Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Elizabeth de Wolf"'
Autor:
Elizabeth de Wolf, Marwan Ibrahim Abdullah, Stefanie M. Jones, Karen Menezes, Darren M. Moss, Falko P. Drijfhout, Sarah R. Hart, Clare Hoskins, Euan A. Stronach, Alan Richardson
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Pre-clinical and retrospective studies of patients using statins to reduce plasma cholesterol have suggested that statins may be useful to treat cancer. However, prospective clinical trials have yet to demonstrate significant efficacy. We ha
Externí odkaz:
https://doaj.org/article/ba16009471344089ac5a439986164551
Publikováno v:
Royal Society Open Science, Vol 6, Iss 8 (2019)
The Cx26 mRNA has not been reported to undergo alternative splicing. In expressing a series of human keratitis ichthyosis deafness (KID) syndrome mutations of Cx26 (A88V, N14K and A40V), we found the production of a truncated mRNA product. These muta
Externí odkaz:
https://doaj.org/article/b27d54084ab0434a8c4c711f3c3cebee
Autor:
Daniel Maddison, Sarbjit Nijjar, Louise Meigh, Thomas L. Rodgers, Elizabeth de Wolf, Martin J. Cann, Nicholas Dale
Publikováno v:
Journal of physiology, 2021, Vol.599(1), pp.103-118 [Peer Reviewed Journal]
Key points A moderate increase in P C O 2 (55 mmHg) closes Cx26 gap junctions. This effect of CO2 is independent of changes in intra- or extracellular pH. The CO2 -dependent closing effect depends on the same residues (K125 and R104) that are require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c796fb8136f67f9d7f151bd1da022c97
https://doi.org/10.1113/jp280747
https://doi.org/10.1113/jp280747
Autor:
Sarbjit, Nijjar, Daniel, Maddison, Louise, Meigh, Elizabeth, de Wolf, Thomas, Rodgers, Martin J, Cann, Nicholas, Dale
Publikováno v:
The Journal of physiologyReferences. 599(1)
A moderate increase inCx26 hemichannels open in response to moderate elevations of CO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f62becdc7a3932bd86820aee168a051
https://pubmed.ncbi.nlm.nih.gov/33022747
https://pubmed.ncbi.nlm.nih.gov/33022747
Autor:
Elizabeth de Wolf, Jonathan Cook, Valentin-Mihai Dospinescu, Maria Assunta Biscotti, Fokion Spanos, Marco Gerdol, Nicholas Dale, Sarbjit Nijjar
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-14 (2019)
A subclade of connexins comprising Cx26, Cx30, and Cx32 are directly sensitive to CO2. CO2 binds to a carbamylation motif present in these connexins and causes their hemichannels to open. Cx26 may contribute to CO2-dependent regulation of breathing i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4825d8084fa6ef5d1fb50250664a06e
https://doi.org/10.1038/s42003-019-0576-2
https://doi.org/10.1038/s42003-019-0576-2
Statins are widely used to treat hypercholesterolaemia. However, by inhibiting the production of mevalonate, they also reduce the production of several isoprenoids that are necessary for the function of small GTPase oncogenes such as Ras. As such, st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342117b7ca484f1e139865e4a5f680a6
https://eprints.keele.ac.uk/5032/1/20180619_richardson_1-s2.0-S030573721830104X-main.pdf
https://eprints.keele.ac.uk/5032/1/20180619_richardson_1-s2.0-S030573721830104X-main.pdf
Autor:
Valentin-Mihai, Dospinescu, Sarbjit, Nijjar, Fokion, Spanos, Jonathan, Cook, Elizabeth, de Wolf, Maria Assunta, Biscotti, Marco, Gerdol, Nicholas, Dale
Publikováno v:
Communications Biology
A subclade of connexins comprising Cx26, Cx30, and Cx32 are directly sensitive to CO2. CO2 binds to a carbamylation motif present in these connexins and causes their hemichannels to open. Cx26 may contribute to CO2-dependent regulation of breathing i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ccb81629f2230ef88a028b98b3150065
https://pubmed.ncbi.nlm.nih.gov/31508505
https://pubmed.ncbi.nlm.nih.gov/31508505
Publikováno v:
Oncology Letters.
There is considerable interest in redeploying drugs for use in combination with other oncology therapeutics. The single-agent activity of statins in ovarian cancer has been widely reported, however the drug concentration required to cause cell death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b008a498cdfa6d44b60159b2aaf526
https://doi.org/10.3892/ol.2017.7516
https://doi.org/10.3892/ol.2017.7516
Autor:
Euan A. Stronach, Elizabeth de Wolf, Falko P. Drijfhout, Sarah R. Hart, K. Menezes, Darren M. Moss, Marwan Ibrahim Abdullah, Alan Richardson, Stefanie M. Jones, Clare Hoskins
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Pre-clinical and retrospective studies of patients using statins to reduce plasma cholesterol have suggested that statins may be useful to treat cancer. However, prospective clinical trials have yet to demonstrate significant efficacy. We have previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ba18e6dfc90af16e611378473a0bf9
https://pubmed.ncbi.nlm.nih.gov/28710496
https://pubmed.ncbi.nlm.nih.gov/28710496
Publikováno v:
Proceedings of the Royal Society B: Biological Sciences
CO 2 readily combines with H 2 O to form and H + . Because an increase of only 100 nM in the concentration of H + (a decrease of 0.1 unit of pH) in blood can prove fatal, the regulated excretion of CO 2 during breathing is an essential life-preservin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9fcd4aabcb4aef86d93ee624bc3094a
https://pubmed.ncbi.nlm.nih.gov/28148750
https://pubmed.ncbi.nlm.nih.gov/28148750