Chronic SIV-Induced neuroinflammation disrupts CCR7+ CD4+ T cell immunosurveillance in the rhesus macaque brain.

Autor: Elizaldi SR; Graduate Group in Immunology, UCD, Davis, California, USA., Hawes CE; Graduate Group in Immunology, UCD, Davis, California, USA., Verma A; Department of Pathology, School of Medicine, University of Pittsburgh, Pennsylvania, USA., Shaan Lakshmanappa Y; California National Primate Research Center, UCD, Davis, California, USA., Dinasarapu AR; Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia, USA., Schlegel BT; Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Rajasundaram D; Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Li J; Bioinformatics Core, UCD, Davis, California, USA., Durbin-Johnson BP; Bioinformatics Core, UCD, Davis, California, USA., Ma ZM; California National Primate Research Center, UCD, Davis, California, USA., Pal PB; Department of Pathology, School of Medicine, University of Pittsburgh, Pennsylvania, USA., Beckman D; California National Primate Research Center, UCD, Davis, California, USA., Ott S; California National Primate Research Center, UCD, Davis, California, USA., Raeman R; Department of Pathology, School of Medicine, University of Pittsburgh, Pennsylvania, USA., Lifson J; AIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, Maryland, USA., Morrison JH; California National Primate Research Center, UCD, Davis, California, USA.; Department of Neurology, School of Medicine, and., Iyer SS; Department of Pathology, School of Medicine, University of Pittsburgh, Pennsylvania, USA.; California National Primate Research Center, UCD, Davis, California, USA.; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, UCD, Davis, California, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Mar 12; Vol. 134 (9). Date of Electronic Publication: 2024 Mar 12.

Deep analysis of CD4 T cells in the rhesus CNS during SIV infection.

Autor: Elizaldi SR; Graduate Group in Immunology, UC Davis, California, United States of America., Verma A; Department of Pathology, School of Medicine, University of Pittsburgh, Pennsylvania, United States of America., Ma ZM; California National Primate Research Center, UC Davis, California, United States of America., Ott S; California National Primate Research Center, UC Davis, California, United States of America., Rajasundaram D; Department of Pediatrics, School of Medicine, University of Pittsburgh, Pennsylvania, United States of America., Hawes CE; Graduate Group in Immunology, UC Davis, California, United States of America., Lakshmanappa YS; California National Primate Research Center, UC Davis, California, United States of America., Cottrell ML; Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America., Kashuba ADM; Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America., Ambrose Z; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pennsylvania, United States of America., Lifson JD; AIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, Maryland, United States of America., Morrison JH; California National Primate Research Center, UC Davis, California, United States of America.; Department of Neurology, School of Medicine, UC Davis, California, United States of America., Iyer SS; Department of Pathology, School of Medicine, University of Pittsburgh, Pennsylvania, United States of America.; California National Primate Research Center, UC Davis, California, United States of America.; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, UC Davis, California, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2023 Dec 07; Vol. 19 (12), pp. e1011844. Date of Electronic Publication: 2023 Dec 07 (Print Publication: 2023).

CCR7+ CD4 T Cell Immunosurveillance Disrupted in Chronic SIV-Induced Neuroinflammation in Rhesus Brain.

Autor: Elizaldi SR, Hawes CE, Verma A, Dinasarapu AR, Lakshmanappa YS, Schlegel BT, Rajasundaram D, Li J, Durbin-Johnson BP, Ma ZM, Beckman D, Ott S, Lifson J, Morrison JH, Iyer SS

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 31. Date of Electronic Publication: 2023 Aug 31.

Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge 1 year later.

