Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Elizaveta S. Gromova"'
Autor:
Alexander V. Sergeev, Andrei G. Loiko, Adelya I. Genatullina, Alexander S. Petrov, Elena A. Kubareva, Nina G. Dolinnaya, Elizaveta S. Gromova
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 45 (2023)
The methylation of cytosines at CpG sites in DNA, carried out de novo by DNA methyltransferase Dnmt3a, is a basic epigenetic modification involved in gene regulation and genome stability. Aberrant CpG methylation in gene promoters leads to oncogenesi
Externí odkaz:
https://doaj.org/article/d0f8d4fe09894ec6bf4ced09adabb6f7
Impact of G-Quadruplex Structures on Methylation of Model Substrates by DNA Methyltransferase Dnmt3a
Autor:
Andrei G. Loiko, Alexander V. Sergeev, Adelya I. Genatullina, Mayya V. Monakhova, Elena A. Kubareva, Nina G. Dolinnaya, Elizaveta S. Gromova
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10226 (2022)
In mammals, de novo methylation of cytosines in DNA CpG sites is performed by DNA methyltransferase Dnmt3a. Changes in the methylation status of CpG islands are critical for gene regulation and for the progression of some cancers. Recently, the poten
Externí odkaz:
https://doaj.org/article/87c1cb17538547ab8ab49d40424593c1
Autor:
Anzhela V. Pavlova, Mayya V. Monakhova, Anna M. Ogloblina, Natalia A. Andreeva, Gennady Yu. Laptev, Vladimir I. Polshakov, Elizaveta S. Gromova, Maria I. Zvereva, Marianna G. Yakubovskaya, Tatiana S. Oretskaya, Elena A. Kubareva, Nina G. Dolinnaya
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8773 (2020)
DNA mismatch repair (MMR) plays a crucial role in the maintenance of genomic stability. The main MMR protein, MutS, was recently shown to recognize the G-quadruplex (G4) DNA structures, which, along with regulatory functions, have a negative impact o
Externí odkaz:
https://doaj.org/article/0fc4c203ba9641169340eb92738c5065
Autor:
Svetlana V Kostyuk, Margarita A Kvasha, Daria A Khrabrova, Olga V Kirsanova, Elizaveta S Ershova, Elena M Malinovskaya, Natalia N Veiko, Alexander A Ivanov, Vasiliy S Koval, Alexei L Zhuze, Vadim H Tashlitsky, Pavel E Umriukhin, Sergey I Kutsev, Elizaveta S Gromova
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0189826 (2018)
Hypermethylation is observed in the promoter regions of suppressor genes in the tumor cancer cells. Reactivation of these genes by demethylation of their promoters is a prospective strategy of the anticancer therapy. Previous experiments have shown t
Externí odkaz:
https://doaj.org/article/05f28bd824684e1c93a67533e6846ab0
Publikováno v:
Biochemistry. Biokhimiia. 86(3)
In mammals, DNA methylation is an essential epigenetic modification necessary for the maintenance of genome stability, regulation of gene expression, and other processes. Carcinogenesis is accompanied by multiple changes in the DNA methylation patter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2240c610c1a8a3d457f44aafe85450
https://pubmed.ncbi.nlm.nih.gov/33838631
https://pubmed.ncbi.nlm.nih.gov/33838631
Autor:
Natalia A. Andreeva, M. V. Monakhova, Marianna G. Yakubovskaya, Elena A. Kubareva, Maria I. Zvereva, Gennady Yu. Laptev, Nina G. Dolinnaya, Anna M. Ogloblina, Tatiana S. Oretskaya, Vladimir I. Polshakov, Elizaveta S. Gromova, Anzhela V. Pavlova
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8773, p 8773 (2020)
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8773, p 8773 (2020)
DNA mismatch repair (MMR) plays a crucial role in the maintenance of genomic stability. The main MMR protein, MutS, was recently shown to recognize the G-quadruplex (G4) DNA structures, which, along with regulatory functions, have a negative impact o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5f1c967dcd2c2dd1121e777c6b1c77
Publikováno v:
Молекулярная биология. :318-325
DNA methylation at cytosine residues in CpG sites by DNA methyltransferases (MTases) is associated with various cell processes. Eukaryotic MTase Dnmt3a is the key enzyme that establishes the de novo methylation pattern. A new in vitro assay for DNA m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d062a05ebef8df935db620d9da4cb81a
https://doi.org/10.7868/s0026898418020167
https://doi.org/10.7868/s0026898418020167
Autor:
Andrei G. Loiko, Elizaveta S. Gromova, Daria A. Khrabrova, Maria I. Zvereva, Natalia A. Cherepanova, Anastasia A. Tolkacheva, O. V. Kirsanova
Publikováno v:
Biomolecules
Volume 10
Issue 1
Volume 10
Issue 1
In mammals, DNA methylation is necessary for the maintenance of genomic stability, gene expression regulation, and other processes. During malignant diseases progression, changes in both DNA methylation patterns and DNA methyltransferase (MTase) gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc94964eacd5b3dde83a30bab0721c7
https://pubmed.ncbi.nlm.nih.gov/31861499
https://pubmed.ncbi.nlm.nih.gov/31861499
Publikováno v:
Biochemistry. Biokhimiia. 84(1)
Olivomycin A is a highly active antitumor drug that belongs to the family of aureolic acid antibiotics. The antitumor effect of olivomycin A is related to its ability to bind to the DNA minor groove in GC-rich regions as Mg2+-coordinated complexes. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c414cd668d046f0054ce9e5c5dcf9e
https://pubmed.ncbi.nlm.nih.gov/30927527
https://pubmed.ncbi.nlm.nih.gov/30927527
Autor:
Olga Yu. Susova, Vladimir Oleinikov, O. V. Kirsanova, Vasiliy S. Koval, Natalya A. Shalginskikh, Alexei L. Zhuze, Elizaveta S. Gromova, Alexander A. Ivanov, Victor I. Salyanov, Margarita A. Kvasha, A. A. Stomakhin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2634-2638
A series of new fluorescent symmetric dimeric bisbenzimidazoles DBP(n) bearing bisbenzimidazole fragments joined by oligomethylene linkers with a central 1,4-piperazine residue were synthesized. The complex formation of DBP(n) in the DNA minor groove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf7373199541eb58332bbc1839b7e40
https://doi.org/10.1016/j.bmcl.2015.04.087
https://doi.org/10.1016/j.bmcl.2015.04.087