bfc28125bd187590
https://doaj.org/article/30381869b6f34533b2be4a86cf0a583a
https://doaj.org/article/30381869b6f34533b2be4a86cf0a583a
Autor:
John K. Eaton, Yilong Zou, Paul A. Clemons, Michael J. Palte, Yuen-Yi Tseng, Rebecca Deasy, Maria Alimova, Wenyu Wang, Elizaveta S. Leshchiner, Jesse S. Boehm, John G. Doench, Stuart L. Schreiber, Bridget K. Wagner, Clary B. Clish, Vasanthi S. Viswanathan, Toni K. Choueiri, Amy Deik, Haoxin Li, Vlado Dančík, Sabina Signoretti
SUMMARYKidney cancers are characterized by extensive metabolic reprogramming and resistance to a broad range of anti-cancer therapies. By interrogating the Cancer Therapeutics Response Portal compound sensitivity dataset, we show that cells of clear-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9902b5fb32fea1727dd43a0f8ed052c
Autor:
Benjamin Chittick, Daniel B. Graham, José Carlos Rodríguez Pérez, Stuart L. Schreiber, Elizaveta S. Leshchiner, Virendar K. Kaushik, Zhifang Cao, Andrew J. Phillips, Michael A. Durney, Ramnik J. Xavier, Huixian Wu, Joshua A. Bittker, Jason S. Rush, Vlado Dančík, Mark J. Daly, Adam Petrone, Alykhan F. Shamji
Advances in human genetics have dramatically expanded our understanding of complex heritable diseases. Genome-wide association studies have identified an allelic series of CARD9 variants associated with increased risk of or protection from inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3de701edf206bec5b7e8f5faa106a3
https://europepmc.org/articles/PMC5664502/
https://europepmc.org/articles/PMC5664502/
Autor:
Silvia Escudero, Andrey A. Parkhitko, Norbert Perrimon, Loren D. Walensky, Marina Godes, James Luccarelli, Elizaveta S. Leshchiner, Gregory H. Bird, Kwadwo Opoku-Nsiah, Joseph A. Bellairs
Publikováno v:
OpenAIRE
Europe PubMed Central
Europe PubMed Central
Activating mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) underlie the pathogenesis and chemoresistance of ∼ 30% of all human tumors, yet the development of high-affinity inhibitors that target the broad range of KRAS mutants re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131bd8b375f46eeb55ea4d514bf7b354
https://europepmc.org/articles/PMC4330742/
https://europepmc.org/articles/PMC4330742/
Autor:
Cisca Wijmenga, Terry K. Means, Robert J. Heath, Agnes Gardet, Zhifang Cao, Aylwin Ng, Mark J. Daly, Elizaveta S. Leshchiner, Jason S. Rush, Hailiang Huang, Alykhan F. Shamji, Natalia B. Nedelsky, John D. Rioux, Mihai G. Netea, Kara L. Conway, Ramnik J. Xavier, Shih-Chin Cheng, Zaida G. Ramirez-Ortiz
Publikováno v:
Immunity, 43, 715-26
Immunity, 43(4), 715-726. CELL PRESS
Immunity, 43, 4, pp. 715-26
Immunity, 43(4), 715-726. CELL PRESS
Immunity, 43, 4, pp. 715-26
Contains fulltext : 152899.pdf (Publisher’s version ) (Closed access) CARD9 is a central component of anti-fungal innate immune signaling via C-type lectin receptors, and several immune-related disorders are associated with CARD9 alterations. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d18a393a6394b02cd9c752b83793ef5
http://hdl.handle.net/2066/152899
http://hdl.handle.net/2066/152899
Autor:
Jordan J. Green, Eugene Chiu, Daniel G. Anderson, Robert Langer, Elizaveta S. Leshchiner, Julie Shi
Publikováno v:
Bioconjugate Chemistry. 17:1162-1169
Endothelial cells are an important cell type to both cardiovascular disease and cancer, as they play critical roles in vascular function and angiogenesis. However, effective and safe gene delivery to primary endothelial cells in the presence of serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad20c2cc702eaf9d5a128b6e7e69e6b
https://doi.org/10.1021/bc0600968
https://doi.org/10.1021/bc0600968
Autor:
Simona Nedelcu, Loren D. Walensky, Jacqueline A. Lees, Alessandra Ianari, Keren I. Hilgendorf, Elizaveta S. Leshchiner, Mindy Maynard, Eliezer Calo
Publikováno v:
Genesdevelopment. 27(9)
The retinoblastoma protein gene RB-1 is mutated in one-third of human tumors. Its protein product, pRB (retinoblastoma protein), functions as a transcriptional coregulator in many fundamental cellular processes. Here, we report a nonnuclear role for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f86ad9d63440a916471c36390b19164d
https://pubmed.ncbi.nlm.nih.gov/23651852
https://pubmed.ncbi.nlm.nih.gov/23651852
Publikováno v:
Proceedings of the National Academy of Sciences. 110
Proapoptotic B-cell lymphoma 2 (BCL-2) antagonist/killer (BAK) and BCL-2–associated X (BAX) form toxic mitochondrial pores in response to cellular stress. Whereas BAX resides predominantly in the cytosol, BAK is constitutively localized to the oute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1425e0839eb3449c1019351b745a098c
https://doi.org/10.1073/pnas.1214313110
https://doi.org/10.1073/pnas.1214313110
Autor:
Evripidis Gavathiotis, Elizaveta S. Leshchiner, Loren D. Walensky, Denis E. Reyna, Joseph A. Bellairs
BCL-2 family proteins are key regulators of the apoptotic pathway. Antiapoptotic members sequester the BCL-2 homology 3 (BH3) death domains of proapoptotic members such as BAX to maintain cell survival. The antiapoptotic BH3-binding groove has been s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c299526c86e747c82fc8a39a8dfabe1
https://europepmc.org/articles/PMC3617124/
https://europepmc.org/articles/PMC3617124/