Autor: Milligan EC; Department of Microbiology and Immunology, Children's Research Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Olstad K; California National Primate Research Center, University of California at Davis, Davis, CA 95616, USA., Williams CA; Department of Pediatrics, Weill Cornell Medical College, New York, NY 10065, USA., Mallory M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Cano P; Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Cross KA; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Munt JE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Garrido C; Center for Immunology and Infectious Diseases, University of California at Davis, Davis, CA 95616, USA., Lindesmith L; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Watanabe J; California National Primate Research Center, University of California at Davis, Davis, CA 95616, USA., Usachenko JL; California National Primate Research Center, University of California at Davis, Davis, CA 95616, USA., Hopkins L; California National Primate Research Center, University of California at Davis, Davis, CA 95616, USA., Immareddy R; California National Primate Research Center, University of California at Davis, Davis, CA 95616, USA., Shaan Lakshmanappa Y; Center for Immunology and Infectious Diseases, University of California at Davis, Davis, CA 95616, USA., Elizaldi SR; Center for Immunology and Infectious Diseases, University of California at Davis, Davis, CA 95616, USA.; Graduate Group in Immunology, University of California at Davis, Davis, CA 95616, USA., Roh JW; Center for Immunology and Infectious Diseases, University of California at Davis, Davis, CA 95616, USA.; Graduate Group in Immunology, University of California at Davis, Davis, CA 95616, USA., Sammak RL; California National Primate Research Center, University of California at Davis, Davis, CA 95616, USA., Pollard RE; School of Veterinary Medicine, University of California at Davis, Davis, CA 95616, USA., Yee JL; California National Primate Research Center, University of California at Davis, Davis, CA 95616, USA., Herbek S; Department of Pediatrics, Weill Cornell Medical College, New York, NY 10065, USA., Scobey T; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Miehlke D; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA., Fouda G; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA., Ferrari G; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA., Gao H; Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA., Shen X; Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA., Kozlowski PA; Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA., Montefiori D; Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA., Hudgens MG; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Edwards DK; Moderna Inc., Cambridge, MA 02139, USA., Carfi A; Moderna Inc., Cambridge, MA 02139, USA., Corbett KS; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Graham BS; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA., Fox CB; Access to Advanced Health Institute, Seattle, WA 98102, USA.; Department of Global Health, University of Washington, Seattle, WA 98105, USA., Tomai M; 3M Corporate Research Materials Laboratory, Saint Paul, MN 55144, USA., Iyer SS; California National Primate Research Center, University of California at Davis, Davis, CA 95616, USA.; Center for Immunology and Infectious Diseases, University of California at Davis, Davis, CA 95616, USA., Baric R; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Reader R; California National Primate Research Center, University of California at Davis, Davis, CA 95616, USA., Dittmer DP; Department of Microbiology and Immunology, Children's Research Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Pediatrics, Weill Cornell Medical College, New York, NY 10065, USA., Van Rompay KKA; California National Primate Research Center, University of California at Davis, Davis, CA 95616, USA.; Department of Pathology, Microbiology and Immunology, University of California at Davis, Davis, CA 95616, USA., Permar SR; Department of Pediatrics, Weill Cornell Medical College, New York, NY 10065, USA., De Paris K; Department of Microbiology and Immunology, Children's Research Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Mar; Vol. 15 (685), pp. eadd6383. Date of Electronic Publication: 2023 Mar 01.

Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection.

Autor: Hawes CE; Graduate Group in Immunology, University of California, Davis, CA, 95616, USA.; Center for Immunology and Infectious Diseases, University of California, Davis, CA, 95616, USA., Elizaldi SR; Graduate Group in Immunology, University of California, Davis, CA, 95616, USA.; Center for Immunology and Infectious Diseases, University of California, Davis, CA, 95616, USA., Beckman D; California National Primate Research Center, University of California, Davis, CA, 95616, USA., Diniz GB; California National Primate Research Center, University of California, Davis, CA, 95616, USA., Shaan Lakshmanappa Y; Center for Immunology and Infectious Diseases, University of California, Davis, CA, 95616, USA., Ott S; California National Primate Research Center, University of California, Davis, CA, 95616, USA., Durbin-Johnson BP; Division of Biostatistics, School of Medicine, University of California, Davis, CA, 95616, USA., Dinasarapu AR; Department of Human Genetics, Emory University, Atlanta, GA, USA., Gompers A; Center for Immunology and Infectious Diseases, University of California, Davis, CA, 95616, USA., Morrison JH; California National Primate Research Center, University of California, Davis, CA, 95616, USA. jhmorrison@ucdavis.edu.; Department of Neurology, School of Medicine, University of California, Davis, CA, 95616, USA. jhmorrison@ucdavis.edu., Iyer SS; Center for Immunology and Infectious Diseases, University of California, Davis, CA, 95616, USA. smiyer@ucdavis.edu.; California National Primate Research Center, University of California, Davis, CA, 95616, USA. smiyer@ucdavis.edu.; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA. smiyer@ucdavis.edu.

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2022 Oct 06; Vol. 19 (1), pp. 250. Date of Electronic Publication: 2022 Oct 06.